3d illustration of the human microbiome in a black background.
Shen Lab
The Microbiome in Human Health and Disease

Our mission

We coexist with trillions of microbes that inhabit our bodies, collectively known as the microbiome. The microbiome interacts closely with its host—shaping metabolism, modulating the immune system, and helping maintain homeostasis. Our laboratory aims to uncover how these host–microbiome interactions shape health and disease using genomics and bioinformatics approaches, with the ultimate goal of revealing disease mechanisms and guiding the development of more effective preventive and therapeutic strategies.

Research

An artistic image shows the gut surrounded by microbes on the left and a woman touching her face with microbes on the other side of the face on the right.

Gut-skin axis

Investigating connections between the skin and gut through host–microbiome interactions.

A photo of a person with atopic dermatitis scratching the right forearm.

Microbiome in atopic dermatitis

Understanding the role of the microbiome in the mechanisms of atopic dermatitis.

Artistic rendering of dna. Color scheme is blue.

Computational methods

Developing novel bioinformatic approaches to advance the analysis of microbiome data.