{"id":128,"date":"2023-11-24T18:08:10","date_gmt":"2023-11-25T02:08:10","guid":{"rendered":"https:\/\/labs.wsu.edu\/jiyue-zhu\/?page_id=128"},"modified":"2025-04-11T12:33:17","modified_gmt":"2025-04-11T19:33:17","slug":"publication","status":"publish","type":"page","link":"https:\/\/labs.wsu.edu\/jiyue-zhu\/publication\/","title":{"rendered":"Publications"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\">Selected Publications<\/h3>\n\n\n\n<ul>\n<li><strong>Modification of the telomerase gene with human regulatory sequences resets mouse telomeres to human length.<\/strong> Zhang, F., Cheng, D., Porter, K.I., Wang, S., Zhang, H., Davis,C.J., and J. Zhu. (2025) <em>Nature Communications<\/em> 16:1211. <em>(doi: 10.1038\/s41467-025-56559-6)<\/em><\/li>\n\n\n\n<li><strong>Telomere dysfunction in Tert knockout mice delays Braf<sup>V600E<\/sup>-induced melanoma development.<\/strong> Zhang, J., Zhang, F., Porter, K.I., Dakup, P., Wang, S., Robertson, G.P., Gaddameedhi, S., and J. Zhu. (2023) <em>Int. J. Cancer (DOI:10.1002\/ijc.34713)<\/em><\/li>\n\n\n\n<li><strong>Polymorphic tandem DNA repeats activate the human telomerase reverse transcriptase gene.<\/strong> Xu, T., Cheng, D., Zhao, Y., Zhang, J., Zhu, X., Zhang, F., Chen, G., Wang, Y., Yan, X., Robertson, G.P., Gaddameedhi, S., Lazarus, P., Wang, S., and J. Zhu. (2021) <em>Proc. Natl. Acad. Sci. USA<\/em>. 118 (26) (<em>doi:10.1073\/pnas.201904311<\/em>)<\/li>\n\n\n\n<li><strong>Crispr\/Cas9-mediated Cleavages Facilitate Homologous Recombination During Genetic Engineering of a Large Chromosomal Region.<\/strong> Zhang, F., Cheng, D., Wang, S., and J. Zhu. (2020) <em>BiotechnolBioeng<\/em>. 117(9):2816-2826 (<em>doi: 10.1002\/bit.27441<\/em>)<\/li>\n\n\n\n<li><strong>ETS variant transcription factor 5 and c-Myc cooperate in derepressing the human telomerase gene promoter via composite ETS\/E-box motifs.<\/strong> Zhang, F., Wang, S., and J. Zhu. (2020) <em>J. Biol. Chem.<\/em> 295(29):10062-10075 (<em>doi:10.1074\/jbc.RA119.012130<\/em>) <\/li>\n\n\n\n<li><strong>Engineering a humanized telomerase reverse transcriptase gene in mouse embryonic stem cells.<\/strong> Cheng, D., Zhao, Y., Zhang, F., Zhang, J., Wang, S., and J. Zhu. (2019) <em>Sci. Rep.<\/em> 9(1):9683 (<em>doi:10.1038\/s41598-019-46160-5<\/em>)<\/li>\n\n\n\n<li><strong>Repression of telomerase gene promoter requires human-specific genomic context and is mediated by multiple HDAC1-containing corepressor complexes<em>.<\/em><\/strong> Cheng, D., Zhao, Y., Wang, S., Zhang, F., Russo, M., McMahon, S.B., and J. Zhu. (2016) <em>FASEB J<\/em>. 31(3):1165-1178. (<em>doi:10.1096\/fj.201601111R<\/em>)<\/li>\n\n\n\n<li><strong>Human Telomerase Reverse Transcriptase (hTERT) Transcription Requires Sp1\/Sp3 Binding to the Promoter and a Permissive Chromatin Environment.<\/strong> Cheng, D., Zhao, Y., Wang, S., Jia, W., Kang, J., and Zhu, J. (2015) <em>J. Biol. Chem. <\/em>290(50):30193-203. (<em>doi:10.1074\/jbc.M115.662221<\/em>)<\/li>\n\n\n\n<li><strong>Dual&nbsp;roles of&nbsp;c-Myc&nbsp;in the regulation of&nbsp;hTERT&nbsp;gene.<\/strong> Zhao, Y., Cheng, D., Wang, S., and J. Zhu. (2014) <em>Nucleic Acids Res<\/em>. 42(16):10385-98<em>. <\/em>(<em>doi:10.1093\/nar\/gku721<\/em>)<\/li>\n\n\n\n<li><strong>A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis.<\/strong> Jia, W., Wang, S., Horner, J. W., Wang, N., Wang, H., Gunther, E. J., DePinho, R. A., and Zhu, J. (2011) <em>FASEB J.<\/em> 25: 979-89.<\/li>\n\n\n\n<li><strong>Distinct and Temporal Roles of Nucleosomal Remodeling and Histone Deacetylation in the Repression of <em>hTERT<\/em> Gene. <\/strong>Wang, S., Hu, C., Zhao, Y., and J. Zhu. (2010) <em>Mol. Biol. Cell<\/em>. 21: 821\u2013832.<\/li>\n\n\n\n<li><strong>Robust activation of the human but not mouse telomerase gene during the induction of pluripotency.<\/strong> Mathew, R., Jia, W., Sharma, A., Zhao, Y., Clarke, L.E., Cheng, X., Wang, H., Salli, U., Vrana, K.E., Robertson, G.P., Zhu, J., and S. Wang. (2010) <em>FASEB J.<\/em> 24:2702-2715.&nbsp;<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Selected Publications<\/p>\n","protected":false},"author":24922,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"categories":[],"tags":[],"wsuwp_university_location":[],"wsuwp_university_org":[],"_links":{"self":[{"href":"https:\/\/labs.wsu.edu\/jiyue-zhu\/wp-json\/wp\/v2\/pages\/128"}],"collection":[{"href":"https:\/\/labs.wsu.edu\/jiyue-zhu\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.wsu.edu\/jiyue-zhu\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.wsu.edu\/jiyue-zhu\/wp-json\/wp\/v2\/users\/24922"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.wsu.edu\/jiyue-zhu\/wp-json\/wp\/v2\/comments?post=128"}],"version-history":[{"count":4,"href":"https:\/\/labs.wsu.edu\/jiyue-zhu\/wp-json\/wp\/v2\/pages\/128\/revisions"}],"predecessor-version":[{"id":159,"href":"https:\/\/labs.wsu.edu\/jiyue-zhu\/wp-json\/wp\/v2\/pages\/128\/revisions\/159"}],"wp:attachment":[{"href":"https:\/\/labs.wsu.edu\/jiyue-zhu\/wp-json\/wp\/v2\/media?parent=128"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/labs.wsu.edu\/jiyue-zhu\/wp-json\/wp\/v2\/categories?post=128"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/labs.wsu.edu\/jiyue-zhu\/wp-json\/wp\/v2\/tags?post=128"},{"taxonomy":"wsuwp_university_location","embeddable":true,"href":"https:\/\/labs.wsu.edu\/jiyue-zhu\/wp-json\/wp\/v2\/wsuwp_university_location?post=128"},{"taxonomy":"wsuwp_university_org","embeddable":true,"href":"https:\/\/labs.wsu.edu\/jiyue-zhu\/wp-json\/wp\/v2\/wsuwp_university_org?post=128"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}