{"id":1590,"date":"2023-12-30T18:15:28","date_gmt":"2023-12-31T02:15:28","guid":{"rendered":"http:\/\/labs.wsu.edu\/sprc\/?page_id=1590"},"modified":"2024-05-31T10:18:31","modified_gmt":"2024-05-31T17:18:31","slug":"yool-lee","status":"publish","type":"page","link":"https:\/\/labs.wsu.edu\/sprc\/faculty\/yool-lee\/","title":{"rendered":"Yool Lee, PhD"},"content":{"rendered":"
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Influence of Circadian Rhythms on Physiology, Diseases, and Therapeutic Interventions<\/h2>\n\n\n\n

Areas of Interest<\/h3>\n\n\n\n

Circadian rhythms, sleep deprivation and disorders, cancer evolution, neurodegenerative diseases, chronotherapy<\/p>\n\n\n\n

Research Scope<\/h3>\n\n\n\n

Circadian clocks represent cellular timing systems that generate 24-hour biological rhythms, a phenomenon conserved across diverse life forms, from unicellular organisms to humans. The internal body clock harmonizes with various environmental and metabolic stimuli, such as light and food, orchestrating daily behavioral rhythms (e.g., sleep\/wake and feeding cycles), physiological patterns (e.g., body temperature, hormonal and immune systems), and cellular processes (e.g., metabolic and cell cycle pathways). In modern society, factors that disrupt circadian rhythms, including sleep deprivation, jet lag, shift work, and aging, are recognized to increase susceptibility to metabolic disorders (e.g., cancers) and neurodegenerative conditions (e.g., Alzheimer\u2019s disease). Conversely, these pathological disorders increasingly reveal their impact on disrupting the sleep-wake cycle and circadian physiology. Therefore, a detailed understanding of the regulatory pathways of the circadian clock and their intricate interplay with various disease processes is crucial for the prevention and treatment of disorders associated with circadian dysregulation.<\/p>\n\n\n\n

Research Focus<\/h3>\n\n\n\n

Our laboratory research centers around three primary areas: (1) Understanding the biological mechanisms of circadian physiology and behaviors in animal and cellular models; (2) Investigating the molecular and cellular impact of circadian disruptions on tumor heterogeneity, tumor microenvironment, and metastatic progression in human and mouse cancer models; (3) Translational applications of circadian physiology for the treatment of cancer and aging-related pathologies using nutritional, metabolic, and pharmacological interventions.<\/p>\n\n\n\n

Staff<\/h3>\n\n\n\n

Prajakta Vaishampayan, M.S. (Scientific Assistant)<\/p>\n\n\n\n

Approaches Used<\/h3>\n\n\n\n