{"id":125,"date":"2022-06-01T14:11:59","date_gmt":"2022-06-01T21:11:59","guid":{"rendered":"https:\/\/labs.wsu.edu\/megaesophagus\/?page_id=125"},"modified":"2026-05-06T13:35:52","modified_gmt":"2026-05-06T20:35:52","slug":"research-publications","status":"publish","type":"page","link":"https:\/\/labs.wsu.edu\/megaesophagus\/research-publications\/","title":{"rendered":"Research publications"},"content":{"rendered":"\n<p id=\"block-d5830f30-62b7-448c-a6f3-77407cdb60bc\">Below is a partial list of recent veterinary publications related to megaesophagus with links to the abstract summary or full publication when available.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">General information and prognosis<\/h2>\n\n\n\n<ul>\n<li>Sinha N, <strong>Haines J<\/strong>, Guess S, Sellon R. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41160986\/\">Owner-perceived assessment of quality-of-life factors for dogs with megaesophagus may help veterinarians better tailor treatment plans. <\/a>J Am Vet Med Assoc. 2025 Oct 29;264(3):1-6. doi: 10.2460\/javma.25.06.0386. <\/li>\n<\/ul>\n\n\n\n<ul>\n<li><strong>Haines JM<\/strong>. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0034528818313389?via%3Dihub\">Survey of owners on population characteristics, diagnosis, and environmental, health, and disease associations in dogs with megaesophagus.<\/a> Res Vet Sci. 2019 Apr;123:1-6. doi: 10.1016\/j.rvsc.2018.11.026. Epub 2018 Nov 30. PMID: 30543946.<\/li>\n<\/ul>\n\n\n\n<ul>\n<li>Nakagawa T, Doi A, Ohno K, Yokoyama N, Tsujimoto H. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6451904\/\">Clinical features and prognosis of canine megaesophagus in Japan.<\/a> J Vet Med Sci. 2019 Mar 14;81(3):348-352. doi: 10.1292\/jvms.18-0493. Epub 2019 Jan 10. PMID: 30626762; PMCID: PMC6451904.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Management of Megaesophagus<\/h2>\n\n\n\n<ul>\n<li>Henderson C, Rossanese M, Salmoral A, Murgia D. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41043475\/\">Surgical management of cricopharyngeal achalasia in Spaniels results in favorable outcomes, with persistence or recurrence of mild signs documented in some dogs.<\/a> J Am Vet Med Assoc. 2025 Oct 3;264(2):1-6. doi: 10.2460\/javma.25.06.0415. PMID: 41043475.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wsu-spacing-before--default\">\n<li>Winston JM 3rd, Mann FAT, Dean L. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36458673\/\">Management and outcomes of 13 dogs treated with a modified Heller myotomy and Dor fundoplication for lower esophageal sphincter achalasia-like syndrome<\/a>. Vet Surg. 2023 Feb;52(2):315-329. doi: 10.1111\/vsu.13912. PMID: 36458673.<\/li>\n\n\n\n<li>Lyngby JG, <strong>Haines JM<\/strong>, Guess SC. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.821\">Use of a videofluoroscopic feeding evaluation to guide management of dogs with congenital idiopathic megaoesophagus.<\/a> Vet Med Sci. 2022 Apr 27. doi: 10.1002\/vms3.821. PMID: 35476311.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wsu-spacing-before--default\">\n<li>Mehain SO, <strong>Haines JM<\/strong>, Guess SC. <a href=\"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/83\/4\/ajvr.21.02.0030.xml\">A randomized crossover study of compounded liquid sildenafil for treatment of generalized megaesophagus in dogs<\/a>. Am J Vet Res. 2022 Jan 21;83(4):317-323. doi: 10.2460\/ajvr.21.02.0030. PMID: 35066488.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wsu-spacing-before--default\">\n<li><strong>Haines JM<\/strong>, Khoo A, Brinkman E, Thomason JM, Mackin AJ. <a href=\"https:\/\/meridian.allenpress.com\/jaaha\/article\/55\/4\/167\/433386\/Technique-for-Evaluation-of-Gravity-Assisted\">Technique for Evaluation of Gravity-Assisted Esophageal Transit Characteristics in Dogs with Megaesophagus.<\/a> J Am Anim Hosp Assoc. 2019 Jul\/Aug;55(4):167-177. doi: 10.5326\/JAAHA-MS-6711. PMID: 31099601.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wsu-spacing-before--default\">\n<li>Quintavalla F, Menozzi A, Pozzoli C, Poli E, Donati P, Wyler DK, Serventi P, Bertini S. <a href=\"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/full\/10.1136\/vr.103832\">Sildenafil improves clinical signs and radiographic features in dogs with congenital idiopathic megaoesophagus: a randomised controlled trial.<\/a> Vet Rec. 2017 Apr 22;180(16):404. doi: 10.1136\/vr.103832. PMID: 28188161.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wsu-spacing-before--default\">\n<li>Manning K, Birkenheuer AJ, Briley J, Montgomery SA, Harris J, Vanone SL, Gookin JL. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvim.14527\">Intermittent At-Home Suctioning of Esophageal Content for Prevention of Recurrent Aspiration Pneumonia in 4 Dogs with Megaesophagus.<\/a> J Vet Intern Med. 2016 Sep;30(5):1715-1719. doi: 10.1111\/jvim.14527. PMID: 27481487<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Genetics and genetic conditions<\/h2>\n\n\n\n<ul class=\"wsu-spacing-before--default\">\n<li>Bell SM, Evans JM, Greif EA, Tsai KL, Friedenberg SG, Clark LA. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37041421\/\">GWAS using low-pass whole genome sequence reveals a novel locus in canine congenital idiopathic megaesophagus.<\/a> Mamm Genome. 2023 Sep;34(3):464-472. doi: 10.1007\/s00335-023-09991-2.  PMID: 37041421<\/li>\n\n\n\n<li>Bell SM, Evans JM, Evans KM, Tsai KL, Noorai RE, Famula TR, Holle DM, Clark LA. <a href=\"https:\/\/journals.plos.org\/plosgenetics\/article?id=10.1371\/journal.pgen.1010044\">Congenital idiopathic megaesophagus in the German shepherd dog is a sex-differentiated trait and is associated with an intronic variable number tandem repeat in Melanin-Concentrating Hormone Receptor 2.<\/a> PLoS Genet. 2022 Mar 10;18(3):e1010044. doi: 10.1371\/journal.pgen.1010044. PMID: 35271580<\/li>\n<\/ul>\n\n\n\n<ul class=\"wsu-spacing-before--default\">\n<li>Farr\u00e9 Marin\u00e9 A, Granger N, Bertolani C, Mascort Boixeda J, Shelton GD, Luj\u00e1n Feliu-Pascual A. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvim.15861\">Long-term outcome of Miniature Schnauzers with genetically confirmed demyelinating polyneuropathy: 12 cases.<\/a> J Vet Intern Med. 2020 Sep;34(5):2005-2011. doi: 10.1111\/jvim.15861. PMID: 32738000<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Underlying causes of Megaesophagus<\/h2>\n\n\n\n<ul>\n<li>Ruiz-Campillo MT, Herrera-Torres G, Molina-Hern\u00e1ndez V, Bautista MJ, Barrero-Torres DM, L\u00f3pez-Rasero J, P\u00e9rez J. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39609897\/\">Megaoesophagus associated to inflammatory infiltrate in the autonomous plexus in a 7-year-old Spanish Water Dog. BMC Vet Res<\/a>. 2024 Nov 29;20(1):534. doi: 10.1186\/s12917-024-04399-9. PMID: 39609897<\/li>\n<\/ul>\n\n\n\n<ul class=\"wsu-spacing-before--default\">\n<li>Azargoun R, Hashemi-Asl SM, Asri-Rezaei S. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38770199\/\">Generalized megaesophagus associated with Schmidt-like syndrome in a dog<\/a>. Vet Res Forum. 2024;15(4):215-218. doi: 10.30466\/vrf.2024.2011964.4014. PMID: 38770199<\/li>\n\n\n\n<li>\u00d8sterg\u00e5rd Jensen S, Christen M, Rondahl V, Holland CT, Jagannathan V, Leeb T, Giger U. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36140701\/\"><em>EHBP1L1<\/em> Frameshift Deletion in English Springer Spaniel Dogs with Dyserythropoietic Anemia and Myopathy Syndrome (DAMS) or Neonatal Losses.<\/a> Genes (Basel). 2022 Aug 26;13(9):1533. doi: 10.3390\/genes13091533. PMID: 36140701<\/li>\n\n\n\n<li>Hurley KJ, Mansfield C, VanHoutan IM, Lacorcia L, Allenspach K, Hebbard G, Marks SL, Poppenga R, Kaufman JH, Weimer BC, Woolard KD, Bielitzki J, Lulham D, Naar J. <a href=\"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/259\/2\/javma.259.2.172.xml\">A comparative analysis of two unrelated outbreaks in Latvia and Australia of acquired idiopathic megaesophagus in dogs fed two brands of commercial dry dog foods: 398 cases (2014-2018).<\/a> J Am Vet Med Assoc. 2021 Jul 15;259(2):172-183. doi: 10.2460\/javma.259.2.172. PMID: 34227867.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wsu-spacing-before--default\">\n<li>Renwick M, Stevenson MA, Wiethoelter A, Mansfield C. <a href=\"https:\/\/bmcvetres.biomedcentral.com\/articles\/10.1186\/s12917-020-02376-6\">A case-control study to identify risk factors for adult-onset idiopathic megaoesophagus in Australian dogs, 2017-2018<\/a>. BMC Vet Res. 2020 May 24;16(1):157. doi: 10.1186\/s12917-020-02376-6. PMID: 32448348; PMCID: PMC7247263.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wsu-spacing-before--default\">\n<li>Gomes SA, Van Ham L, Van Ham A, Ives EJ, Vanhaesebrouck A. <a href=\"https:\/\/meridian.allenpress.com\/jaaha\/article\/56\/1\/7\/433452\/Canine-Nonstructural-Megaesophagus-as-a-Clinical\">Canine Nonstructural Megaesophagus as a Clinical Sign of Potential Neurological Disease: 99 Cases.<\/a> J Am Anim Hosp Assoc. 2020 Jan\/Feb;56(1):7-16. doi: 10.5326\/JAAHA-MS-6955. Epub 2019 Nov 12. PMID: 31715113.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wsu-spacing-before--default\">\n<li>Grobman ME, Schachtel J, Gyawali CP, Lever TE, Reinero CR. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvim.15578\">Videofluoroscopic swallow study features of lower esophageal sphincter achalasia-like syndrome in dogs.<\/a> J Vet Intern Med. 2019 Sep;33(5):1954-1963. doi: 10.1111\/jvim.15578. Epub 2019 Aug 5. PMID: 31381208; PMCID: PMC6766503.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Complications of Megaesophagus<\/h2>\n\n\n\n<ul>\n<li>Kornya M, Kashevska-Gozdek M, Sun Y, Bersenas A. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41716509\/\"><em>Candida glabrata (Nakaseomyces glabratus)<\/em> as a component of aspiration pneumonia in a dog with megaesophagus. <\/a>Can Vet J. 2026 Feb 1;67(2):149-154. PMID: 41716509; <\/li>\n<\/ul>\n\n\n\n<ul>\n<li>Anderson KL, Tefft KM. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40570295\/\">Esophageal Candidiasis in Two Dogs With Megaesophagus: A Case Report<\/a>. J Vet Intern Med. 2025 Jul-Aug;39(4):e70184. doi: 10.1111\/jvim.70184. PMID: 40570295; PMCID: PMC12201271.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Canine megaesophagus research publications.  Below is a partial list of recent veterinary publications related to megaesophagus with links to the abstract summary or full publication when available.<\/p>\n","protected":false},"author":17676,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_wsuwp_accessibility_report":null},"categories":[],"tags":[],"wsuwp_university_location":[],"wsuwp_university_org":[],"_links":{"self":[{"href":"https:\/\/labs.wsu.edu\/megaesophagus\/wp-json\/wp\/v2\/pages\/125"}],"collection":[{"href":"https:\/\/labs.wsu.edu\/megaesophagus\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.wsu.edu\/megaesophagus\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.wsu.edu\/megaesophagus\/wp-json\/wp\/v2\/users\/17676"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.wsu.edu\/megaesophagus\/wp-json\/wp\/v2\/comments?post=125"}],"version-history":[{"count":9,"href":"https:\/\/labs.wsu.edu\/megaesophagus\/wp-json\/wp\/v2\/pages\/125\/revisions"}],"predecessor-version":[{"id":268,"href":"https:\/\/labs.wsu.edu\/megaesophagus\/wp-json\/wp\/v2\/pages\/125\/revisions\/268"}],"wp:attachment":[{"href":"https:\/\/labs.wsu.edu\/megaesophagus\/wp-json\/wp\/v2\/media?parent=125"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/labs.wsu.edu\/megaesophagus\/wp-json\/wp\/v2\/categories?post=125"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/labs.wsu.edu\/megaesophagus\/wp-json\/wp\/v2\/tags?post=125"},{"taxonomy":"wsuwp_university_location","embeddable":true,"href":"https:\/\/labs.wsu.edu\/megaesophagus\/wp-json\/wp\/v2\/wsuwp_university_location?post=125"},{"taxonomy":"wsuwp_university_org","embeddable":true,"href":"https:\/\/labs.wsu.edu\/megaesophagus\/wp-json\/wp\/v2\/wsuwp_university_org?post=125"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}