Skip to main content Skip to navigation

Sleep and Performance Research Center

Experimental and Clinical Stress and Sleep

Janne Grønli, Ph.D.

AREAS OF INTEREST

Sleep, Stress, Circadian Rhythms, Neural Plasticity, Metabolism, Shift Work, Light Exposure, Mental Health

RESEARCH SCOPE

Many people report that they feel stress due to perceived demands that exceed their resources. Stress is inevitable and has many (positive and negative) effects on the central nervous system. Negative stress exposure comprises prenatal stress, early life stress, stress in adolescence and adult life which may be acute or chronic or of more traumatic character. The most common negative effects associated with stress are disturbances in sleep, brain functioning and metabolism as well as increased risk of suffering from depression, anxiety, addiction and gastrointestinal distress. My research scope is basic research and translational research related the stress- sleep interactions, their consequences for our health and disease – mental and physical.

RESEARCH FOCUS

During my stay at WSU, I am working in close collaboration with Dr. Jonathan Wisor on projects aimed at characterizing the critical function of sleep in ensuring metabolic homeostasis within the cerebral cortex. In particular, we are exploring how chronic use of methamphetamine causes hypersomnolence and cerebral hypermetabolism at the synaptic level.

At the University of Bergen, my lab investigates the impact of stress and work load on sleep and circadian rhythms (and synaptic plasticity). We employ various paradigms that rely either on acute or chronic, predictable (controllable) or unpredictable (uncontrollable) stress/work load, in different phases in life. The sleep-stress interaction is examined at the behavioral level, on brain function and molecular changes at the translational level. The lab is also particularly interested in how (blue) light exposure is affecting sleep, circadian rhythms and mental health. Working with research partners, we perform clinical studies to apply the findings to issues related to human mental health. http://www.uib.no/en/ibmp

STAFF AND TRAINEES

Dr. Jelena Mrdalj, PhD (Senior Study Coordinator)
Iris Steine (PhD student)
Tone Blågestad (PhD student)
Andrea Marti (Master student)
Torhild Pedersen, MSc
Anne Marie Kinn Rød, PhD (Senior engineer)

APPROACHES USED

EEG/EMG analysis; sleep staging and EEG power
Circadian rhythms analysis
Behavior
Brain metabolism
Immunoassays
Radioimmunoassays
Bloodspot
Polysomnography
Actigraphy
Sleep questionnaires

GRANT SUPPORT

  • Norwegian Research Council Board of Mental Health
  • Helse Vest Regional Health Authority
  • Norwegian Competence Center for Sleep Disorders
  • Meltzer Foundation

PUBLICATIONS

NIH Bibliography