Curcumin is the principal curcuminoid found in turmeric, a widely consumed natural product used in cooking and traditional medicine. In 2021, turmeric ranked as the second top-selling herbal supplement in the U.S., with nearly $100 million in sales. Curcumin is often used to manage arthritis and other inflammatory conditions, sometimes alongside pharmaceutical drugs.<\/p>\n
Recent laboratory data show that curcumin is a\u00a0potent inhibitor of UGT2B17<\/a><\/strong>, an enzyme involved in drug metabolism.\u00a0UGT2B17<\/a><\/strong> metabolizes diclofenac, a commonly used NSAID for pain and arthritis. Genetic differences in UGT2B17, especially gene deletions<\/a><\/strong>, could lead to poor metabolism of diclofenac, increasing the risk of side effects. Considering both turmeric\/curcumin and diclofenac are used for arthritis and other inflammatory conditions, there is a high likelihood of patients co-consuming curcumin and diclofenac, raising concerns for variable diclofenac pharmacokinetics and toxicity risk.<\/p>\n Our research aims to evaluate how curcumin affects the metabolism of diclofenac, particularly in individuals with genetic variations in UGT2B17. This study will help determine whether co-consumption of curcumin alters diclofenac pharmacokinetics and contributes to variability in drug response.<\/p>\n<\/p><\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":" <\/p>\n Curcumin is the principal curcuminoid found in turmeric, a widely consumed natural product used in cooking and traditional medicine. In 2021, turmeric ranked as the second top-selling herbal supplement in the U.S., with nearly $100 million in sales. Curcumin is often used to manage arthritis and other inflammatory conditions, sometimes alongside pharmaceutical drugs.<\/p>\n Recent laboratory data show that curcumin is a\u00a0potent inhibitor of UGT2B17<\/a><\/strong>, an enzyme involved in drug metabolism.\u00a0UGT2B17<\/a><\/strong> metabolizes diclofenac, a commonly used NSAID for pain and arthritis. Genetic differences in … » More …<\/span><\/a><\/p>\n","protected":false},"author":44184,"featured_media":849,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-builder.php","meta":[],"wsuwp_university_location":[],"wsuwp_university_org":[],"_links":{"self":[{"href":"https:\/\/labs.wsu.edu\/paine\/wp-json\/wp\/v2\/pages\/846"}],"collection":[{"href":"https:\/\/labs.wsu.edu\/paine\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.wsu.edu\/paine\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.wsu.edu\/paine\/wp-json\/wp\/v2\/users\/44184"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.wsu.edu\/paine\/wp-json\/wp\/v2\/comments?post=846"}],"version-history":[{"count":6,"href":"https:\/\/labs.wsu.edu\/paine\/wp-json\/wp\/v2\/pages\/846\/revisions"}],"predecessor-version":[{"id":856,"href":"https:\/\/labs.wsu.edu\/paine\/wp-json\/wp\/v2\/pages\/846\/revisions\/856"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/labs.wsu.edu\/paine\/wp-json\/wp\/v2\/media\/849"}],"wp:attachment":[{"href":"https:\/\/labs.wsu.edu\/paine\/wp-json\/wp\/v2\/media?parent=846"}],"wp:term":[{"taxonomy":"wsuwp_university_location","embeddable":true,"href":"https:\/\/labs.wsu.edu\/paine\/wp-json\/wp\/v2\/wsuwp_university_location?post=846"},{"taxonomy":"wsuwp_university_org","embeddable":true,"href":"https:\/\/labs.wsu.edu\/paine\/wp-json\/wp\/v2\/wsuwp_university_org?post=846"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}What is Curcumin?<\/strong><\/h5>\n
What is the focus of our research?
<\/strong><\/h5>\n