Population Genomics of microorganisms and their hosts in health and disease
Our ability to understand how pathogens and hosts have adapted to each other, requires a deep understanding of how basic evolutionary processes that have shaped the genetic architecture of these organisms. In my research, we use a multidisciplinary approach that combines computational biology, population genetic/genomic analyses, phylogenetics, simple mathematical modeling, and wet lab experiments to address these issues. Developing a better understanding of the forces shaping the genetic architecture of organisms will have enormous implications on the design of strategies for the management of populations and species of interest. We use genomic data to infer the demographic history of populations and use these demographics to better understand how selection has shaped specific regions of the genome to contribute to species adaptations.
We are interested in the inference of the evolutionary history of populations and how genomic data can be used to learn. We apply these methods to answer questions in different systems: i) Humans; ii) Microbiomes; iii) Malarial parasites; and iv) Plants. Yet the questions addressed in these systems are similar in nature. Some of the questions we address in our research are:
- How are microbiomes structured by host genetics and the physiological niche created by the host?
- How do differences in microbiome composition modulate phenotypes in hosts?
- How important is homologous recombination for the evolution of traits involved in host shifts or adaptation to new environments in microbes and hosts?
- During which stages of the complex life cycle of organisms do we expect to find hotspots of adaptation?
- How has the demographics impacts the accumulation of deleterious mutations, impacting the fitness of individuals?
We are experts in the generation and analysis of next generation sequencing data and we provide a great learning environment for students and postdocs with a quantitative inclination. You can learn more about what we do in our lab in the Research section.
Some of the questions currently addressed in our lab can be more thoroughly explored in our Research Areas. If you are interested in any of these research topics do not hesitate to contact us. For more information on the opportunities in for Undergraduate, Graduate and Postodoctoral positions visit our Opportunities section.
WSU VP of Research Visits the Lab:
Cacao in the news:
The evolutionary genomics of the chocolate tree, Theobroma cacao
The lab in the WSU news
Our recent work on Gardnerella vaginalis in collaboration with Larry Forney is out (check it out)
The Cornejo Lab joins Ag1000 to help contribute to improve human health