Fibroblast Heterogeneity and Skin Regeneration
Cultured Embryonic Day 30 Porcine Fibroblasts
When skin is wounded a scar is formed, which isn’t typically a problem if it is small. However, individuals with deep wounds covering larger portions of their body would be greatly affected and significantly benefit if their skin fully regenerated. The goal of our laboratory is to generate a full understanding to transform skin to fully regenerate, instead of producing a scar when wounded.
We have recently discovered that by controlling the nature of a specialize cell called ‘fibroblasts’, we can influence the regenerative potential of skin (Phan et al. 2020 eLife, Driskell et al. 2013 – Nature).
We have also generated a searchable web resource so that researchers can simply query and investigate our large databases of scarring and regenerative tissues (https://skinregeneration.org/)