{"id":2,"date":"2022-10-05T19:43:33","date_gmt":"2022-10-05T19:43:33","guid":{"rendered":"http:\/\/labs.wsu.edu\/duttke\/?page_id=2"},"modified":"2025-12-05T08:46:03","modified_gmt":"2025-12-05T16:46:03","slug":"sample-page","status":"publish","type":"page","link":"https:\/\/labs.wsu.edu\/duttke\/","title":{"rendered":"Home"},"content":{"rendered":"<div class=\"wsu-hero wsu-width--full wsu-pattern--wsu-light-radial-left   wsu-hero--size-small \">\n\t\n\t<div class=\"wsu-image-frame wsu-image-frame--fill\">\n\t<img decoding=\"async\" src=\"https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/3142\/2025\/05\/Image3-scaled.jpg\"\n\t\tsrcset=\"https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/3142\/2025\/05\/Image3-scaled.jpg 2560w, https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/3142\/2025\/05\/Image3-scaled.jpg 396w, https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/3142\/2025\/05\/Image3-scaled.jpg 792w, https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/3142\/2025\/05\/Image3-scaled.jpg 768w, https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/3142\/2025\/05\/Image3-scaled.jpg 1536w, https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/3142\/2025\/05\/Image3-scaled.jpg 2048w, https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/3142\/2025\/05\/Image3-scaled.jpg 198w\"\n\t\tsizes=\"(max-width: 2560px) 100vw, 2560px\"\n\t\talt=\"Dr. Duttke&#039;s lab group.\"\n\t\tstyle=\"object-position: 54% 53%\"\n\t\t\/>\n<\/div>\n\n\t<div class=\"wsu-overlay wsu-pattern-after wsu-overlay--light wsu-pattern--none\"><\/div>\n\t<div class=\"wsu-hero__content\">\n\t\t<div class=\"wsu-hero__caption\">\n\t\t\t\t\t\t\t\t\t<div id=\"title-id-69f31ccc2d875\" class=\"wsu-title wsu-hero__title\"><span>Duttke<br>Lab<\/span><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"wsu-caption wsu-hero__copy\">\n\t\t\t\tDecoding what brings genomes to life\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n\n\n<h1 class=\"wp-block-heading\">Transcription regulation in health and disease<\/h1>\n\n\n<div class=\"wsu-row wsu-row--sidebar-right\" >\r\n    \n<div class=\"wsu-column wsu-color-background--white\"  style=\"\">\r\n\t\n<section  class=\"wsu-section wsu-color-background--gray-5 wsu-callout--color-crimson wsu-spacing-before--none wsu-spacing-after--large\"  >\r\n        \n\n<p><strong>Research Interests<\/strong>: We strive to better understand the molecular mechanisms that regulate the expression of our genome in health and disease to apply such knowledge to the study, prevention, treatment, and prediction of disease outcomes. A major hurdle toward this goal is insufficient knowledge of how and which transcription factors and networks thereof interpret regulatory DNA. To address this need, we exploit genetic diversity, bioinformatics, and nascent transcriptomics. We envision that gained knowledge will enable predicting disease outcomes based on profiling the gene expression state of immune cells, eventually skewing immune gene expression profiles toward more favorable outcomes.<\/p>\n\n    <\/section>\n<\/div>\r\n\n\n<div class=\"wsu-column\"  style=\"\">\r\n\t\n\n<hr class=\"wp-block-separator has-css-opacity\" \/>\n\n\n\n<h2 class=\"wp-block-heading\">Recent News<\/h2>\n\n\n<ul class=\"wsu-news-list\">\r\n\t\t\t<li>\r\n\t\t\t<a href=\"https:\/\/labs.wsu.edu\/duttke\/2025\/11\/05\/bayley-mcdonald-awarded-the-prestigious-poncin-fellowship\/\">Bayley McDonald awarded the prestigious Poncin Fellowship!<\/a> \r\n\t\t\t\t\t\t\t\t\t\t<div class=\"wsu-meta-date\"><time>November 5, 2025<\/time><\/div>\r\n\t\t\t\t\t<\/li>\r\n\t\t\t<li>\r\n\t\t\t<a href=\"https:\/\/labs.wsu.edu\/duttke\/2025\/04\/14\/eva-rickard-awarded-prestigious-goldwater-scholarship\/\">Eva Rickard Awarded Prestigious Goldwater Scholarship<\/a> \r\n\t\t\t\t\t\t\t\t\t\t<div class=\"wsu-meta-date\"><time>April 14, 2025<\/time><\/div>\r\n\t\t\t\t\t<\/li>\r\n\t\t\t<li>\r\n\t\t\t<a href=\"https:\/\/labs.wsu.edu\/duttke\/2025\/03\/24\/undergraduate-research-stars-shine-at-surca-2025\/\">Undergraduate Research Stars Shine at SURCA 2025<\/a> \r\n\t\t\t\t\t\t\t\t\t\t<div class=\"wsu-meta-date\"><time>March 24, 2025<\/time><\/div>\r\n\t\t\t\t\t<\/li>\r\n\t<\/ul>\r\n\n\n<div class=\"wsu-cta \" >\n\t<a \t\t\t\t\thref=\"https:\/\/labs.wsu.edu\/duttke\/lab-news\/\"\t\n\t\tclass=\"wsu-button  wsu-button--style-outline wsu-button--size-small\">\n\t\t\t\n\t\tView all news\t\t\t<\/a>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\" \/>\n\n<\/div>\r\n\n<\/div>\n\n\n<h2 class=\"wp-block-heading\">Research<\/h2>\n\n\n<div class=\"wsu-row wsu-row--thirds\" >\r\n    \n<div class=\"wsu-column\"  style=\"\">\r\n\t\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"720\" height=\"475\" src=\"https:\/\/s3.wp.wsu.edu\/uploads\/sites\/3142\/2023\/04\/gene-regulation-04-23.jpg\" alt=\"Artistic illustration of genetics by https:\/\/pixabay.com\/photos\/dna-3d-biology-genetic-research-5378928\/ on Pixabay.\" class=\"wp-image-159\" srcset=\"https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/3142\/2023\/04\/gene-regulation-04-23.jpg 720w, https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/3142\/2023\/04\/gene-regulation-04-23-396x261.jpg 396w, https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/3142\/2023\/04\/gene-regulation-04-23-198x131.jpg 198w\" sizes=\"(max-width: 720px) 100vw, 720px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Gene regulation in health and disease:<\/h3>\n\n\n\n<p>Interrogating your immune system for prognostics and diagnostics<\/p>\n\n\n\n<p><\/p>\n\n\n<div class=\"wsu-cta \" >\n\t<a aria-label=\"Read more about &quot;Gene regulation in health and disease.&quot;\"\t\t\t\t\thref=\"https:\/\/labs.wsu.edu\/duttke\/research\/\"\t\n\t\tclass=\"wsu-button  wsu-button--style-outline wsu-button--size-small\">\n\t\t\t\n\t\tRead more\t\t\t<\/a>\n<\/div>\n\n\n\n<p><\/p>\n\n<\/div>\r\n\n\n<div class=\"wsu-column\"  style=\"\">\r\n\t\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"720\" height=\"475\" src=\"https:\/\/s3.wp.wsu.edu\/uploads\/sites\/3142\/2023\/04\/spatial-grammar-genome-04-23.jpg\" alt=\"Artist illustration of genetics by https:\/\/pixabay.com\/users\/thedigitalartist-202249\/ on Pixabay.\" class=\"wp-image-155\" srcset=\"https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/3142\/2023\/04\/spatial-grammar-genome-04-23.jpg 720w, https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/3142\/2023\/04\/spatial-grammar-genome-04-23-396x261.jpg 396w, https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/3142\/2023\/04\/spatial-grammar-genome-04-23-198x131.jpg 198w\" sizes=\"(max-width: 720px) 100vw, 720px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">The spatial grammar of our genome:<\/h3>\n\n\n\n<p>Decoding gene regulation from the perspective of the transcription start site<\/p>\n\n\n\n<p><\/p>\n\n\n<div class=\"wsu-cta \" >\n\t<a aria-label=\"Read more about &quot;The spatial grammar of our genome.&quot;\"\t\t\t\t\thref=\"https:\/\/labs.wsu.edu\/duttke\/research\/\"\t\n\t\tclass=\"wsu-button  wsu-button--style-outline wsu-button--size-small\">\n\t\t\t\n\t\tRead more\t\t\t<\/a>\n<\/div>\n\n\n\n<p><\/p>\n\n<\/div>\r\n\n\n<div class=\"wsu-column\"  style=\"\">\r\n\t\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"720\" height=\"475\" src=\"https:\/\/s3.wp.wsu.edu\/uploads\/sites\/3142\/2023\/04\/human-dispersed-04-23.jpg\" alt=\"Artistic illustration from https:\/\/pixabay.com\/users\/sch%C3%A4ferle-3372715\/ on Pixabay.\" class=\"wp-image-151\" srcset=\"https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/3142\/2023\/04\/human-dispersed-04-23.jpg 720w, https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/3142\/2023\/04\/human-dispersed-04-23-396x261.jpg 396w, https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/3142\/2023\/04\/human-dispersed-04-23-198x131.jpg 198w\" sizes=\"(max-width: 720px) 100vw, 720px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Human dispersed transcription initiation:<\/h3>\n\n\n\n<p>Based on their pattern of transcription initiation, regulatory elements such as promoters and enhancers are commonly grouped into \u2018focused\u2019 or \u2018dispersed\u2019.<\/p>\n\n\n\n<p><\/p>\n\n\n<div class=\"wsu-cta \" >\n\t<a aria-label=\"Read more of &quot;Human dispersed transcription initiation.&quot;\"\t\t\t\t\thref=\"https:\/\/labs.wsu.edu\/duttke\/research\/\"\t\n\t\tclass=\"wsu-button  wsu-button--style-outline wsu-button--size-small\">\n\t\t\t\n\t\tRead more\t\t\t<\/a>\n<\/div>\n\n\n\n<p><\/p>\n\n<\/div>\r\n\n<\/div>\n\n<div class=\"wsu-cta \" >\n\t<a aria-label=\"Click here to find out more about joining our team.\"\t\t\t\t\thref=\"https:\/\/labs.wsu.edu\/duttke\/join-us\/\"\t\n\t\tclass=\"wsu-button \">\n\t\t\t\n\t\tJoin us!\t\t\t<\/a>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Transcription regulation in health and disease Research<\/p>\n","protected":false},"author":33745,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":[],"categories":[],"tags":[],"wsuwp_university_location":[],"wsuwp_university_org":[],"_links":{"self":[{"href":"https:\/\/labs.wsu.edu\/duttke\/wp-json\/wp\/v2\/pages\/2"}],"collection":[{"href":"https:\/\/labs.wsu.edu\/duttke\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.wsu.edu\/duttke\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.wsu.edu\/duttke\/wp-json\/wp\/v2\/users\/33745"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.wsu.edu\/duttke\/wp-json\/wp\/v2\/comments?post=2"}],"version-history":[{"count":50,"href":"https:\/\/labs.wsu.edu\/duttke\/wp-json\/wp\/v2\/pages\/2\/revisions"}],"predecessor-version":[{"id":426,"href":"https:\/\/labs.wsu.edu\/duttke\/wp-json\/wp\/v2\/pages\/2\/revisions\/426"}],"wp:attachment":[{"href":"https:\/\/labs.wsu.edu\/duttke\/wp-json\/wp\/v2\/media?parent=2"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/labs.wsu.edu\/duttke\/wp-json\/wp\/v2\/categories?post=2"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/labs.wsu.edu\/duttke\/wp-json\/wp\/v2\/tags?post=2"},{"taxonomy":"wsuwp_university_location","embeddable":true,"href":"https:\/\/labs.wsu.edu\/duttke\/wp-json\/wp\/v2\/wsuwp_university_location?post=2"},{"taxonomy":"wsuwp_university_org","embeddable":true,"href":"https:\/\/labs.wsu.edu\/duttke\/wp-json\/wp\/v2\/wsuwp_university_org?post=2"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}