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Sleep and Performance Research Center

Neuroendocrinology and Circadian Biology

Ilia Karatsoreos, Ph.D.

AREAS OF INTEREST

Circadian Rhythms, Stress, Obesity, Neural Plasticity, Learning and Memory, Immune Function

RESEARCH SCOPE

In our modern industrialized society, we have altered the relationship between our circadian (daily) body clock and the day-night cycle. In many cases we are active long into the night and sleep during the day. In extreme situations, such as shift-workers and trans-meridian air travelers (e.g. jet-lag), overriding circadian rhythms can be more than just a nuisance, and lead to health problems. These problems can include metabolic syndrome, increased risk of heart disease, higher incidences of certain types of cancer, disrupted immune responses, and increased risk of suffering from depression or anxiety.

RESEARCH FOCUS

Effects of sleep and circadian disruption on brain, behavior, and physiology

We focus on the relationship between circadian rhythms, sleep, and mental and physical health. We are particularly interested in how disruption of the circadian clock leads to negative health outcomes by making individuals less resilient to other challenges in the environment, like stress, immune challenge, and changes in diet. It is hoped these models will provide an understanding of how dysregulation of the body’s timing interact to produce changes in behavior and physiology, and will potentially lead to new clinical interventions to alleviate some of the physical and mental health consequences of our modern lifestyles.

STAFF AND TRAINEES

Dr. Marina Savenkova, Ph.D. (Laboratory manager)
Mr. Derrick Phillips, M.S. (Graduate Student, Neuroscience)
Mr. Scott Kinlein, B.Sc. (Graduate Student, Neuroscience)

APPROACHES USED

Circadian rhythms analysis
Sleep neurophysiology
Whole animal metabolic function
Brain metabolism
Neural morphology
Immunohistochemistry
Gene expression analysis (qPCR, RNAseq)

GRANT SUPPORT

  • NATIONAL INSTITUTES OF HEALTH
    • NINDS
    • NIMH
    • NIDA
  • NARSAD YOUNG INVESTIGATOR GRANT

PUBLICATIONS

http://www.ncbi.nlm.nih.gov
 
 
Chart showing overlapping areas of the lab