Zhaokang Cheng Lab
WSU Cardiovascular Research Laboratory
Washington State University (2016 – present):
- Liu Y, Chen J, Fontes SK, Bautista EN, Cheng Z. Physiological And Pathological Roles Of Protein Kinase A In The Heart. Cardiovasc Res. 2022 Jan 29;118(2):386-398.
Featured by: Editors’ Picks, - Antoniak S, Phungphong S, Cheng Z, Jensen BC. Novel Mechanisms of Anthracycline-Induced Cardiovascular Toxicity: A Focus on Thrombosis, Cardiac Atrophy, and Programmed Cell Death. Front Cardiovasc Med. 2022 Jan 17;8:817977.
- Liu Y, Chen J, Xia P, Stratakis CA, Cheng Z. Loss of PKA regulatory subunit 1α aggravates cardiomyocyte necrosis and myocardial ischemia/reperfusion injury. J Biol Chem. 2021 Jun 1; 297(1):100850.
Featured by: Science Daily, Medical Express, KXLY Local News, WSU Insider. - Liu Y, Xia P, Chen J, Bandettini WP, Kirschner LS, Stratakis CA, Cheng Z. PRKAR1A deficiency impedes hypertrophy and reduces heart size. Physiol Rep. 2020 Mar;8(6):e14405.
- Xia P, Chen J, Liu Y, Fletcher M, Jensen BC, Cheng Z. Doxorubicin induces cardiomyocyte apoptosis and atrophy through cyclin-dependent kinase 2-mediated activation of forkhead box O1. J Biol Chem. 2020 Mar 27;295(13):4265-4276.
Featured by: Science Daily, Oncology News, Medical Express, News Medical, Cardiovascular Health, Scienmag, Science Codex, The Daily Evergreen, Pharmacy Times, WSU Insider. - Dakup PP, Porter KI, Gajula RP, Goel PN, Cheng Z, Gaddameedhi S. The circadian clock protects against ionizing radiation-induced cardiotoxicity. FASEB J. 2020 Feb;34(2):3347-3358.
Featured by: National Heart, Lung, and Blood Institute (NHLBI) News, Science Daily, Medical Express, News Medical, Science Blog, Spokesman Review, The Columbian, WSU Insider. - Xia P, Liu Y, Chen J, Cheng Z. Cell cycle proteins as key regulators of postmitotic cell death. Yale J Biol Med. 2019 Dec 20;92(4):641-650.
- Cheng Z, Combs M, Zhu Q, Xia P, Opheim Z, Parker J, Mack CP, Taylor JM. Genome-wide RNAi screen identifies regulators of cardiomyocyte necrosis. ACS Pharmacol Transl Sci. 2019; 2(5): 361-371.
- Xia P, Liu Y, Chen J, Coates S, Liu DX, Cheng Z. Inhibition of cyclin-dependent kinase 2 protects against doxorubicin-induced cardiomyocyte apoptosis and cardiomyopathy. J Biol Chem. 2018 Dec 21;293(51):19672-19685.
Featured by: Science Daily, eCancer News, Medical Express, News Medical, Cardiovascular Business, Health Canal, WSU Insider. - Cheng Z, Zhu Q, Dee R, Opheim Z, Mack CP, Cyr DM, Taylor JM. Focal adhesion kinase-mediated phosphorylation of Beclin1 suppresses cardiomyocyte autophagy and initiates hypertrophic growth. J Biol Chem. 2017;292(6):2065-2079.
Featured by: JBC Editors’ Picks, JBC Author Profile. - Xia P, Liu Y, Cheng Z. Signaling Pathways in Cardiac Myocyte Apoptosis. Biomed Res Int. 2016:9583268.
University of North Carolina, Chapel Hill (2010 – 2016):
- Lenhart KC, O’Neill TJ 4th, Cheng Z, Dee R, Demonbreun AR, Li J, Xiao X, McNally EM, Mack CP, Taylor JM. GRAF1 deficiency blunts sarcolemmal injury repair and exacerbates cardiac and skeletal muscle pathology in dystrophin-deficient mice. Skeletal Muscle. 2015;5:27.
- Cheng Z, DiMichele LA, Rojas M, Vaziri C, Mack CP, Taylor JM. Focal adhesion kinase antagonizes doxorubicin cardiotoxicity via p21(Cip1.) J Mol Cell Cardiol. 2014;67:1-11.
- Liu Y, Ye X, Mao L, Cheng Z, Yao X, Jia X, Mao D, Ou L, Li Z, Che Y, Liu N, Steinhoff G, Liu L, Kong D. Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac dysfunction and remodelling after myocardial infarction. Cardiovasc Res. 2013;97(2):208-18.
- Cheng Z, DiMichele LA, Hakim ZS, Rojas M, Mack CP, Taylor JM. Targeted focal adhesion kinase activation in cardiomyocytes protects the heart from ischemia/reperfusion injury. Arterioscler Thromb Vasc Biol. 2012;32(4):924-33.
Featured by: Science Daily, MPR News, ZeeNews, LabMedica, TopNews NZ, Endeavors, Clarksville Online, UNC Health Care Newsroom. - Liu X, Duan B, Cheng Z, Jia X, Mao L, Fu H, Che Y, Ou L, Liu L, Kong D. SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion. Protein Cell. 2011;2(10):845-54.
- Cheng Z, Sundberg-Smith LJ, Mangiante LE, Sayers RL, Hakim ZS, Musunuri S, Maguire CT, Majesky MW, Zhou Z, Mack CP, Taylor JM. Focal adhesion kinase regulates smooth muscle cell recruitment to the developing vasculature. Arterioscler Thromb Vasc Biol. 2011;31(10):2193-202.
San Diego State University (2008 – 2010):
- Sussman MA, Völkers M, Fischer K, Bailey B, Cottage CT, Din S, Gude N, Avitabile D, Alvarez R, Sundararaman B, Quijada P, Mason M, Konstandin MH, Malhowski A, Cheng Z, Khan M, McGregor M. Myocardial AKT: the omnipresent nexus. Physiol Rev. 2011;91(3):1023-70.
- Avitabile D, Bailey B, Cottage CT, Sundararaman B, Joyo A, McGregor M, Gude N, Truffa S, Zarrabi A, Konstandin M, Khan M, Mohsin S, Völkers M, Toko H, Mason M, Cheng Z, Din S, Alvarez R Jr, Fischer K, Sussman MA. Nucleolar stress is an early response to myocardial damage involving nucleolar proteins nucleostemin and nucleophosmin. Proc Natl Acad Sci U S A. 2011;108(15):6145-50.
- Cheng Z, Völkers M, Din S, Avitabile D, Khan M, Gude N, Mohsin S, Bo T, Truffa S, Alvarez R, Mason M, Fischer KM, Konstandin MH, Zhang XK, Heller Brown J, Sussman MA. Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis. Eur Heart J. 2011;32(17):2179-88.
Nankai University (2003 – 2008):
- Cheng Z, Ou L, Liu Y, Liu X, Li F, Sun B, Che Y, Kong D, Yu Y, Steinhoff G. Granulocyte colony-stimulating factor exacerbates cardiac fibrosis after myocardial infarction in a rat model of permanent occlusion. Cardiovasc Res. 2008;80(3):425-34.
- Cheng Z, Liu X, Ou L, Zhou X, Liu Y, Jia X, Zhang J, Li Y, Kong D. Mobilization of mesenchymal stem cells by granulocyte colony-stimulating factor in rats with acute myocardial infarction. Cardiovasc Drugs Ther. 2008;22(5):363-71.
- Cheng Z, Ou L, Zhou X, Li F, Jia X, Zhang Y, Liu X, Li Y, Ward CA, Melo LG, Kong D. Targeted migration of mesenchymal stem cells modified with CXCR4 gene to infarcted myocardium improves cardiac performance. Mol Ther. 2008;16(3):571-9.
View complete list of publications from PubMed