Profiling nascent transcription in the immune cells found in our blood throughout acute COVID-19 infection not only revealed key regulatory networks underlying disease progression and thus prognosis of disease outcome, but also that the same transcription factor can have a distinct impact on disease outcome in different immune cell types. Based on these data, it may be possible to prognose an unintervened disease outcome early during infection. Read Michael’s paper now published in Cell Reports Medicine at this link: https://doi.org/10.1016/j.xcrm.2023.100935.