{"id":20,"date":"2018-06-06T08:15:15","date_gmt":"2018-06-06T15:15:15","guid":{"rendered":"http:\/\/labs.wsu.edu\/smerdon\/?page_id=20"},"modified":"2018-06-08T14:40:28","modified_gmt":"2018-06-08T21:40:28","slug":"lab-history","status":"publish","type":"page","link":"https:\/\/labs.wsu.edu\/smerdon\/lab-history\/","title":{"rendered":"Lab History"},"content":{"rendered":"<br \/>\n<section id=\"builder-section-1528297966670\" class=\"row single gutter pad-top\">\n<div style=\"\" class=\"column one \">\n<header>\n<h2>Lab History<\/h2>\n<\/header>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-72 aligncenter\" src=\"https:\/\/s3.wp.wsu.edu\/uploads\/sites\/2130\/2018\/06\/Slide1.png\" alt=\"\" width=\"551\" height=\"474\" srcset=\"https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/2130\/2018\/06\/Slide1.png 551w, https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/2130\/2018\/06\/Slide1-396x341.png 396w\" sizes=\"(max-width: 551px) 100vw, 551px\" \/><\/p>\n<p style=\"font-weight: 400\">It has been over four decades since Drs. Smerdon and Lieberman published their groundbreaking\u00a0paper demonstrating that significant structural rearrangements occur at the nucleosome level\u00a0of chromatin during nucleotide excision repair (NER) of DNA damage in human cells (Smerdon and Lieberman, 1978,\u00a0<em>Proc. Natl. Acad. Sci. USA<\/em>\u00a0<strong>75<\/strong>: 4238). Understanding the\u00a0mechanism(s) of this rearrangement process has been one of the goals of the Smerdon lab ever since. It\u00a0was clear from the beginning that DNA repair must take place throughout the genome, within all\u00a0levels of the chromatin packaging hierarchy, since no region within chromatin is fully\u00a0protected from exogenous and\/or endogenous DNA damage. In 1987, the Smerdon lab reported that UV light-Induced DNA damage is strongly modulated by the packaging of DNA into nucleosomes (Gale et al., 1987,\u00a0<em>Proc. Natl. Acad.<\/em>\u00a0<em>Sci. USA\u00a0<\/em>\u00a0<strong>84<\/strong>: 6644). This report helped set the stage for our understanding that\u00a0<em>both<\/em>\u00a0DNA damage and DNA repair can be strongly modulated by the packaging of DNA in chromatin.<\/p>\n<p style=\"font-weight: 400\">New technological advances led to a more comprehensive understanding of\u00a0these findings, and during the past two decades there was a significant increase in research focused directly\u00a0on DNA repair and chromatin (Figure 1). Some of this renewed interest was the result of an increased\u00a0understanding of how proteins involved in transcription interact with nucleosomes (e.g., see Meijer and Smerdon, 1999,\u00a0<em>BioEssays<\/em>\u00a0<strong>21<\/strong>, 596). There is now convincing evidence that nucleosome modifications and rearrangements are\u00a0required for efficient transcriptional processing of DNA. Since the late 70s, the Smerdon lab has focused on correlations between DNA damage, DNA repair, gene transcription and chromatin structure. Comprehensive reviews on the work done in this lab can be found in\u00a0Smerdon and Conconi (1999)\u00a0<em>Prog. Nucl. Acid Res. Mol. Biol.<\/em>,\u00a0<strong>62<\/strong>: 227, Rodriguez et al. (2015) DNA Repair <strong>32<\/strong>: 113 and Mao et al. (2017) Photochem. Photobiol. <strong>93<\/strong>: 216.<\/p>\n<\/p><\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p> <\/p>\n<h2>Lab History<\/h2>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-72 aligncenter\" src=\"https:\/\/s3.wp.wsu.edu\/uploads\/sites\/2130\/2018\/06\/Slide1.png\" alt=\"\" width=\"551\" height=\"474\" srcset=\"https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/2130\/2018\/06\/Slide1.png 551w, https:\/\/wpcdn.web.wsu.edu\/wp-labs\/uploads\/sites\/2130\/2018\/06\/Slide1-396x341.png 396w\" sizes=\"(max-width: 551px) 100vw, 551px\" \/><\/p>\n<p style=\"font-weight: 400\">It has been over four decades since Drs. Smerdon and Lieberman published their groundbreaking\u00a0paper demonstrating that significant structural rearrangements occur at the nucleosome level\u00a0of chromatin during nucleotide excision repair (NER) of DNA damage in human cells (Smerdon and Lieberman, 1978,\u00a0<em>Proc. Natl. Acad. Sci. USA<\/em>\u00a0<strong>75<\/strong>: 4238). Understanding the\u00a0mechanism(s) of this rearrangement process has been one of the goals of the Smerdon lab ever since. It\u00a0was clear from the beginning that DNA repair must take place throughout the genome, within all\u00a0levels &#8230; <a href=\"https:\/\/labs.wsu.edu\/smerdon\/lab-history\/\" class=\"more-link\"><span class=\"more-default\">&raquo; More &#8230;<\/span><\/a><\/p>\n","protected":false},"author":4447,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-builder.php","meta":{"_wsuwp_accessibility_report":[]},"wsuwp_university_location":[],"wsuwp_university_org":[],"_links":{"self":[{"href":"https:\/\/labs.wsu.edu\/smerdon\/wp-json\/wp\/v2\/pages\/20"}],"collection":[{"href":"https:\/\/labs.wsu.edu\/smerdon\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.wsu.edu\/smerdon\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.wsu.edu\/smerdon\/wp-json\/wp\/v2\/users\/4447"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.wsu.edu\/smerdon\/wp-json\/wp\/v2\/comments?post=20"}],"version-history":[{"count":8,"href":"https:\/\/labs.wsu.edu\/smerdon\/wp-json\/wp\/v2\/pages\/20\/revisions"}],"predecessor-version":[{"id":74,"href":"https:\/\/labs.wsu.edu\/smerdon\/wp-json\/wp\/v2\/pages\/20\/revisions\/74"}],"wp:attachment":[{"href":"https:\/\/labs.wsu.edu\/smerdon\/wp-json\/wp\/v2\/media?parent=20"}],"wp:term":[{"taxonomy":"wsuwp_university_location","embeddable":true,"href":"https:\/\/labs.wsu.edu\/smerdon\/wp-json\/wp\/v2\/wsuwp_university_location?post=20"},{"taxonomy":"wsuwp_university_org","embeddable":true,"href":"https:\/\/labs.wsu.edu\/smerdon\/wp-json\/wp\/v2\/wsuwp_university_org?post=20"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}