Germline Developmental and Stem Cell Biology

Our Research

A growing body of research indicates that the manifestation of many adult diseases can be traced back to disruptions during fetal and neonatal development. Recent studies indicate that instances of infertility, which impacts approximately 1 in 6 of couples, may have developmental origins. Furthermore, the underlying etiology for many cases of male-factor infertility remains unknown. Therefore, our laboratory studies the critical transitions during development that set the stage for male sperm production into adulthood. Our goal is to better understand male germline development from a basic science standpoint to ultimately identify the critical factors and pathways that influence male fertility long into adulthood. In addition, as the production of sperm in men is supported by a population of stem cells, we use germline development as a model to better understand the molecular processes underlying stem cell formation across various cell lineages.