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Publications

2026

Rani, A.; Bisen, S.; Sharma, R.; Dar, AI.; Dhull, A.; Palmer, NJ.; Singh, NK.; Sharma, A. Systemic targeting of aberrant neovascular tufts using trehalose-dendrimer nanocarriers for the treatment of proliferative retinopathies. Theranostics 2026, 16(3):1504-1527 https://www.thno.org/v16p1504.htm

Vyas, P.; Khoury, ES.; Sah, N.; Sharma, A.; Labastida, JA.; Wilkinson, EL.; Lac, K.; Damiba, N.; Fowler, A.; Liu, J.; Bedner, A.; Majer, P.; Tichý, T.; Thomas, AG.; Rais, R.; Slusher, BS.; Kannan, RM.; Kannan, S. Dendrimer-conjugated glutamine antagonist, D-TTM020, ameliorates brain immune dysregulation and improves neurobehavioral deficits in Mecp2 deficient mouse model. Cells, 2026, 15(3):272.

2025

Dhull, A.; Pulukuri, AJ.; Dar, AI.; Palmer, NJ.; Gonzalez, J.; Sharma, R.; Berkman, CE.; Sharma, A*. Prostate-Specific Membrane Antigen (PSMA)-Directed Dendrimer–Camptothecin Conjugate for Targeted Treatment of Prostate Cancer. ACS Applied Nanomaterials; 2025, https://doi.org/10.1021/acsanm.5c03528

Pulukuri, AJ.; Dhull, A.; Dar, AI.; Sharma, R.; Berkman, CE.; Sharma, A*. Dendrimer-Mediated Delivery Enhances Therapeutic Efficacy in Triple-Negative Breast Cancer. Biomacromolecules; 2025, 26, 9, 5979–6000

Dar, AI.; Zhang, Z.; Gopalakishnan, S.; Sharma, R.; Castaneda, JG.; Rani, A.; Dhull, A.; Atoui, T.; Mashal, Y.; Naseer, Z.; Calmi, J.; Sharma, A*. Neuron-Targeted 2-Deoxyglucose-Dendrimer-Rosiglitazone Nanotherapy Mitigates Neuroinflammation and Cognitive Deficits in Pediatric Traumatic Brain Injury. Bioengineering & Translational Medicine, 2025, e70053. doi:10.1002/btm2.70053

Castaneda, JG.; Park, KW.; Evans,DB.; Sharma, R.; Sahaym, O.; Gopalakrishnan; S.; Dar, AI.; Valdez; T.; Sharma, A*. Nano approaches to gene delivery: barriers, solutions, and current landscape. Invited Review, WIRES Nanomedicine & Nanobiotechnology; 2025, 17(2):e70010.

Dar, AI.; Jain, V.; Castaneda, JG.; Dhull, A.; Sharma, A*. Silibinin Conjugated Galactose Dendrimers for Targeted Treatment of Hepatocellular Carcinoma. ACS Applied Materials & Interfaces, 2025, ; 17, 14, 20980–21000.

Dhull, A.; Park, KW.; Dar, AI.; Wang, A.; Rani, A.; Valdez, T.; Sharma, A*. Mixed-layered glycodendrimer probe for imaging inflammation at surgical site infections. ACS Sensors, 2025, 10, 3, 2234–2243.

2024

Rani, A.; Pulukuri, AJ.; Wei, J.; Dhull, A.; Sharma, R.; Mesbahi, N.; Savoy, EA.; Yoon, H.; Wu, BJ; Berkman CE.; Sharma, A*. PSMA-Targeted 2-Deoxyglucose-Based Dendrimer Nanomedicine for the Treatment of Prostate Cancer. Biomacromolecules, 2024, https://doi.org/10.1021/acs.biomac.4c00878

Dhull, A.; Zhang, Z.; Sharma, R.; Dar, AI.; Rani, R.; Wei, J.; Gopalakrishnan, S.; Ghannam, A.; Hahn, V.; Pulukuri, AJ.; Tasevski. S.; Moughni, S.; Wu, J.; Sharma, A* Discovery of 2-deoxy glucose surfaced mixed layer dendrimer: a smart neuron targeted systemic drug delivery system for brain diseases. Theranostics, 2024, 14(8): 3221-3245.

Dhull, A.; Wei, J.; Pulukuri, AJ.; Rani, A.; Sharma, R.; Mesbahi, N.; Yoon, H.; Savoy, EA.; Vi, SX.; Goody, KJ, Berkman CE.; Wu, BJ; Sharma, A*. PSMA-targeted dendrimer as an efficient anticancer drug delivery vehicle for prostate cancer. Nanoscale, 2024, doi.org/10.1039/D3NR06520K.

Kannan RM, Sharma, R.; Sharma, A.; Kannan, S.; Z.; Kambhampati, SP. Dendrimer delivery system and methods of use thereof. US Patent number 11918657. Publication date 2024/3/5

Sharma, A.; Sah, N.; Sharma, R.; Vyas, P.; Liyanage, W.; Kannan, S.; Kannan RM. Development of a novel glucose‐dendrimer based therapeutic targeting hyperexcitable neurons in neurological disorders. Bioeng Transl Med. 2024;e10655.

2023

Dhull, A.; Yu, C.; Wilmoth, AH.; Chen, M.; Sharma, A.*; Yiu S.* Dendrimers in Corneal Drug Delivery: Recent Developments and Translational Opportunities. Pharmaceutics 2023, 15 (6), 1591.

Porterfield, JE.; Sharma, R.; Jimenez, AS.; McCracken, S.; Zhang, L.; An, HT.; Lee, S.; Kannan, S.; Sharma, A.*; Kannan, RM*. Galactosylated hydroxyl-polyamidoamine dendrimer targets hepatocytes and improves therapeutic outcomes in a severe model of acetaminophen poisoning-induced liver failure. BioEngineering & Translational Medicine; 2023, doi.org/10.1002/btm2.10486

Sah, N.; Zhang, Z.; Chime, S.; Fowler, A.; Mendez-Trendler A.; Sharma, A.; Kannan RM.; Slusher, B.; Kannan, S. Dendrimer-conjugated glutamate carboxypeptidae II inhibitor restores microglial changes in a rabbit model of cerebral palsy. Developmental Neuroscience 2023; 45:268–275.

Pitha, I.; Kambhampati, S.; Sharma, A.; Sharma, R.; McCrea, L.; Mozzer, A.; Kannan, RM. Targeted Microglial Attenuation through Dendrimer–Drug Conjugates Improves Glaucoma Neuroprotection. Biomacromolecules 2023, 24, 3, 1355–1365

Zhang, F.; Zhang, Z.; Alt, J.; Kambhampati, SP.; Sharma, A.; Singh, S.; Nance, E.; Thomas, AG.; Rojas, C.; Rais, R.; Slusher, BS.; Kannan, RM.; Kannan S. Dendrimer-enabled targeted delivery attenuates glutamate excitotoxicity and improves motor function in a rabbit model of cerebral palsy. Journal of Controlled Release, 2023, 358, 27-42.

Datta, S.; Cano, M.; Satyanarayana, G.; Liu, T.; Wang, L.; Wang, J.; Cheng, J.; Itoh, K.; Sharma, A.; Bhutto, I.; Kannan, RM.; Qian, J.; Sinha, D.; Handa, JT. Mitophagy initiates retrograde mitochondrial-nuclear signaling to guide retinal pigment cell heterogeneity. Autophagy, 2023 19:3, 966-983.

Khoury, ES.; Patel, RV.; O’Ferrall, C.; Fowler, A.; Sah, N.; Sharma, A.; Gupta, S.; Scafidi, S.; Kurtz, SJ.; Olmstead, SJ.; Kudchadkar, S.; Kannan RM.; Blue, ME.; Kannan, DS.Dendrimer nanotherapy targeting of glial dysfunction improves inflammation and neurobehavioral phenotype in adult female Mecp2-heterozygous mouse model of Rett syndrome. Journal of Neurochemistry; 2023, 1–14. https://doi.org/10.1111/jnc.15960.

Nemeth, CL.; Gӧk, Ö.; Tomlinson, SN.; Sharma, A.; Moser, AB.; Kannan, S.; Kannan, RM.; Fatemi, A. Targeted brain delivery of dendrimer-4-phenylbutyrate ameliorates neurological deficits in a long-term ABCD1-deficient mouse model of X-linked adrenoleukodystrophy. Neurotherapeutics 2023, 20, 272-283.

2022

Tallon, C.; Bell, BJ.; Sharma, A.; Pal, A.; Malvankar, MM.; Thomas, AG.; Yoo, S.; Hollinger, KR.; Coleman, K.; Wilkinson, EL.; Kannan, S.; Haughey, NJ.; Kannan, RM.; Rais, R.; Slusher, BS. Dendrimer-conjugated nSMase2 inhibitor reduces Tau propagation in mice. Pharmaceutics 2022, 14(10), 2066.

Hollinger, KR. $; Sharma, A.$; Tallon, C.; Lovell, L.; Thomas, AG.; Zhu, X.; Wiseman, R.; Wu, Y.; Kambhampati, SP.; Liaw, K.; Sharma, R.; Rojas, C.; Rais, R.; Kannan, S.; Kannan, RM.; Slusher, BS. Dendrimer-2PMPA selectively blocks upregulated microglial GCPII activity and improves cognition in a mouse model of multiple sclerosis. Nanotheranostics 2022, 6(2):126-142. doi:10.7150/ntno.63158.

Tallon, C.; Sharma, A.; Zhang, Z.; Thomas, G.; Donoghue, A.; Schulte, M.; Rojas, C.; Kambhampati, S.; Sharma, R.; Liaw, K.; Kannan, S.; Kannan, RM and Slusher, BS. Dendrimer-conjugated 2PMPA targets activated macrophages in muscle and improves function and innervation in the SOD1G93A mouse model of ALS. Neurotherapeutics, 2022, https://doi.org/10.1007/s13311-021-01159-7

2021

Sharma, A.; Sah, N.; Kannan, S.; and Kannan, RM. Targeted Drug Delivery for Maternal and Perinatal Health: Challenges and Opportunities. Advanced Drug Delivery Reviews 2021, 177, 113950.

Sharma, R.; Porterfield, J.E.; An, H.; Jimenez, A. S.; Lee, S.; Kannan, S.; Sharma, A.*; and Kannan, RM*. Rationally Designed Galactose Dendrimer for Hepatocyte-Specific Targeting and Intracellular Drug Delivery for the Treatment of Liver Disorders. Biomacromolecules 2021, 22(8), 3574-3589.

Sharma, R., Liaw, K. Sharma, A.; Jimenez, A.; Chang, M.; Salazar, S.; Amlani, I.; Kannan, S.; and Kannan, RM. Glycosylation of PAMAM dendrimers significantly improves tumor macrophage targeting and specificity in glioblastoma. Journal of Controlled Release 2021, 337, 179-192.

Shi, AC.; Khoury, ES.; Sah, N.; Fowler, A.; Liaw K.; Sharma, A.; Kannan, RM.; Kannan, S. Characterization of microglial phagocytosis and dendrimer nanoparticle uptake in a neonatal rabbit model of cerebral palsy. Precision Nanomedicine, 2021, 4(4), 840

Giuliano, K.; Etchill, E.; Zhou, X.; Lui, C.; Sharma, R. Fraser, CD.; Crawford, TC.; Wilson, MA.; Torres-Odio, S.; Blue, ME.; Troncoso, JC.; Kannan, S.; Johnston, MV.; Sharma, A.; Kannan, RM.; Baumgartner, WA.; Lawton, J. NMDA receptor antagonism for neuroprotection in a canine model of hypothermic circulatory arrest. Journal of Surgical Research 2021, 260, 177-189.

DeRidder, L.; Sharma, A.; Liaw, K.; Sharma, R.; John, J.; Kannan, S.; and Kannan, RM. Dendrimer-Tesaglitazar conjugate induces a phenotype shift of microglia and enhances β-amyloid phagocytosis. Nanoscale, 2021, 13(2), 939-952.

Liaw, K.; Sharma, R.; Sharma, A.; Salazar, S.; Appiani La Rosa, S.; and Kannan, RM. Systemic dendrimer delivery of triptolide to tumor-associated macrophages improves anti-tumor efficacy and reduces systemic toxicity in glioblastoma. Journal of Controlled Release, 2021, 329, 434-444.

Arteaga Cabeza, O.; Zhang, Z.; Smith, Khoury.; E; Sheldon, RA.; Sharma, A; Zhang, F.; Slusher, BS.; Kannan, RM.; Kannan, S.; Ferriero, DM. Neuroprotective effects of a dendrimer-based glutamate carboxypeptidase inhibitor on superoxide dismutase transgenic mice after neonatal hypoxic-ischemic brain injury. Neurobiology of Disease, 2021, 148, 105210.

2020

  1. Sharma, A.; Sharma, R.; Zhang, Z.; Liaw, K.; Kambhampati, SP.; Porterfield, JE.; Lin, KC.; DeRidder, LB.; Kannan, S.; and Kannan, RM. Dense hydroxyl polyethylene glycol dendrimer targets activated glia in multiple CNS disorders. Science Advances 2020, 6(4), eaay8514.
  2. Sharma, A.; Liaw, K.; Sharma, R.; Spriggs, S.; Appiani La Rosa, S.; Kannan, S.; and Kannan, RM. Dendrimer-mediated targeted delivery of rapamycin to tumor-associated macrophages improves systemic treatment of glioblastoma. Biomacromolecules, 2020, 21(12), 5148-5161.
  3. Liaw, K.; Reddy, R.; Sharma, A.; Li, J.; Chang, M.; Sharma, R.; Salazar, S.; Kannan, S.; and Kannan, RM. Targeted systemic dendrimer delivery of CSF‐1R inhibitor to tumor‐associated macrophages improves outcomes in orthotopic glioblastoma. Bioengineering & Translational Medicine 2020, 6(2):e10205
  4. Sharma, A.; Liaw, K.; Thomas, A.; Sharma, R.; Zhang, Z.; Kannan, S.; and Kannan, RM. Targeting mitochondria in tumor-associated macrophages using a dendrimer-conjugated TSPO ligand that stimulates antitumor signaling in glioblastoma. Biomacromolecules 2020, 21(9): 3909-3922
  5. Khoury, ES.; Sharma, A.; Reddy, R.; Thomas, AG.; Liaw, K.; Rais, R.; Blue, ME.; Slusher, BS.; Kannan, S.; Kannan, RM. Dendrimer-mediated glutaminase inhibition effectively targets microglial glutaminase in a mouse model of Rett syndrome. Theranostics 2020 10(13):5736-5748.
  6. Nemeth, C. L.; Tomlinson, S. N.; Sharma, R.; Sharma, A.; Kannan, S.; Kannan, RM.; Fatemi, A. Glial restricted precursor delivery of dendrimer N-acetylcysteine promotes migration and differentiation following transplant in mouse white matter injury model. Nanoscale, 2020, 12: 16063-16068.
  7. Sharma, R.; Kambhampati, S.; Zhang, Z.; Sharma, A.; Chen, S.; Duh, E.; Kannan, S.; Tso, M.; Kannan, RM. Dendrimer mediated targeted delivery of sinomenine for the treatment of acute neuroinflammation in traumatic brain injury. Journal of Controlled Release, 2020, 323 (10), 361-375.
  8. Hollinger, K.; Sharma, A.; Tallon, C.; Lovell, L.; Thomas, A.G.; Zhu, X.; Kambhampati, SP.; Liaw, K.; Sharma, R.; Rojas, C.; Rais, R.; Kannan, S.; Kannan, RM.; and Slusher, BS. Microglia-targeted dendrimer-2PMPA therapy robustly inhibits GCPII and improves cognition in a mouse model of multiple sclerosis. bioRxiv, 2020, doi.org/10.1101/2020.04.22.055228.

2018

  1. Sharma, A.; Liaw, K.; Sharma, R.; Zhang, Z.; Kannan, S.; and Kannan, RM. Targeting Mitochondrial Dysfunction and Oxidative Stress in Activated Microglia Using Dendrimer-Based Therapeutics. Theranostics 2018, 8 (20), 5529-5547.
  2. Sharma, A.; Porterfield, J.; Smith, E.; Sharma, R; Kannan, S.; and Kannan, RM. Effect of mannose targeting of hydroxyl PAMAM dendrimers on cellular and organ biodistribution in a neonatal brain injury model. Journal of Controlled Release 2018, 283, 175-189.
  3. Sharma, R.; Sharma, A.; Kambhampati, S.; Reddy R. R.; Zhang, Z.; Cleland J. L.; Kannan, S.; and Kannan, RM. Scalable Synthesis and Validation of PAMAM Dendrimer‐N‐acetyl cysteine Conjugate for Potential Translation. Bioengineering and Translational Medicine 2018, 3(2): 87–101 doi.org/10.1002/btm2.10094.

2017

  1. Sharma, R.; Kim, S.; Sharma, A.; Zhang, Z.; Kambhampati, S.; Kannan, S.; and Kannan, RM. Activated microglia targeting dendrimer-minocycline conjugate as therapeutics for neuroinflammation. Bioconjugate Chemistry 2017, 28 (11), 2874.
  2. Sharma, A.; Sharma, R.; Abouelmagd, A.; Kakkar, A., CHAPTER 6 Synthetic articulation of miktoarm polymers for applications in biology. In Miktoarm Star Polymers: From Basics of Branched Architecture to Synthesis, Self-assembly and Applications, The Royal Society of Chemistry: 2017; pp 150-180.

2010-2016

  1. Sharma, A.; Kakkar, A., Designing dendrimer and miktoarm polymer based multi-tasking nanocarriers for efficient medical therapy. Molecules 2015, 20 (9), 16987.
  2. Moquin, A.$; Sharma, A.$; Cui, Y.; Lau, A.; Maysinger, D.; Kakkar, A., Asymmetric AB3 miktoarm star polymers: synthesis, self-assembly, and study of micelle stability using AF4 for efficient drug delivery. Macromolecular Bioscience 2015,15 (12), 1744-1754.
  3. Sharma, A.; Mejía, D.; Regnaud, A.; Uhlig, N.; Li, C.-J.; Maysinger, D.; Kakkar, A., Combined A3 coupling and click chemistry approach for the synthesis of dendrimer-based biological tools. ACS Macro Letters 2014, 3 (10), 1079-1083.
  4. Sharma, A.; Mejia, D.; Maysinger, D.; Kakkar, A., Design and synthesis of multifunctional traceable dendrimers for visualizing drug delivery. RSC Advances 2014, 4 (37), 19242-19245.
  5. Soliman, G. M.*, Sharma, A.*, Cui, Y., Sharma, R., Kakkar, A.; Maysinger, D. Miktoarm star micelles containing curcumin reduce cell viability of sensitized glioblastoma. Journal of Nanomedicine and Biotherapeutic Discovery. 2014, 4, 124, doi:10.4172/2155-983X.1000124.
  6. Soliman, G. M.; Redon, R.; Sharma, A.; Mejía, D.; Maysinger, D.; Kakkar, A., Miktoarm star polymer based multifunctional traceable nanocarriers for efficient delivery of poorly water soluble pharmacological agents. Macromolecular Bioscience 2014, 14 (9), 1312-1324.
  7. Neibert, K.; Gosein, V.; Sharma, A.; Khan, M.; Whitehead, M. A.; Maysinger, D.; Kakkar, A., “Click” dendrimers as anti-inflammatory agents: with insights into their binding from molecular modeling studies. Molecular Pharmaceutics 2013,10 (6), 2502-2508.
  8. Sharma, A.; Soliman, G. M.; Al-Hajaj, N.; Sharma, R.; Maysinger, D.; Kakkar, A., Design and evaluation of multifunctional nanocarriers for selective delivery of coenzyme Q10 to mitochondria. Biomacromolecules 2012, 13 (1), 239-252. Among Journal’s Top 20 Most Downloaded Articles for the Months of Dec 2011/Jan/Feb/March2012.
  9. Soliman, G. M $; Sharma, A.$; Maysinger, D.; Kakkar, A., Dendrimers and miktoarm polymers based multivalent nanocarriers for efficient and targeted drug delivery. Chemical Communications 2011, 47 (34), 9572-9587.
  10. Sharma, A.; Neibert, K.; Sharma, R.; Hourani, R.; Maysinger, D.; Kakkar, A., Facile construction of multifunctional nanocarriers using sequential click chemistry for applications in biology. Macromolecules 2011, 44 (3), 521-529. Among Journal’s Top 20 Most Downloaded Articles for the Months of January to March 2012.
  11. Sharma, A.*; Khatchadourian, A.*; Khanna, K.; Sharma, R.; Kakkar, A.; Maysinger, D., Multivalent niacin nanoconjugates for delivery to cytoplasmic lipid droplets. Biomaterials 2011,32 (5), 1419-1429. Cited in NewsRx April 6, 2011: Research from McGill University Provides New Data on Cytoplasmic Structures.
  12. Hourani, R.; Sharma, A.; Kakkar, A., Designing dendritic frameworks using versatile building blocks suitable for CuI-catalyzed alkyne azide ‘click’ chemistry. Tetrahedron Letters 2010, 51 (29), 3792-3795.