Sex Steroid Hormones & Female Reproductive Biology
There are multiple components of the cells in that female reproductive tract that work in concert to provide optimal microenvironment for gametes (eggs and sperm) and embryos to establish successful pregnancy. At Winuthayanon Lab, we focus on studying how ovarian steroid hormones (estrogen and progesterone) affect fertility during sperm migration, fertilization, embryo development, and embryo transport within the female reproductive tract. We use genetic-engineered mouse models to dissect the molecular mechanisms and functional requirement of estrogen and progesterone signals through their classical nuclear receptors (estrogen receptor; ESR1 and progesterone receptor; PGR) during early pregnancy. Our research aims to provide fundamental knowledge in reproductive biology during early pregnancy as well as potential contraceptive targets for women and therapeutic approaches for infertility in humans.
Dr. Winuthayanon received the SMB Excellence in Undergraduate Mentoring Award, 05/09/2020
Our lab received the Largest New Individual Grant Award, a Recognition from WSU Office of Research
In FY2019, Winuthayanon received a $1.59 million award from the National Institutes of Health (NIH) to study the oviductal epithelium environment to tackle the poor success and inherent problems associated with assisted reproductive technologies (ART). – By Karen Hunt, Office of Research
Ciliary beating in the mouse oviduct
It is incredible how different epithelial cell types in different tissues work! This video shows the beating of ciliated epithelial cells from the mouse oviduct collected on the first day of pregnancy (right after fertilization). The cilia beat in a unidirectional fashion to propel the fluid (and potentially embryo) from the oviduct to the uterus. The video was recorded real-time at 100 frames/second for 10 seconds.
For a mammal’s sperm to succeed, it must complete the swim of its life to reach and fertilize an egg. That’s easier if it swims through water, not goo!!!
Story By Eric Sorensen, WSU science writer
A method to collect the semen from the female reproductive tract, check it out!
Full publication here PDF.