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CAE Lab Publications

Books

  • X. L. Chen and Y. J. Liu, “Finite Element Modeling and Simulation with ANSYS Workbench”, 2nd ed. Boca Raton, Florida: CRC Press, Taylor & Francis Group, (2018).
    ISBN-13: 978-1138486294
    ISBN-10: 1138486299
  • X. L. Chen and Y. J. Liu, “Finite Element Modeling and Simulation with ANSYS Workbench”, 1st ed. Boca Raton, Florida: CRC Press, Taylor & Francis Group, (2014).
    ISBN-13: 978-1439873847
    ISBN-10: 1439873844

Referred Journal Articles

  1. M. Hashem, A. Aghilinejad, X. L. Chen, H. Tan, “Compound droplet modeling for circulating tumor cell
    microfiltration with adaptive meshing refinement”, Journal of Fluids Engineering, 142(11), (2020).
  2. K. Ahasan, C. Landry, X. L. Chen, J. H. Kim, “Effect of angle-of-attacks on deterministic lateral
    displacement (DLD) with symmetric airfoil pillars”, Biomedical Microdevices, 22(42), (2020).
  3. P. Chang, C. Landry, X. L. Chen, H. Tan, “Compound droplet dynamics of a tumor cell squeezing through
    conical microfilters”, Theoretical and Computational Fluid Dynamics, 34, 287–300 (2020).
  4. A. Aghilinejad, M. Aghaamoo and X. L. Chen, “On the transport of particles/cells in high-throughput
    deterministic lateral displacement devices: Implications for circulating tumor cell separation”,
    Biomicrofluidics, 13(3), DOI: 10.1063/1.5092718 (2019).
  5. M. Aghaamoo, A. Aghilinejad, X. L. Chen and J. Xu, “On the design of deterministic dielectrophoresis
    for continuous separation of circulating tumor cells from peripheral blood cells”, Electrophoresis, 40(10):
    1486-1493, DOI: 10.1002/elps.201800459 (2019).
  6. B. Dincau, A. Aghilinejad, X. L. Chen and J-H. Kim, “Vortex-free high-Reynolds deterministic
    lateral displacement (DLD) via airfoil pillars”, Microfluidics and Nanofluidics, 22:137, DOI:
    10.1007/s10404-018-2160-3 (2018).
  7. X. L. Zhang, M. A. Hashem, X. L. Chen and H. Tan, “On passing a non-Newtonian Circulating
    Tumor Cell (CTC) through a deformation-based microfluidic chip”, Theoretical and Computational Fluid
    Dynamics, DOI: 10.1007/s00162-018-0475-z (2018).
  8. B. Dincau, A. Aghilinejad, T. Hammersley, X. L. Chen and J-H. Kim, “Deterministic lateral
    displacement (DLD) in the high Reynolds number regime: high-throughput and dynamic separation
    characteristics”, Microfluidics and Nanofluidics, 22:59, DOI: 10.1007/s10404-018-2078-9 (2018).
  9. A. Aghilinejad, M. Aghaamoo, X. L. Chen and J. Xu, “Effects of electrothermal vortices on insulatorbased dielectrophoresis for circulating tumor cell separation”, Electrophoresis, DOI:10.1002/elps.201700264
    (2017).
  10. X. Zhang, X. L. Chen and H. Tan, “On the thin-film-dominated cell passing pressure of cancer cell
    squeezing through a microfluidic CTC chip”, Microfluidics and Nanofluidics, 21:146, DOI:10.1007/s10404-
    017-1986-4 (2017).
  11. Z. Zhang, C. Drapaca, X. L. Chen and J. Xu, “Droplet squeezing through a narrow constriction:
    minimum impulse and critical velocity”, Physics of Fluids, 29 (7), 072102 (2017).
  12. D. Binion and X. L. Chen, “A krylov enhanced proper orthogonal decomposition method for
    frequency domain model reduction”, Engineering Computations, 34(2), 285-306 (2017).
  13. F. Yang, Q. Xie, X. Zhang and X. L. Chen, “Characterization and Optimization of an Electro-thermal
    Microactuator for Precise Track Positioning”, Computer-aided Design and Applications, 14 (6), 815-822
    (2017).
  14. B. Wang and X. L. Chen, “Fast multipole accelerated dual reciprocity boundary element method for diffusion problems”, Annals of Solid and Structural Mechanics, 7 (1), 45-58 (2015).
  15. M. Aghaamoo, Z. Zhang, X. L. Chen and J. Xu, “Deformability-based circulating tumor cell separation with conical-shaped microfilters: concept, optimization and design criteria”, Biomicrofluidics, 9, 034106 (2015).
  16. Z. Zhang, X. L. Chen, and J. Xu, “Entry effects of droplet in a micro confinement: implications for deformation-based circulating tumor cell microfiltration”, Biomicrofluidics, 9, 024108 (2015).
  17. Z. Zhang, J. Xu, B. Hong and X. L. Chen, “The effects of 3D channel geometry on CTC passing pressure- towards deformability-based cancer cell separation”, Lab on a Chip, 14, 2576-2584 (2014).
  18. Y. Xu, A. Hashmi, G. Yu, X. Lu, H. Kwon, X. Chen, J. Xu, “Microbubble array for on-chip worm processing”, Applied Physics Letters, 102, 023702 (2013).
  19. G. Yu, X. Chen and J. Xu, “Acoustophoresis in variously shaped liquid droplets”, Soft Matter, 7, 10063- 10069 (2011).
  20. D. Binion and X. L. Chen, “A Krylov enhanced proper orthogonal decomposition method for efficient nonlinear model reduction”, Finite Elements in Analysis and Design, 47, No. 7, 728-738, (2011).
  21. D. Binion and X. L. Chen, “Coupled electro-thermal-mechanical analysis for MEMS via model order reduction”, Finite Elements in Analysis and Design, to appear, (2010).
  22. X. L. Chen, H. Zhang and M. Wu, “Modeling brain electrical activity by an image-based boundary element method”,Engineering Analysis with Boundary Elements, 34, 995–1002 (2010).
  23. D. Kim, X. L. Chen and P. Allen, “Micro-electro discharge drilling characteristics on Molybdenum aperture fabrication”,International Journal of Machining and Machinability of Materials, 7, No. 3-4, 161-175 (2010).
  24. X. Zhao, X. L. Chen and L. Lu, “Pointwise identification of elastic properties in nonlinear hyperelastic membranes. Part II: experimental validation”, ASME Journal of Applied Mechanics, 76, No. 6, 061014-8 (2009).
  25. X. L. Chen, W. Cui and W. Xue, “Process modeling and device-package simulation for optimization of MEMS gyroscopes”,Computer-aided Design and Applications, 6, No. 3, 375-386 (2009).
  26. X. L. Chen and H. Zhang, “An integrated imaging and BEM for fast simulation of freeform objects”, Computer-aided Design and Applications, 5, No.1-4, 371-380 (2008).
  27. P. Allen and X. L. Chen, “Process simulation of micro electro-discharge machining on molybdenum”, Journal of Materials Processing Technology, 186, No. 1-3, 346-355 (2007).
  28. X. L. Chen, “Comparison of numerical methods for noise source identification”, Noise Control Engineering Journal, 54, No. 6, 420-428 (2006).
  29. X. L. Chen and Y. J. Liu, “An advanced 3-D boundary element method for characterizations of composite materials,” Engineering Analysis with Boundary Elements, 29, No. 6, 513-523 (2005).
  30. Y. J. Liu, N. Nishimura, Y. Otani, T. Takahashi, X. L. Chen and H. Munakata, “A fast boundary element method for the analysis of fiber-reinforced composites based on a rigid-inclusion model,” ASME Journal of Applied Mechanics, 72, No. 1, 115-128 (2005).
  31. Y. J. Liu and X. L. Chen, “Modeling of carbon nanotube-based composites by the boundary element method,” JASCOME Reviews, No. 2004-1, 45-57 (2004).
  32. X. L. Chen and Y. J. Liu, “Square representative volume elements for evaluating the effective material properties of carbon nanotube-based composites,” Computational Materials Science, 29, No. 1, 1-11(2004).
  33. Y. J. Liu and X. L. Chen, “Evaluations of the effective material properties of carbon nanotube-based composites using a nanoscale representative volume element,” Mechanics of Materials, 35, No. 1-2, 69-81 (2003).
  34. Y. J. Liu and X. L. Chen, “Continuum models of carbon nanotube-based composites using the boundary element method,” Electronic Journal of Boundary Elements, 1, No. 2, 316-335 (2003).
  35. X. L. Chen and Y. J. Liu, “Thermal stress analysis of multi-layer thin films and coatings by an advanced boundary element method,” CMES: Computer Modeling in Engineering & Sciences, 2, No. 3, 337-349 (2001).
  36. X. L. Chen and Y. J. Liu, “Multiple-cell modeling of fiber-reinforced composites with the presence of interphases using the boundary element method,” Computational Materials Science, 21, No. 1, 86-94 (2001).

Referred Conference Papers

  1. Khan, X. L. Chen, J. Xu, “Separation of Nonviable Chinese Hamster Ovary (Cho) Cells Using Dielectrophoresis in a Deterministic Lateral Displacement Ratchet”, in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2020).
  2. Rahmati, X. L. Chen, “On the Design of a DLD-DEP Device for Separation of Circulating Tumor Cells in Blood”, in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2020).
  3. Gioe, X. L. Chen, J. H. Kim, “Towards deep learning approaches for quantitative analysis of high-throughput DLD”, in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2020).
  4. Aghilinejad, C. Landry, G. Cha and X. L. Chen, “Enhancing the cell viability in high throughput deterministic lateral displacement separation of circulating tumor cells”, in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2019).
  5. Chang, M. Hashem, X. L. Chen and H. Tan, “Dynamics of compound droplet passing through a conical CTC microfilter”, in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2019).
  6. Aghilinejad, M. Aghaamoo and X. L. Chen, “Numerical study of Joule heating effect on dielectrophoresis-based circulating tumor cell separation”, in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2017).
  7. Dincau, A. Aghilinejad, X. L. Chen and J-H. Kim, “Characterizing the turbulent regime for deterministic laterial displacement (DLD) devices”, in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2017).
  8. Aghaamoo, A. Aghilinejad and X. L. Chen, “Numerical study of insulator-based dielectrophoresis method for circulating tumor cell separation”, Proceedings of SPIE, Microfluidics, BioMEMS, and Medical Microsystems XV, 100611A (2017).
  9. Zhang, X. L. Chen and H. Tan, “A numerical study on highly viscous compound cancer cell microfiltration”, in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2016).
  10. Zhang, X. Zhao, J. Xu and X. L. Chen, “The critical velocity with minimum momentum change in pushing a droplet through a constriction channel”, in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2016).
  11. Aghaamoo, J. Xu and X. L. Chen, “A computational study on non-uniform cross-sectional deformability-based CTC separation devices”, in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2015) [ASME IMECE Track 3-Biomedical and Biotechnology Engineering 2nd place Student Paper Competition Award].
  12. Zhang, J. Xu and X. L. Chen, “Compound droplet modelling of Circulating Tumor Cell (CTC) microfiltration”, in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2015).
  13. Z. Zhang, J. Xu and X. L. Chen, “Modeling cell deformability in CTC microfluidic filters”, in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2014).
  14. Z. Zhang, J. Xu and X. L. Chen, “Predictive model for the cell passing pressure in deformation-based CTC chips”, in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2014).
  15. Z. Fang, Z. Zhang, X.L. Chen and J. Xu, “Inertial microfluidic spiral CTCs filter with micropillars”, in: Proceedings of IEEE EMBS Special Topics Conference on Healthcare Innovation & Point-of-Care Technologies (HIC-POCT) (2014).
  16. Q. Xie and X.L. Chen, “Response surface based optimization of an electro-thermal microactuator for high track density optical disk drives”, in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2013).
  17. B. Wang and X. L. Chen, “Steady-state analysis for oxygen diffusion in infarcted myocardial tissue”, in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2012).
  18. F. Yang, N. Lei, X. L. Chen and J. P. Yang, “Modeling and optimization of an in-plane rotary microactuator with thermal unimorph”, in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2012).
  19. G. Yu, A. Hashmi, Y. Xu, H.-J. Kwon, X. Chen and J. Xu, “Microbubble array as a versatile tool for on- chip worm processing”, in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2012).
  20. G. Yu, N. Lei, X. Chen, W. Xue and J. Xu, “Free-surface microfluidics: exploring new actuation and sensing methods”, in: Nanotech Proceedings (2012).
  21. G. Yu, A. Hashmi, X. Chen, and J. Xu, “Microfluidic manipulation of Caenorhabditis elegans using acoustic radiation forces”, in: Nanotech Proceedings (2012).
  22. X. L. Chen, F. Yang and J. P. Yang, “Design optimization of a micromirror actuator for high track density optical disk drives”, in: Proceedings of ASME Information Storage & Processing Systems Conference (2011).
  23. G. Yu, X. L. Chen and J. Xu, “Acoustic manipulation of particles in variously shaped liquid droplets”, in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2011).
  24. W. Cui, X. L. Chen and W. Xue, “Robust compensator control of a non-resonant MEMS gyroscope with linear quadratic regulator”, to appear in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2010).
  25. D. Binion and X. L. Chen, “Prestressed harmonic simulation of electrostatic microresonator with proper orthogonal decomposition”, to appear in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2010).
  26. D. Binion and X. L. Chen, “Modeling electrostatic actuator pull in behavior with proper orthogonal decomposition”, in:Proceedings of ASME International Design Engineering Technical Conferences & Computers and Information in Engineering Conference (2010).
  27. W. Cui, W. Xue and X. L. Chen, “Compensator design for a MEMS gyroscope with quadratic optimal control”, in:Proceedings of ASME International Design Engineering Technical Conferences & Computers and Information in Engineering Conference (2010).
  28. D. Binion and X. L. Chen, “Fast harmonic MEMS simulation with Arnoldi model order reduction”, in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2009).
  29. W. Cui, X. L. Chen and W. Xue, “Design optimization for non-resonant micromachined MEMS gyroscopes”, in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2009).
  30. M. Wu and X. L. Chen, “Tikhonov regularization methods for the inverse scalp electroencephalography”, in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2009).
  31. X. L. Chen and D. Kim, “Implementing the design and manufacturing track in a mechanical engineering program”, in: Proceedings of American Society for Engineering Education Conference & Exhibition (2009).
  32. H. Gurocak, X. L. Chen, A. Jokar and D. Kim, “Assessment of program outcomes for ABET accreditation”, in: Proceedings of American Society for Engineering Education Conference & Exhibition (2009).
  33. X. L. Chen, H. Zhang and W. Miller, “Automatic feature recognition for data interoperability issues in high-speed electronics system design”, in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2008).
  34. X. L. Chen, “Longitudinal integration of problem-based learning into undergraduate mechanical engineering courses”, in:Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2008).
  35. D. Binion and X. L. Chen, “Fast multiphysics MEMS simulation with Arnoldi model order reduction”, in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition (2008).
  36. A. Jokar, H. Gurocak, D. Kim, X. L. Chen and H. Rad, “Multi-dimensional and interactive model for introduction to mechanical engineering,” in: Proceedings of American Society for Engineering Education Conference & Exhibition (2007).
  37. P. Allen, X. L. Chen and D. Kim, “Numerical and experimental study on micro-electrical discharge micromachining characteristics on Molybdenum,” in: Proceedings of ASME International Mechanical Engineering Congress & Exhibition(2005).
  38. X. L. Chen, D. Kim and H. Gurocak, “Outreach program with summer camps and manufacturing engineering workshops,”in: Proceedings of American Society for Engineering Education Conference & Exhibition (2005).
  39. X. L. Chen and Y. J. Liu, “Modeling of advanced composite materials by the boundary element method”, in: Computational Engineering I. Advances in Continuum Mechanics and Electromagnetics (ICOME Sapporo, Japan), edited by T. Honma, M. Tanaka, H. Igarashi and T. Matsumoto, JASCOME, p.13-20 (2004).
  40. Y. J. Liu and X. L. Chen, “Analysis of carbon nanotube-based composites by an advanced boundary element method,”  in:Proceedings of the Third International Conference on Boundary Element Techniques (BETeq, Beijing), edited by Zhenhan Yao and M. H. Aliabadi, Tsinghua University Press, p. 329-334 (2002).
  41. Y. J. Liu, N. Xu and X. L. Chen, “Development of the boundary element method for the analysis of thin and layered structures,”  in: Advances in Computational Engineering & Sciences (ICES, Los Angeles), edited by S. N. Atluri and R. W. Brust, Tech Science Press, p. 51-56. (2000).
  42. X. L. Chen, H. X. Hua and Y. J. Liu, “A higher-order FEM for vibration control of composite plates with distributed piezoelectric sensors and actuators,”  in: Advances in Computational Engineering & Sciences (ICES, Los Angeles), edited by S. N. Atluri and R. W. Brust,  Tech Science Press, p.1506-1511, (2000).
  43. X. L. Chen, H. X. Hua and H. Sol, “Composite plate stiffness identification using neural networks,” in: Proceedings of the 6th International Modal Conference, Canada, (1998). 

Conference Presentations with Abstracts

  1. Landry, X. L. Chen and Z. Zhang, “A linear behavior between squeezing pressure and advancing length: viscous droplet squeezing into circular confinement at Ca =3/4”, 72nd Annual Meeting of the APS Division of Fluid Dynamics, Seattle, WA, November 23-26, (2019).
  2. Z. Zhang, J. Xu and X. L. Chen, “CFD design of deformation-based cancer cell micro filtration”, ASME International Mechanical Engineering Congress & Exhibition, Montreal, Canada, November 14-20, (2014).
  3. Z. Zhang, J. Xu and X. L. Chen, “Flow regime and dynamic critical pressure of droplet entering confined microchannel”, The 67th Annual Meeting of the American Physical Society Division of Fluid Dynamics, San Francisco, CA, November 23-25, (2014).
  4. G. Yu, Y, Xu, X. Chen and J. Xu, “Ultrasonic manipulation in free-surface microfluidics”, in: Proceedings of the 3rd International Conference on Advances in Microfluidics & Nanofluidics (2012).
  5.  X. L. Chen, H. Zhang and M. Wu, “Inverse boundary element analysis for biopotential reconstruction with realistic head models”, The 10th US National Congress on Computational Mechanics, Columbus, OH, June 16-19, (2009).
  6. X. L. Chen and H. Zhang, “Integrated imaging and fast boundary element computation for complex freeform objects”, The 8th World Congress on Computational Mechanics, Venice, Italy, June 30-July 4, (2008).
  7. X. L. Chen and Y. J. Liu, “Modeling and Characterization of Nanocomposites by the Boundary Element Method”, (Invited) In symposium: Multiscale Modeling and Simulations of Nanocomposites, The 9th US National Congress on Computational Mechanics, San Francisco, CA, July 23-26, (2007).
  8. X. L. Chen, Y. J. Liu and N. Nishimura, “An Image-based Fast Boundary Element Computation”, The 9th US National Congress on Computational Mechanics, San Francisco, CA, July 23-26, (2007).
  9. X. L. Chen, “Modeling biomaterials using an integrated imaging and computation approach”, The 7th World Congress on Computational Mechanics, Los Angeles, LA, July 16-22, (2006).
  10. X. L. Chen, Y.J. Liu and N.S. Nishimura, “A boundary element approach for modeling and characterization of scaffold materials”, The 8th US National Congress on Computational Mechanics, Austin, Texas, July 25-27, (2005).
  11. X. L. Chen and Y.J. Liu, “Modeling and characterization of composite materials by the boundary element method”, The 8thUS National Congress on Computational Mechanics, Austin, Texas, July 25-27, (2005).
  12. Y. J. Liu and X. L. Chen, “Evaluations of the effective material properties of carbon nanotube-based composites by the finite element and boundary element methods,”  (Invited) In symposium: Modeling and Characterization of Nanocomposites,ASME International Mechanical Engineering Congress and Exhibition, New Orleans, Louisiana, November 17-22, (2002).
  13. Y. J. Liu and X. L. Chen, “Analysis of carbon-nanotube based composites by the boundary element method,”  (Invited) In symposium: Advances in Boundary Element Methods, ASME International Mechanical Engineering Congress and Exhibition, New Orleans, Louisiana, November 17-22, (2002).
  14. X. L. Chen and Y. J. Liu,  “On the use of the boundary element method for the analysis of fiber-reinforced composites and thin films,” The 6th US National Congress on Computational Mechanics, Dearborn, Michigan, August 1-3, (2001).
  15. Y. J. Liu, H. Fan and X. L. Chen, “A boundary element method for analyzing thin piezoelectric solids with applications to MEMS devices,” The 6th US National Congress on Computational Mechanics, Dearborn, Michigan, August 1-3, (2001).