Publications

  • Nagao I, Nakazawa M, Tachibana Y, Kawasaki M, Ambrosini YM. Assessment of P-Glycoprotein Function Using Canine Intestinal Organoid-Derived Epithelial Interfaces. Xenobiotica, 1–11. (2024). https://doi.org/10.1080/00498254.2024.2358395
  • Kawasaki M, McConnel CS, Burbick CR, Ambrosini YM. Pathogen-Epithelium Interactions and Inflammatory Responses in Salmonella Dublin Infections through Bovine Ileal Monolayer Models Derived from Adult Bovine Organoids. Sci Rep 14, 11479 (2024). https://doi.org/10.1038/s41598-024-62407-2
  • Kawasaki M and Ambrosini YM. Differential Colonization and Mucus Ultrastructure Visualization in Bovine Ileal and Rectal Organoid-Derived Monolayers Exposed to Enterohemorrhagic Escherichia coli. Int. J. Mol. Sci. 2024, 25(9), 4914 https://doi.org/10.3390/ijms25094914 
  • Nagao I and Ambrosini YM. High-Fat Diet Enhances Cell Proliferation and Compromises Intestinal Permeability in A Translational Canine Intestinal Organoid Model. BMC Molecular and Cell Biology (2024) 25:14. https://doi.org/10.1186/s12860-024-00512-w
  • Nagao, I.*, Nakazawa, M.*, Goyama, T., Court, M. H. and Ambrosini, Y. M. Assessment of Cytochrome P450 Induction in Canine Intestinal Organoid Models. Xenobiotica. (2024). doi: 10.1080/00498254.2024.2326973
  • Nagao, I., Nakazawa, M., Ambrosini, Y. M. Three-Dimensional Morphogenesis in Canine Gut-on-a-Chip Using Intestinal Organoids Derived from Inflammatory Bowel Disease Patients. J. Vis. Exp. (204), e65720, doi:10.3791/65720 (2024).
  • Kawasaki M, Dykstra GD, McConnel CS, Burbick CR, and Ambrosini YM. Adult Bovine-Derived Small and Large Intestinal Organoids: In Vitro Development and Maintenance. J of Tissue Eng. and Reg. Med. Volume 2023, Article ID 3095002, 12 pages. https://doi.org/10.1155/2023/3095002.
  • Nagao I, Ambrosini YM. Ion channel function in translational bovine gallbladder cholangiocyte organoids: establishment and characterization of a novel model system. Front. Vet. Sci. 2023 May 10:1179836. https://doi.org/10.3389/fvets.2023.1179836.
  • Kawasaki M, Goyama T, Tachibana Y, Nagao I, Ambrosini YM. Farm and Companion Animal Organoid Models in Translational Research: A Powerful Tool to Bridge the Gap Between Mice and Humans. Front Med Technol. 2022 May 12;4:895379. doi: 10.3389/fmedt.2022.895379. PMID: 35647577; PMCID: PMC9133531.
  • Ambrosini YM, Piedra-Mora C, Jennings S, Webster CRL. Serum 25-hydroxyvitamin D and C-reactive protein and plasma von Willebrand concentrations in 23 dogs with chronic hepatopathies. J Vet Intern Med. 2022 May;36(3):966-975. doi: 10.1111/jvim.16424. Epub 2022 Apr 14. PMID: 35420222; PMCID: PMC9151486.
  • Shin W, Ambrosini YM, Shin YC, Wu A, Min S, Koh D, Park S, Kim S, Koh H, Kim HJ. Robust Formation of an Epithelial Layer of Human Intestinal Organoids in a Polydimethylsiloxane-Based Gut-on-a-Chip Microdevice. Front Med Technol. 2020 Aug;2:2. doi: 10.3389/fmedt.2020.00002. Epub 2020 Aug 7. PMID: 33532747; PMCID: PMC7849371.
  • Ambrosini YM, Neuber S, Borcherding D, Seo YJ, Segarra S, Glanemann B, Garden OA, Müller U, Adam MG, Dang V, Borts D, Atherly T, Willette AA, Jergens A, Mochel JP, Allenspach K. Treatment With Hydrolyzed Diet Supplemented With Prebiotics and Glycosaminoglycans Alters Lipid Metabolism in Canine Inflammatory Bowel Disease. Front Vet Sci. 2020 Jul 30;7:451. doi: 10.3389/fvets.2020.00451. PMID: 32851029; PMCID: PMC7406657.
  • Shin YC, Shin W, Koh D, Wu A, Ambrosini YM, Min S, Eckhardt SG, Fleming RYD, Kim S, Park S, Koh H, Yoo TK, Kim HJ. Three-Dimensional Regeneration of Patient-Derived Intestinal Organoid Epithelium in a Physiodynamic Mucosal Interface-on-a-Chip. Micromachines (Basel). 2020 Jul 7;11(7):663. doi: 10.3390/mi11070663. PMID: 32645991; PMCID: PMC7408321.
  • Ambrosini YM, Park Y, Jergens AE, Shin W, Min S, Atherly T, Borcherding DC, Jang J, Allenspach K, Mochel JP, Kim HJ. Recapitulation of the accessible interface of biopsy-derived canine intestinal organoids to study epithelial-luminal interactions. PLOSOne. 2020 Apr 17;15(4):e0231423. doi: 10.1371/journal.pone.0231423. PMID: 32302323; PMCID: PMC7164685.
  • Ambrosini YM, Shin W, Min S, Kim HJ. Microphysiological Engineering of Immune Responses in Intestinal Inflammation. Immune Netw. 2020 Apr 8;20(2):e13. doi: 10.4110/in.2020.20.e13. PMID: 32395365; PMCID: PMC7192834.
  • Ullal T, Ambrosini Y, Rao S, Webster CRL, Twedt D. Retrospective evaluation of cyclosporine in the treatment of presumed idiopathic chronic hepatitis in dogs. J Vet Intern Med. 2019 Sep;33(5):2046-2056. doi: 10.1111/jvim.15591. Epub 2019 Aug 8. PMID: 31393054; PMCID: PMC6766481.
  • Ambrosini YM, Borcherding D, Kanthasamy A, Kim HJ, Willette AA, Jergens A, Allenspach K, Mochel JP. The Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review. Front Aging Neurosci. 2019 Jun 18;11:130. doi: 10.3389/fnagi.2019.00130. PMID: 31275138; PMCID: PMC6591269.
  • Chandra L, Borcherding DC, Kingsbury D, Atherly T, Ambrosini YM, Bourgois-Mochel A, Yuan W, Kimber M, Qi Y, Wang Q, Wannemuehler M, Ellinwood NM, Snella E, Martin M, Skala M, Meyerholz D, Estes M, Fernandez-Zapico ME, Jergens AE, Mochel JP, Allenspach K. Derivation of adult canine intestinal organoids for translational research in gastroenterology. BMC Biol. 2019 Apr 11;17(1):33. doi: 10.1186/s12915-019-0652-6. PMID: 30975131; PMCID: PMC6460554.