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Micro-Nano-Bio Systems Lab Research

Research

Printed flexible hybrid electronics for health monitoring and human-machine interface

This project leverages screen/inkjet-printing technologies with various electronic ink materials to fabricate a printed, electronic platform that offers high mechanical stretchability and the ability to form a conformal interface with the human skin. (Collaboration with Dr. Yeo at Georgia Tech)

  • H.-R. Lim†, S.M. Lee†, S. Park†, C. Choi, H. Kim, M. Mahmood, Y. Lee, J.-H. Kim*, and W.-H. Yeo*, “Smart Bioelectronic Pacifier for Real-Time Continous Monitoring of Salivary Electrolytes“, submitted to Biosensors and Bioelectronics, 2022
  • S. Ban, Y. J. Lee, S. Kwon, Y.S. Kim, J.-H Kim*, and W.-H Yeo, “Wireless Persistent Human-Machine Interfaces via Soft Headband Bioelectronics and Electrooculography”, submitted to Advanced Science
  • S. Ban, Y. J. Lee, J. W. Chang, J.-H. Kim, and W.-H. Yeo, “Human-Machine Interface Based on Gaze and Eye direction tracking for the Robot arm“, in preparation
  • S. Park, S. Ban, A. Bunn, S. Kwon, H. Lim, W-.H. Yeo, and J-.H Kim*, “Fully screen-printed, PI/PEG blends enabled patternable electrodes for scalable manufacturing of skin-conformal, stretchable, wearable electronics“, submitted to ACS Applied Materials and Interfaces
  • S. Park C.H. Ha, J.-H. Kim, and H.R. Lim, “Non-invasive Monitoring of Metabolites, Hormones, and Electrolytes in Wearable Flexible Chemical Sensors“, in preparation

Microfluidic device for particle separation with Airfoil shaped pillars

Deterministic Lateral Displacement (DLD) for nanoparticle separation: DLD is a continuous microfluidic separation device that uses a repeating array of pillars to selectively displace particles having a mean diameter greater than the critical diameter. The critical diameter is an emergent property influenced by pillar shape, size, and spacing in addition to the suspending fluid and target particle properties. This project will design and fabricate microfluidic devices for DLD demonstration using conventional soft lithography technique. (Supported by WSU New Faculty Seed grant-131078, Collaboration with Analog Devices, Inc.)

  • E. Gioe, J.-H. Kim, and X. Chen, “Deterministic Lateral Displacement (DLD) Analysis Tool Utilizing Machine Learning Towards High-Throughput Separation“, Micromachines, 2022. 13(5), 661
  • B. Senf and J.-H. Kim, “Effect of Viscosity on High Throughput Deterministic Lateral Displacement (DLD)“, Micro 2022, 2(1), 100-112
  • K. Ahasan, C. M. Landry, X. Chen, and J.-H. Kim*, “Effect of Angle-of-Attacks on Deterministic Lateral Displacement (DLD) with Symmetric Airfoil Pillars“, Biomedical Microdevices, (2020) 22: 42
  • B. M. Dincau,  A. Aghilinejad, X. Chen, SY Moon, and J.-H. Kim*, “Vortex-free high-Reynolds deterministic lateral displacement (DLD) via airfoil pillars“, Microfluidics and Nanofluidics,  2018, 22, 137.
  • B. M. Dincau,  A. Aghilinejad, T. Hammersley,  X. Chen, and J.-H. Kim*, “Deterministic lateral displacement (DLD) in the high Reynolds number regime-high throughput and dynamic separation characteristics”, Microfluidics and Nanofluidics, 2018, 22 (6), 59
  • B. Dincau, A. Aghilinejad, X. Chen, and J.-H. Kim, “Characterizing the turbulent regime for deterministic lateral displacement (DLD) devices”, ASME IMECE 2017-71892, November 3-9, 2017.

Novel printing technology with nano-ink

Novel printing technology with nanoink for biosensor fabrication: Develop a novel non-contact printing method for nanomaterials and biomolecules using capillary nanoink bridge. (Supported by DoD CDMRP W81XWH-17-1-0083)

  • S.-J. Kahng, S. D. Soelberg, F. Fondjo, J.-H. Kim, C. E. Furlong, and J.-H. Chung, “Carbon Nanotube-Based Thin-Film Resistive Sensor for Point-Of-Care Screening of Tuberculosis“, Biomedical Microdevices, (2020) 22:50
  • S.-J. Kahng, C. Cerwyn, B. M. Dincau, J.-H. Kim, I. V. Novosselov, M. P. Anantram, and J.-H. Chung, “Nanoink Bridge-induced Capillary Pen Printing for Chemical and Biological Sensors”, Nanotechnology, 2018, 29, 335304

Micro/nanoneedle fabrication for biomedical applications

Design and develop micro/nanostructured needle fabrication for biomedical application. (Supported by WSU Vancouver mini grant and Probus Med Tech Inc.)

  • B. M. Dincau, Y. Lee, J.-H. Kim* and W.-H. Yeo,  “Recent advances in nanoparticle concentration and viral detection by using biosensors and bioelectronics”, Sensors 2017, 17(10), 2316
  • S.J. Kahng, H.-B. Lee, J.-H. Chung, and J.-H. Kim*, “Nanostructured Tip-Shaped Biosensors: Application of Six Sigma Approach for Enhanced Manufacturing”, Sensors 2017, 17(1), 17 (invited paper)
  • D. Saadat-Moghaddam and J.-H. Kim*, “A Microneedle Functionalized with Polyethyleneimine and Nanotubes for Highly Sensitive, Label-Free Quantification of DNA”, Sensors, 2017, 17(8), 1883
  • S.J. Kahng, H.-B. Lee, J.-H. Chung, and J.-H. Kim*, “Dendritic nanotip: Controlled fabrication and amplification-free detection of DNA”, Sensors (invited paper), 2016

Study of flow-boiling morphological characteristics with surface wettability gradient in microchannel flow

In this study, we investigate two-dimensional flow-boiling morphological characteristics with hydrophilic coating on a hot-spot. (Supported by NSF CBET-1707056 and Undergraduate Summer Research program)

  • A. Karim, Y. J. Kim and J.-H. Kim*, “Two-dimensional flow boiling characteristics with wettability surface in microgap heat sink and heat transfer prediction using Artificial Neural Network“, J. Heat Transfer, 202, 143(9): 091601
  • Y. Hayashi, N. Saneie, G. Yip, Y. Kim*, and J.-H. Kim, “Metallic Nanoemulsion with Galinstan for High Heat-Flux Thermal Management”, Int. J. Heat Mass Transf, 2016, 101, 1204-1216

Soft nanocomposite for wearable electronics

Synthesis of soft nanocomposite for flexible, wearable bioelectronics: Develop a flexible, wearable bioelectronic system using an elastomeric hybrid nanocomposite, composed of zero-dimensional carbon nanoparticles and one-dimensional carbon nanotubes. A fast and facile fabrication route is used to construct a unique architecture by microscale replica molding process using an ultra-soft elastomeric membrane in conjunction with the nanomaterials. (Supported by Undergraduate Summer Research program and New Faculty Startup)

  • R. Herbert, H.-R. Lim, S. Park, J.-H. Kim, and W.-H. Yeo, “Recent Advances in Printing Technologies of Nanomaterials for Implantable Wireless Systems in Health Monitoring and Diagnosis“, Adv. Healthcare Mater. 2021, 2100158
  • Kim, Y.-T. Kwon, H.-R. Lim, J.-H. Kim, Y.-S. Kim, and W.-H. Yeo, “Recent Advances in Wearable Sensors and Integrated Functional Devices for Virtual and Augmented Reality Applications”, Adv. Funct. Mater., 2020, 2005692
  • R. Herbert, J.-H. Kim, Y.-S. Kim, H. M. Lee, and W.-H. Yeo, “Soft Material-Enabled, Flexible Hybrid Electronics for Medicine, Healthcare, and Human-Machine Interfaces“, Materials, 2018, 11, 187
  • F. Fondjo and J.-H. Kim, “Hybrid nanocomposite membrane for wearable electronics”, ASME IMECE 2017- , November 3-9, 2017.
  • F. Fondjo, M Teller, C. Howe, W.-H. Yeo, and J.-H. Kim, “Synthesis of a Soft Nanocomposite for Flexible, Wearable Bioelectronics”, IEEE Electronic Components and Technology Conference 2017, May 30 – June 2, 2017, Orlando, FL.

Development of Point-of-Care diagnosis for low-resource settings

  • T. Li, S.D. Soelberg, Z. Taylor, V. Sakthivelpathi, C.E. Furlong, J.-H. Kim, S. Ahn, P.D. Han, L.M. Starita, J. Zhu, and J.-H. Chung, “Highly Sensitive Immunoresistive Sensor for Point-of-Care Screening for COVID-19“, Biosensors, 2022, 12(3), 149
  • B. Senf, W.-H. Yeo, and J.-H. Kim*, “Recent Advances in Portable Biosensors for Biomarker Detection in Body Fluids“, Biosensors 2020, 10, 127
  • G. Fotouhi, A. Cairns, J.-H. Kim, K. Olson, K.-H. Lee, and J.-H. Chung, “Study of heat-cured polyethyleneimine coated on a microtip for qPCR analysis”, in preparation, 2016
  • S. Inoue, H.-B. Lee, A. L. Becker, K. M. Weigel, J.-H. Kim, K.-H. Lee, G. A. Cangelosi, and J.-H. Chung, “Dielectrophoretic characterization of antibiotic-treated Mycobacterium tuberculosis complex cells”, Analytical Bioanalytical Chemistry, 407(25) 7673-7680, 2015
  • M. Hiraiwa, J.-H. Kim*, H.-B. Lee, S. Inoue, A. L. Becker, K. Weigel, G. A. Cangelosi, K.-H. Lee, and J.-H. Chung, “Amperometric immunosensor for rapid detection of Mycobacterium tuberculosis”, Journal of Micromechanics and Microengineering. 25 055013, 2015

Biomolecule (DNA, proteins, bacteria, and viruses) manipulation for single molecule analysis

A wafer-scale nanofluidic system that incorporates an array of accessible open nanochannels and nano-microtrappers to enrich and elongate target molecules (DNA) via the combination of an electric field and hydrodynamic force. (Supported by New Faculty Startup)

  • Y.-S. Kim, B. M. Dincau, Y.-T. Kwon, W.-H. Yeo, and J.-H. Kim*, “Directly Accessible and Transferrable Nanofluidic Systems for Biomolecule Manipulation”, ACS Sensors, 2019, Under review