Nomenclature Guidelines
Nomenclature Guidelines
UGT genes
New UGT genes are named according to the HUGO Gene Nomenclature Guidelines as currently recommended in this paper:
…which updated the process described here…
…and before that described here…
UGT families are grouped by Kingdom with reserved number ranges as follows:
Additional Information
UGT families are grouped by Kingdom with reserved number ranges as follows:Kingdom | Reserved Number Ranges | |
---|---|---|
Animals | UGTs 1 - 50 | and 201 - 500; 2001 - 5000; etc |
Fungi/Yeast | UGTs 51 - 70 | and 501 - 700; 5001 - 7000; etc |
Plants | UGTs 71 - 100 | and 701 - 1000; 7001 - 10000; etc |
Bacteria | UGTs 101 - 200 | and 1001 - 2000; 10001 - 20000; etc |
- UGT families (indicated by first number) show ~45% or greater amino acid sequence identity
- UGT sub-families (indicated by letter/s following family number) show ~60% or greater amino acid sequence identity
- Do not use letters “I” or “O” for subfamily since they can be confused with numbers “1” and “o”.
- UGT genes (indicated by number following subfamily letter) show ~100% identity
- Slightly less than 100% identity may be found for allelic variants (same gene).
Note: These family and subfamily percent identity cut-offs are only considered guidelines. Adherence to these limits tends to change over time often in an attempt to cluster similar families and subfamilies as the numbers of available sequences in each group has grown.
Human UGT Alleles
Human UGT alleles are named by a subcommittee of the UGT nomenclature committee chaired by Dr. Chantal Guillemette. Specific information regarding human UGT allele nomenclature can be found at the Laval University website.
Please contact Dr. Guillemette for more information on naming new human UGT alleles.