Ryan Driskell, Ph.D.

Publications

• Philippeos C, Telerman SB, Oulès B, Pisco AO, Shaw TJ, Elgueta R, Lombardi G, Driskell RR, Soldin M, Lynch MD, Watt FM. Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations. The Journal of Investigative Dermatology. 2018;138(4):811-825. doi:10.1016/j.jid.2018.01.016.
• Salz L, Driskell RR. Horizontal Whole Mount: A Novel Processing and Imaging Protocol for Thick, Three-dimensional Tissue Cross-sections of Skin. Journal of Visualized Experiments : JoVE. 2017;(126):56106. doi:10.3791/56106.
• Telerman SB, Rognoni E, Sequeira I, Pisco AO, Lichtenberger BM, Culley OJ, Viswanathan P, Driskell RR, Watt FM. Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and Growth. The Journal of Investigative Dermatology. 2017;137(11):2270-2281. doi:10.1016/j.jid.2017.06.015.
• Salz L, Driskell RR. The Sox2: GFP+/- knock-in mouse model does not faithfully recapitulate Sox2 expression in skin. Experimental Dermatology. 2017;26(11):1146-1148. doi:10.1111/exd.13396.
• Kaushal G, Rognoni E, Lichtenberger BM, Driskell RR, Kretzschmar K, Hoste E, Watt FM. Reply to Chi et al. The Journal of Investigative Dermatology. 2017;137(1):247-248. doi:10.1016/j.jid.2016.08.026.
• Rognoni E, Gomez C, Pisco AO, Rawlins EL, Simons BD, Watt FM, Driskell RR. Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing. Development (Cambridge, England). 2016;143(14):2522-2535. doi:10.1242/dev.131797.
• Mastrogiannaki M, Lichtenberger BM, Reimer A, Collins CA, Driskell RR, Watt FM. β-Catenin Stabilization in Skin Fibroblasts Causes Fibrotic Lesions by Preventing Adipocyte Differentiation of the Reticular Dermis. The Journal of Investigative Dermatology. 2016;136(6):1130-1142. doi:10.1016/j.jid.2016.01.036.
• Kretzschmar K, Weber C, Driskell RR, Calonje E, Watt FM. Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity. Cell Reports. 2016;14(2):269-281. doi:10.1016/j.celrep.2015.12.041.
• Kaushal GS, Rognoni E, Lichtenberger BM, Driskell RR, Kretzschmar K, Hoste E, Watt FM. Fate of Prominin-1 Expressing Dermal Papilla Cells during Homeostasis, Wound Healing and Wnt Activation. The Journal of Investigative Dermatology. 2015;135(12):2926-2934. doi:10.1038/jid.2015.319.
• Driskell RR, Watt FM. Understanding fibroblast heterogeneity in the skin. Trends in Cell Biology. 2015;25(2):92-99. doi:10.1016/j.tcb.2014.10.001.
• Driskell RR, Jahoda CA, Chuong CM, Watt FM, Horsley V. Defining dermal adipose tissue. Experimental dermatology. 2014;23(9):629-631. doi:10.1111/exd.12450.
• Driskell RR, Lichtenberger BM, Hoste E, Kretzschmar K, Simons BD, Charalambous M, Ferron SR, Herault Y, Pavlovic G, Ferguson-Smith AC, Watt FM. Distinct fibroblast lineages determine dermal architecture in skin development and repair. Nature. 2013;504(7479):277-281. doi:10.1038/nature12783.
• Lesko MH, Driskell RR, Kretzschmar K, Goldie SJ, Watt FM. Sox2 modulates the function of two distinct cell lineages in mouse skin. Developmental Biology. 2013;382(1):15-26. doi:10.1016/j.ydbio.2013.08.004.
• Driskell RR, Juneja VR, Connelly JT, Kretzschmar K, Tan DW, Watt FM. Clonal growth of dermal papilla cells in hydrogels reveals intrinsic differences between Sox2-positive and –negative cells in vitro and in vivo. The Journal of investigative dermatology. 2012;132(4):1084-1093. doi:10.1038/jid.2011.428.
• Driskell RR, Clavel C, Rendl M, Watt FM. Hair follicle dermal papilla cells at a glance. Journal of Cell Science. 2011;124(8):1179-1182. doi:10.1242/jcs.082446.
• Jensen KB, Driskell RR, Watt FM. Assaying proliferation and differentiation capacity of stme cells using disaggregated adult mouse epidermis. Nature Protocols. 2010;5(5):898-911. doi:10.1038/nprot.2010.39.
• Watt FM, Driskell RR. The therapeutic potential of stem cells. Philosophical Transactions of the Royal Society B: Biological Sciences. 2010;365(1537):155-163. doi:10.1098/rstb.2009.0149.
• Driskell RR, Giangreco A, Jensen KB, Mulder KW, Watt FM. Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis. Development (Cambridge, England). 2009;136(16):2815-2823. doi:10.1242/dev.038620.
• Driskell RR, Goodheart M, Neff T, Liu X, Luo M, Moothart C, Sigmund CD, Hosokawa R, Chai Y, Engelhardt JF. Wnt3a Regulates Lef-1 Expression During Airway Submucosal Gland Morphogenesis. Developmental biology. 2007;305(1):90-102. doi:10.1016/j.ydbio.2007.01.038.
• Liu X, Driskell RR, Engelhardt JF. Stem Cells in the Lung. Methods in enzymology. 2006;419:285-321. doi:10.1016/S0076-6879(06)19012-6.
• Liu X, Driskell RR, Engelhardt JF. Airway glandular development and stem cells. Current Topics in Developmental Biology Current Topics in Developmental Biology Volume 64. 2004:33-56. doi:10.1016/s0070-2153(04)64003-8.
• Liu X, Driskell RR, Luo M, Abbott D, Filali M, Cheng  N, Sigmund CD, Engelhardt JF. Characterization of Lef-1 Promoter Segments that Facilitate Inductive Developmental Expression in Skin. The Journal of investigative dermatology. 2004;123(2):264-274. doi:10.1111/j.0022-202X.2004.23201.x.
• Driskell RR, Liu X, Luo M, Filali M, Zhou W, Abbott D, Cheng N, Moothart C, Sigmund CD, Engelhardt JF. Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2004;287(4). doi:10.1152/ajplung.00026.2004.
• Liu X, Yan Z, Luo M, Zak R, Li Z, Driskell RR, Huang Y, Tran N, Engelhardt JF. Targeted correction of single-base-pair mutations with adeno-associated virus vectors under nonselective conditions. Journal of Virology. 2004;78(8):4165-4175. doi:10.1128/jvi.78.8.4165-4175.2004.
• Driskell RR, Engelhardt JF. Current Status of Gene Therapy for Inherited Lung Diseases. Annual review of physiology. 2003;65:585-612. doi:10.1146/annurev.physiol.65.092101.142426.