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John Clarke Lab Xenobiotic Exposures and Toxicities

Scientific mission

Toxicities from xenobiotic exposures are a significant burden on human health. These exposures occur both intentionally (drugs and dietary supplements) and unintentionally (environmental contamination and naturally occurring toxins). Our focus is on the metabolism and disposition of xenobiotics as key determinants of toxicity, and our goal is to provide quantifiable endpoints that can be used to identify at-risk populations.

Sources of xenobiotic exposures

Dietary Supplements
Environmental Contamination
Natural Sources










Satellite image of Lake Erie blue-green algal bloom (2011)