{"id":2,"date":"2021-08-17T18:06:45","date_gmt":"2021-08-17T18:06:45","guid":{"rendered":"http:\/\/labs.wsu.edu\/bacteria-host-cell-interactions\/?page_id=2"},"modified":"2023-05-22T09:39:37","modified_gmt":"2023-05-22T16:39:37","slug":"sample-page","status":"publish","type":"page","link":"https:\/\/labs.wsu.edu\/bacteria-host-cell-interactions\/","title":{"rendered":"Dr. Michael Konkel"},"content":{"rendered":"<div class=\"wsu-hero wsu-width--full wsu-pattern--wsu-light-radial-left \">\n\t\n\t<div class=\"wsu-image-frame wsu-image-frame--fill\">\n\t<img decoding=\"async\" src=\"https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/2779\/2021\/08\/campylobacter-jejuni.jpg\"\n\t\tsrcset=\"https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/2779\/2021\/08\/campylobacter-jejuni.jpg 1188w, https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/2779\/2021\/08\/campylobacter-jejuni.jpg 396w, https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/2779\/2021\/08\/campylobacter-jejuni.jpg 792w, https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/2779\/2021\/08\/campylobacter-jejuni.jpg 768w, https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/2779\/2021\/08\/campylobacter-jejuni.jpg 990w\"\n\t\tsizes=\"(max-width: 1188px) 100vw, 1188px\"\n\t\talt=\"Microscopic photography of campylobacter jejuni\"\n\t\tstyle=\"object-position: 50% 50%\"\n\t\t\/>\n<\/div>\n\n\t<div class=\"wsu-overlay wsu-pattern-after wsu-overlay--dark-left wsu-pattern--wsu-light-radial-left\"><\/div>\n\t<div class=\"wsu-hero__content\">\n\t\t<div class=\"wsu-hero__caption\">\n\t\t\t\t\t\t<div class=\"wsu-eyebrow-header\">\n\t\t\t\tBacteria-Host Cell Interactions\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"title-id-69d5e60716c2b\" class=\"wsu-title wsu-hero__title\"><span>Foodborne Illness<\/span><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"wsu-caption wsu-hero__copy\">\n\t\t\t\tCampylobacter jejuni demonstrates specific binding to host epithelial cells\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n\n\n<h1 class=\"wp-block-heading\">Dr. Michael Konkel<\/h1>\n\n\n<div class=\"wsu-row wsu-row--single\" >\r\n    \n<div class=\"wsu-column\"  style=\"\">\r\n\t\n\n<p>C. jejuni are stained red, host cell microfilaments are stained green, and cell nuclei are stained blue.<\/p>\n\n<\/div>\r\n\n<\/div>\n\n<div class=\"wsu-row wsu-row--sidebar-right\" >\r\n    \n<div class=\"wsu-column\"  style=\"\">\r\n\t\n\n<h2 class=\"wp-block-heading\">Research &amp; Interests:<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Improving Human and Animal Health through Understanding of Disease<\/h3>\n\n\n\n<p>Campylobacter species are the most common culture-proven cause of bacterial gastroenteritis worldwide, accounting for 400 \u2013 500 million cases of diarrhea each year. In developed countries, particular strains of C. jejuni correlates with a higher incidence of Guillain-Barr\u00e9 syndrome, reactive arthritis, and\/or post-infectious irritable bowel syndrome. In low- and middle-income countries, C. jejuni infections result in malnourishment and stunted growth (reduced height). Additionally, reports of antibiotic-resistant Campylobacter continue to increase and fluoroquinolone-resistant Campylobacter spp. have been added to the World Health Organization priority list of antibiotic-resistant bacteria. However, studies dissecting the fundamental mechanisms of C. jejuni virulence factors and their contribution to disease in a susceptible host are sparse.<\/p>\n\n\n\n<p>Dr. Mike Konkel is a professor in the School of Molecular Biosciences at Washington State University. The Konkel research group focuses on the characterization of host-C. jejuni interactions. Biochemistry, cell biology, molecular biology, and high throughput genomic\/proteomic approaches are currently being used to understand the unique virulence factors that contribute to the pathogenesis of this facultative intracellular bacterium. One of our current aims is to identify and dissect the mechanism of cell binding and entry-promoting proteins used by C. jejuni to cause disease. To this extent, we have identified several bacterial adhesins and secreted effector proteins. Dr. Konkel\u2019s research is supported by a grant from the NIH.<\/p>\n\n<\/div>\r\n\n\n<div class=\"wsu-column\"  style=\"\">\r\n\t\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" loading=\"lazy\" width=\"396\" height=\"594\" src=\"https:\/\/s3.wp.wsu.edu\/uploads\/sites\/2779\/2021\/08\/konkel-michael-500w750hjpg-396x594.jpg\" alt=\"Dr. Michael Konkel\" class=\"wp-image-46\" srcset=\"https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/2779\/2021\/08\/konkel-michael-500w750hjpg-396x594.jpg 396w, https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/2779\/2021\/08\/konkel-michael-500w750hjpg.jpg 500w\" sizes=\"(max-width: 396px) 100vw, 396px\" \/><\/figure>\n\n\n\n<p><a href=\"https:\/\/vetmed.wsu.edu\/departments\/school-of-molecular-biosciences\/\">School of Molecular Biosciences<\/a><br>Biotechnology\/Life Sciences<br>Room 447<\/p>\n\n\n\n<p>Office: <a href=\"tel:5093355039\" data-type=\"tel\" data-id=\"tel:5093355039\">509-335-5039<\/a><\/p>\n\n\n\n<p>Lab: <a href=\"tel:5093353522\" data-type=\"tel\" data-id=\"tel:5093353522\">509-335-3522<\/a><br>Fax: 509-335-4159<\/p>\n\n<\/div>\r\n\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Dr. Michael Konkel<\/p>\n","protected":false},"author":1351,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":[],"categories":[],"tags":[],"wsuwp_university_location":[],"wsuwp_university_org":[],"_links":{"self":[{"href":"https:\/\/labs.wsu.edu\/bacteria-host-cell-interactions\/wp-json\/wp\/v2\/pages\/2"}],"collection":[{"href":"https:\/\/labs.wsu.edu\/bacteria-host-cell-interactions\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.wsu.edu\/bacteria-host-cell-interactions\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.wsu.edu\/bacteria-host-cell-interactions\/wp-json\/wp\/v2\/users\/1351"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.wsu.edu\/bacteria-host-cell-interactions\/wp-json\/wp\/v2\/comments?post=2"}],"version-history":[{"count":26,"href":"https:\/\/labs.wsu.edu\/bacteria-host-cell-interactions\/wp-json\/wp\/v2\/pages\/2\/revisions"}],"predecessor-version":[{"id":225,"href":"https:\/\/labs.wsu.edu\/bacteria-host-cell-interactions\/wp-json\/wp\/v2\/pages\/2\/revisions\/225"}],"wp:attachment":[{"href":"https:\/\/labs.wsu.edu\/bacteria-host-cell-interactions\/wp-json\/wp\/v2\/media?parent=2"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/labs.wsu.edu\/bacteria-host-cell-interactions\/wp-json\/wp\/v2\/categories?post=2"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/labs.wsu.edu\/bacteria-host-cell-interactions\/wp-json\/wp\/v2\/tags?post=2"},{"taxonomy":"wsuwp_university_location","embeddable":true,"href":"https:\/\/labs.wsu.edu\/bacteria-host-cell-interactions\/wp-json\/wp\/v2\/wsuwp_university_location?post=2"},{"taxonomy":"wsuwp_university_org","embeddable":true,"href":"https:\/\/labs.wsu.edu\/bacteria-host-cell-interactions\/wp-json\/wp\/v2\/wsuwp_university_org?post=2"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}