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Md Masud Parvez

Position: Research Associate (Non-tenured faculty rank)

 Education:

Ph.D. in Pharmacology/ Clinical Pharmacology – INJE University, College of Medicine, Busan, South Korea

Master of Pharmacy (major in Pharmacology) – State University of Bangladesh, Dhaka, Bangladesh

Bachelor of Pharmacy (major in Pharmacology) – State University of Bangladesh, Dhaka, Bangladesh

Research Interests:

  • ADME/DMPK in vitro characterization of the drug compound
  • Drug transporters and metabolizing enzymes (DMETs) mediated PK, drug-drug interactions (DDI)
  • Physiologically-based pharmacokinetic (PBPK) modeling to predict clinical PK and understanding underlying mechanisms
  • Pharmacogenomics and its role on interindividual PK variability and clinical PK/PD phenotype
  • Clinical Pharmacokinetics (PK) study (Phase-I, BE, DDI)

About:

Dr. Masud is working as a research associate in the Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University Spokane, WA. Before joining WSU, he has worked as Research Assistant Professor in the Department of Pharmacology in Shin lab, College of Medicine, INJE University, Busan, South Korea and also as a Postdoctoral Fellow in Bendayan lab, Department of Pharmaceutical Sciences, University of Toronto, Toronto, Canada. His current research is focussed on in vitro drug transporters (uptake/ efflux) and metabolism (Phase I, II) study and expression of the major DMETs among special populations like pediatrics and their role on PK and DDI by PBPK modeling and simulations and future translational application to personalized medicine.

Publications:

  1. Md. Hasanuzzaman, Myeongjin Yi, Munju Cho, Md Masud Parvez, Su-Jun Lee and Jae Gook Shin. Increased Expression of P-glycoprotein (P-gp) in THP-1 Cell Derived Macrophages by Rifampin May Reduce Efficacy of the P-gp Substrate Anti-Tuberculosis Drugs. J of Pharm Sci. (2019 Apr 13. pii: S0022-3549(19)30235-7, September 2019.
  2. Nguyen Thi Thu Phuong, Md Masud Parvez and Jae-Gook Shin et al. Physiologically Based Pharmacokinetic Modeling Approach to Predict Drug-Drug Interactions with Ethionamide Involving Impact of Genetic Polymorphism on FMO3. J Clin Pharmacol. 2019 Jun;59(6):880-889
  3. Md Masud Parvez, Nazia Kaisar, Ho-Jung Shin, Jung Ho Lee and Jae-Gook Shin. Comprehensively substrate characterization of 22 anti-tuberculosis drugs for solute carrier (SLC) transporters. Antimicrobial Agents and Chemotherapy. Sep 2018 Volume 62 Issue 9 e00512-18
  4. Nguyen Thi Thu Phuong, Md Masud Parvez, Min Jung Kim, Jung Ho Lee, Jong-Lyul Ghim, Jae-Gook Shin. Development of Physiologically Based Pharmacokinetic Model of Ethionamide in Pediatric Population by Application of Flavin-containing Monooxygenase 3. J Clin Pharmacol. 2018 Oct;58(10):1347-1360
  5. Md Masud Parvez, Nazia Kaisar, and Jae-Gook Shin. Role of Drug Metabolic Enzymes and Transporters in Drug-Drug Interactions between Antiretroviral and Antituberculosis Drugs. Journal of Advance Biotechnology and Therapeutics (Accepted in JUN 2018)
  6. Michelle Raubenheimer, Md Masud Parvez and Jae-Gook Shin. Clinical Implementation of Pharmacogenomics for Personalized Precision Medicine: Barriers and Solutions. Journal of Pharmaceutical Sciences. 2017 Sep;106(9):2368-2379
  7. Md Masud Parvez, Ho-Jung Shin, Jin-Ah Jung and Jae-Gook Shin. Evaluation of paraaminosalicylic acid (PAS) as a substrate of multiple solute carrier (SLC) uptake transporters and possible drug-interactions with NSAIDs. Antimicrobial Agents and Chemotherapy. 2017 Sep; 61(5): e02392-16
  8.  Md Masud Parvez, Nazia Kaisar, Jin-Ah Jung, Ho-Jung Shin, and Jae-Gook Shin. Inhibitory effect of 22 anti-tuberculosis drugs on organic anion and organic cation transporter of SLC22A family. 2016. Antimicrobial Agents and Chemotherapy. 2016 Nov;60 (11): 6558 –6567, September 2019
  9. Md Masud Parvez, Jin-Ah Jung, Ho-Jung Shin, Dong Hyun Kim and Jae-Gook Shin. Characterization of 22 anti-tuberculosis drugs for the inhibitory interaction potential on organic anionic transporter polypeptides (OATPs) mediated uptake. Antimicrobial Agents and Chemotherapy. 2016 Apr 22;60(5):3096-105
  10.  Md. Al Amin Sikder, Mohammad A. Kaisar, Md Masud Parvez, A. K. M. Nawshad Hossian, Farzana Akhter, and Mohammad A. Rashid, 2011. Preliminary Antimicrobial Activity and Cytotoxicity of Leaf Extracts of Mesua nagassarium (Burm.f.). Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants. Vol. 10 (1), P. 83-87.
  11. Md. Al Amin Sikder, Md Masud Parvez, A.K. M. Nawshad Hossian, and Mohammad A. Rashid, 2011. Membrane stabilizing activity – a possible mechanism of action for the anti-inflammatory activity of two Bangladeshi medicinal plants: Mesua nagassarium (burm.f.) and kigelia pinnata (jack.) Dc. International journal of Pharmaceutical research and development. (ijprd.com/Article_No_331_May_11_01.html).
  12. Md Masud Parvez, Md. Arifur Rahman, Md. Khosruzzaman Molla, and Md Al Amin   Sikder. 2011. Antimicrobial Activity and Cytotoxicity of Seed Extracts of Mesua  nagassarium (Burm.f.). International journal of Pharmaceutical research and development.   IJPRD, 2011; Vol 3(8): November 2011 (13 – 18).
  13.  Md. Al Amin Sikder, Mohammad A.Kaisar, Md. Kowser Miah, A.K. M. Nawshad Hossian, Md Masud Parvez, and Mohammad A. Rashid, 2011. Antioxidant Behavior of Two Bangladeshi Medicinal Plants: Kigelia pinnata and Mesua nagassarium. Bangladesh Pharmaceutical Society Journal, 14(Nov):05.
  14. Md Masud Parvez, Md. Khosruzzaman Molla, Md. Arifur Rahman, and Md. Mehedi hasan. In-vitro evaluation of the Antifungal activity of leaf extracts of Mesua nagassarium (Burm.f.) and Kigelia pinnata. IJPRD, 2011; Vol 3(12): February-2012 (19 – 24).
  15. Md Masud Parvez, Md. Arifur Rahman, Md. Khosruzzaman Molla, and Amena Akter.   Compound Isolation and purification by Chromatographic Method of Stem Bark of   Anisoptera scaphula (Roxb.). Journal of Pharma research and Clinical Practice (2012).

Contact:

Telephone: (509) 368-6535

Email: mdmasud.parvez@wsu.edu

Office Location: Pharmaceutical & Biomedical Sciences Building, Room # PBS-320