Sleep and Performance Research Center
Neuroendocrinology and Circadian Biology
Ilia Karatsoreos, Ph.D.
AREAS OF INTEREST
Circadian Rhythms, Stress, Obesity, Neural Plasticity, Learning and Memory, Immune Function
In our modern industrialized society, we have altered the relationship between our circadian (daily) body clock and the day-night cycle. In many cases we are active long into the night and sleep during the day. In extreme situations, such as shift-workers and trans-meridian air travelers (e.g. jet-lag), overriding circadian rhythms can be more than just a nuisance, and lead to health problems. These problems can include metabolic syndrome, increased risk of heart disease, higher incidences of certain types of cancer, disrupted immune responses, and increased risk of suffering from depression or anxiety.
Effects of sleep and circadian disruption on brain, behavior, and physiology
We focus on the relationship between circadian rhythms, sleep, and mental and physical health. We are particularly interested in how disruption of the circadian clock leads to negative health outcomes by making individuals less resilient to other challenges in the environment, like stress, immune challenge, and changes in diet. It is hoped these models will provide an understanding of how dysregulation of the body’s timing interact to produce changes in behavior and physiology, and will potentially lead to new clinical interventions to alleviate some of the physical and mental health consequences of our modern lifestyles.
STAFF AND TRAINEES
- Marina Savenkova, Ph.D. (Laboratory manager)
- Derrick Phillips, M.S. (Graduate Student, Neuroscience)
- Scott Kinlein, B.Sc. (Graduate Student, Neuroscience)
- Circadian rhythms analysis
- Sleep neurophysiology
- Whole animal metabolic function
- Brain metabolism
- Neural morphology
- Gene expression analysis (qPCR, RNAseq)
- NATIONAL INSTITUTES OF HEALTH
- NARSAD YOUNG INVESTIGATOR GRANT