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MIN DU LABORATORY WEBSITE Nutrigenomics and Growth Biology

Peer Reviewed Publications in the Last 5 Years

  1. Chen, Y. T., Y. Hu, Q. Y. Yang, X. D. Liu, J. S. Son, J. M. de Avila, M. J. Zhu, and M. Du. (2020). Embryonic exposure to hyper glucocorticoids suppresses brown fat development and thermogenesis via REDD1. Science Bulletin, In press.
  2. Li, T., R. Chang, H. Zhang, Du, and X. Mao. (2020). Water extract of Potentilla discolor bunge improved hepatic homeostasis by regulating gluconeogenesis and glycogen synthesis in high-fat diet and streptozotocin-induced type I diabetic mice. Frontiers in Nutrition, 7: 161.
  3. Cai, X., S. Ding, Q. Shi, Z. Lyu, D. Liu, W.J. Dong, Du, P. Dutta, Y. Song, D. Du, Y. Lin. (2020). Eyeball-like yolk-shell bimetallic nanoparticles for synergistic photodynamic-photothermal therapy. ACS Applied Bio Materials, In press.
  4. Chen, Y.T., Y. Hu, Q.Y. Wang, J.S. Son, X.D. Liu, J.M. de Avila, M. J. Zhu, and M. Du. (2020). Excessive glucocorticoids during pregnancy impair fetal brown fat development and predisposes offspring to metabolic dysfunctions. Diabetes, 69: 1662-1674.
  5. Tian, Q., Z. Xu, X. Sun, J. Deavila, Du, and M. J. Zhu. (2020). Grape pomace inhibits colon carcinogenesis by suppressing cell proliferation and inducing epigenetic modifications. Journal of Nutritional Biochemistry, 84: 108443.
  6. Ren, L., Q. Li, X. Hu, Q. Yang, Du, Y. Xing, Y. Wang, J. Li, and L. Zhang. (2020). A novel mechanism of bta-miR-210 in bovine early intramuscular adipogenesis. Genes, 11:601.
  7. Li, T., Du, H. Wang, and X. Mao. (2020). Milk fat globule membrane and its component phosphatidylcholine induce adipose browning both in vivo and in vitro. Journal of Nutritional Biochemistry, 81: 108372.
  8. Chen, M., D. Geng, X. Yang, X. Liu, S. Liu, P. Ding, Y. Pang, R. F. Wang, Du, and X. Hu. (2020). In vitro nephrotoxicity induced by herb-herb interaction between Radix Glycyrrhizae and Radix Euphorbiae Pekinensis. Oxidative Medicine and Cellular Longevity, 6894751.
  9. Tian Q.Y., X.D. Liu, and Du. (2020). Alpha-ketoglutarate for adipose tissue rejuvenation. Aging, 12: 13845-13846.
  10. Bordbar F., J. Jensen, Du, A. Abied, W. Guo, L. Xu, H. Gao, L. Zhang, and J. Li. (2020). Identification and validation of a novel candidate gene regulating net meat weight in Simmental beef cattle based on imputed next-generation sequencing. Cell Proliferation, 53: e12870.
  11. Hu, Y., Y. Feng, L. Zhang, Y. Jia, D. Cai, S.B. Qian, Du, and R. Zhao. (2020). GR-mediated FTO transactivation induces lipid accumulation in hepatocytes via demethylation of m6A on lipogenic mRNAs. RNA Biology, 17: 930-942.
  12. Sun, J., L. Zhao, Y. Chen, K. Chen, S. A. Chae, J. M. de Avila, H. Wang, M.J. Zhu, Z. Jiang, and Du. (2020). Maternal exercise via exerkine apelin enhances brown adipogenesis and prevents metabolic dysfunction in offspring mice. Science Advances, 6: eaaz0359. This paper was featured by NIH (
    ) and received wide news coverage.
  13. Chen, Y., Y. Yang, and Du. (2018). Beyond brown adipogenesis the inheritance of imprinted H19. Non-coding RNA Investigation, 2:64.
  14. Wang, B., C. L. Harris, W. Nie, X. Fu, J. M. Deavila, M. J. Zhu, M. Maquivar, S. M. Parish, J. R. Busboom, M. L. Nelson, and Du. (2018). Neonatal vitamin A injection promotes cattle muscle development and increase oxidative muscle fibers. Journal of Animal Science and Biotechnology, 9: 82.
  15. Zhu, M.J., X. Sun, and Du. (2018). AMPK in regulation of apical junctions and barrier junction of intestinal epithelium. Tissue Barriers, 6: 1-13.
  16. McCallum, M. L., C. A. Pru, A. R. Smith, N. C. Kelp, N. Foretz, B. Viollet, Du, and J. Pru. (2018). A functional role of AMPK in female fertility and endometrial regeneration. Reproduction, 156: 501-513.
  17. Harris, C. L., B. Wang, J. M. Deavila, J. R. Busboom, M. Maquivar, S. M. Parish, B. McCann, M. L. Nelson, and M. Du. (2018). Vitamin A administration at birth promotes calf growth and marbling fat development in Angus beef cattle. Journal of Animal Science and Biotechnology, 9: 55.
  18. Ma, Y.N., B. Wang, Z.X. Wang, N. A. Gomez, M. J. Zhu, and M. Du. (2018). Three dimensional spheroid culture of adipose stromal vascular cells for studying adipogenesis in beef cattle. Animal, 12: 2123-2129.
  19. Zhao, L., T. Zou, N. A. Gomez, B. Wang, M. J. Zhu, and M. Du. (2018). Raspberry alleviates obesity-induced inflammation and insulin resistance in skeletal muscle through activation of AMP-activated protein kinase (AMPK) α1. Nutrition & Diabetes, 8: 39.
  20. Zhang, S., Y. Zhang, X. Zhou, X. Fu, J. Michal, G. Ji, M. Du, and Z. Jiang. (2018). Alternative polyadenylation drives genome-to-phenome information detours in the AMPKα1 and AMPKα2 knockout mice. Scientific Report, 8: 6462.
  21. Li, T., J. Gao, M. Du, J. Song, and M. Du. (2018). Milk fat globule membrane attenuates high-fat diet-induced obesity by inhibiting adipogenesis and increasing uncoupling protein 1 expression in white adipose tissue of mice, Nutrients, 10: 331.
  22. Zou, T., B. Wang, Q. Yang, J. M. de Avila, M. J. Zhu, J. You, D. Chen, and M. Du. (2018). Raspberry promotes brown and beige adipocyte development in mice fed high-fat diet through activation of AMP-activated protein kinase (AMPK) a1. Journal of Nutritional Biochemistry, 55: 157.
  23. Gao, J., J. Song, M. Du, and X. Mao. (2018). Bovine a-lactalbumin hydrolysates (a-LAH) ameliorate adipose insulin resistance and inflammation in high-fat-diet-fed C57BL/6J mice. Nutrients, 10: 242.
  24. Ma, Y.N., B. Wang, Z.X. Wang, N. A. Gomez, M. J. Zhu, and M. Du. (2018). Three dimensional spheroid culture of adipose stromal vascular cells for studying adipogenesis in beef cattle. Animal, 10: 242.
  25. Sun, X., X. Fu, M. Du, and M. J. Zhu. (2018). Ex vivo gut culture for tracing gut epithelial development. Open Biology, 8: 170256.
  26. Sun, X., M. Du, D. A. Navarre and M. J. Zhu. (2018). Purple potato extract promotes intestinal epithelial differentiation and barrier function by activating AMP-activated protein kinase. Molecular Nutrition and Food Research, 62: 1700536.
  27. Maricelli, J. A., Y. M. Bishaw, B. Wang, M. Du, and B. D. Rodgers. (2018). Systemic SMAD7 gene therapy increases striated muscle mass and enhances exercise capacity in a dose-dependent manner. Human Gene Therapy, 29: 390-399.
  28. Son, J. S., S. A. Chae, E. D. Testroet, M. Du, and H. Jun. (2018). Exercise-induced myokines: a brief review of controversial issues of this decade. Expert Review of Endocrinology & Metabolism, 13: 51-58.
  29. Chen, Y., Y. Liu, M. Du, W. Zhang, L. Xu, X. Gao, L. Zhang, H. Gao, L. Xu, J. Li, M. Zhao. (2017). Constructing a comprehensive gene co-expression based interactome in Bos Taurus. PeerJ, 5: e4107.
  30. Wang, B., F. Zhang, H. Zhang, Z. Wang, Y. Ma, M. J. Zhu, and M. Du. (2017). Alcohol intake aggravates adipose browning and muscle atrophy in cancer associated cachexia. Oncotarget, 8: 100411-100420.
  31. Bibi, S., Y. Kang, M. Du, and M. J. Zhu. (2017). Dietary red raspberries attenuate dextran sulfate sodium-induced acute colitis. Journal of Nutritional Biochemistry, 51: 40-46.
  32. Wang, B., X. Fu, X. Liang, J. M. Deavila, Z. Wang, L. Zhao, Q. Tian, J. Zhao, N. A. Gomez, S. C. Trombetta, M. J. Zhu, and M. Du. (2017). Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRa+ adipose progenitors. Cell Discovery, 3:17036.
  33. Fu, X., Q. Yang, B. Wang, J. Zhao, M. Zhu, S. M. Parish, and M. Du. (2017). Reduced satellite cell density and myogenesis in Wagyu compared to Angus cattle as a possible explanation of its high marbling. Animal, 9: 1-8.
  34. Gao, P. F., X. H. Guo, M. Du, G. Q. Cao, Q. C. Yang, Z. D. Pu, Z. Wang, Q. Zhang, M. Li, Y. S. Jin, X. J. Wang, H. Liu, and B. G. Li. (2017). LncRNAs profiling of skeletal muscles in Large White pigs and Mashen pigs during development. Journal of Animal Science, 95: 4239-4250.
  35. Li, T., X. Cheng, M. Du, B. Chen, and X. Y. Mao. (2017). Upregulation of heme oxygenase-1 mediates the anti-inflammatory activity of casein glycomacropeptide (GMP) hydrolysates in LPS-stimulated macrophages. Food & Function, 8: 2475-2484.
  36. Wang, B., Z. Wang, M. de Avila, M. J. Zhu, F. Zhang, N. A. Gomez, L. Zhao, Q. Tian, J. Zhao, J. Maricelli, H. Zhang, B. D. Rodgers,and M. Du. (2017). Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevating retinoic acid signaling. FASEB Journal, 31: 4612-4622.
  37. Wang, B., X. Fu, M.J. Zhu, and M. Du. (2017). Retinoic acid inhibits white adipogenesis by disrupting GADD45A mediated Zfp423 DNA demethylation. Journal of Molecular Cell Biology, 9: 338-349.
  38. Zhao, J., Y. Jin, M. Du, W. Liu, Y. Ren, C. Zhang, J. Zhang. (2017). The effect of dietary grape pomace supplementation on epididymal sperm quality and testicular antioxidant ability in ram lambs. Theriogenology, 97: 50-56.
  39. Xue, Y., M. Du, H. Sheng, C. J. Hovde, and M. J. Zhu. (2017). Escherichia coli O157:H7 suppress host autophagy and promote bacterial adhesion via Tir-mediated and cAMP-independent activation of protein kinase A. Cell Death and Discovery, 3, 17055.
  40. Zhao, J. X., R. Su, W. Liu, Y. Ren, C. Zhang, M. Du, and J. Zhang. (2017). Effect of dietary Tartary buckwheat extract supplementation on growth performance, meat quality and antioxidant activity in ewe lambs. Meat Science, 134: 79-85.
  41. Zhao, J., Q. Yang, L. Zhang, X. Liang, X. Sun, B. Wang, Y. Chen, M. J. Zhu, and M. Du. (2017). AMPKa1 deficiency suppresses brown adipogenesis in favor of fibrogenesis during brown adipose tissue development. Biochemical and Biophysical Research Communications, 491: 508-514.
  42. Du, M., S.P. Ford, and M. J. Zhu. (2017). Optimizing livestock production efficiency through maternal nutritional management and fetal developmental programming. Animal Frontiers, 7: 5-11.
  43. Sun, X. X. Fu, Q. Y. Yang, M. Du, and M. J. Zhu. (2017). AMPK regulate intestinal differentiation via histone modification of CDX2. Cell Death and Differentiation, 24: 819-831.
  44. Xue Y., M. Du, and M. J. Zhu. (2017). Quercetin suppresses NLRP3 inflammasome activation in epithelial cells triggered by Escherichia coli O157:H7. Free Radical Biology & Medicine, 108: 760-769.
  45. Song, J., Q. Wang, M. Du, X. Ji, and X. Mao. (2017). Identification of dipeptidyl peptidase-IV inhibitory peptides from mare whey protein hydrolysates. Journal of Dairy Science, 100: 6885-6894.
  46. Wang, S., X. Liang, Q. Yang, X. Fu, M. Zhu, B.D. Rodgers, Q. Jiang, M. V. Dodson, and M. Du. (2017). Resveratrol enhances brown adipocyte formation and function by activating AMP-activated protein kinase (AMPK) a1 in mice fed high-fat diet. Molecular Nutrition and Food Research, 61: 1600746.
  47. Song, J.J., Q. Wang, M. Du, T. G. Li, B. Chen, X. Y. Mao. (2017). Casein glycomacropeptide-derived peptide IPPKKNQDKTE ameliorate high glucose-induced insulin resistance in HepG2 cells via activation of AMPK signaling. Molecular Nutrition and Food Research, 61: 1600301.
  48. Yang, G., S. Bibi, M. Du, T. Suzuki, and M. J. Zhu. (2017). Regulation of the intestinal tight junction by natural polyphenols: a mechanistic perspective. Critical Reviews in Food Science and Nutrition, 595: 1547-1562.
  49. Griner, J. D., C. J. Rogers, M. J. Zhu, and M. Du. (2017). Lysyl oxidase propeptide promotes adipogenesis through inhibition of FGF-2 signaling. Adipocyte, 6: 12-19.
  50. Zou, T., Q. Yang, B. Wang, M. Zhu, P. W. Nathanielsz, and M. Du. (2017). Resveratrol supplementation to high fat diet-fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring. Journal of Physiology, 595: 1547-1562.  This is an Editor’s choice article and was further highlighted by a Translational Perspective: Aiken C. E., and S. E. Ozanne, Breaking the cycle of intergenerational obesity, Journal of Physiology 595: 1443-1444.
  51. Li T., B. Chen, M. Du, J. Song, X. Cheng, X. Wang, and X. Mao. (2017). Casein glycomacropeptide hydrolysates exert cytoprotective effect against cellular stress by upregulating HO-1 expression in HepG2 cells. Nutrients, 9:31.
  52. Xue, Y., S. Zhang, M. Du, and M. J. Zhu. (2017). Dandelion extract suppresses reactive oxidative species and inflammasome in intestinal epithelial cells. Journal of Functional Food, 29: 10-18.
  53. Kang, Y., Xue, Y., M. Du, M. J. Zhu. (2016). Preventive effects of Goji berry on dextran sulfate sodium induced colitis in mice. Journal of Nutritional Biochemistry, 40: 70-76.
  54. Liang, X. W., Q. Y. Yang, L. P. Zhang, J. Maricelli, B. D. Rodgers, M. J. Zhu, and M. Du (2016). Maternal high-fat diet during lactation impairs thermogenic function of brown adipose tissue in offspring mice. Scientific Reports, 6: 34345.
  55. Yang, Q., X. Liang, X. Sun, L. Zhang, X. Fu, C. J. Rogers, A. Berim, S. Zhang, S. Wang, B. Wang, M. Foretz, B. Viollet, D. R. Gang, B. D. Rodgers, M. Zhu, and M. Du. (2016). AMPK/α-ketoglutarate axis dynamically mediates DNA demethylation in the Prdm16 promoter and brown adipogenesis. Cell Metabolism, 24: 542-554.  This paper was featured in Editors’ Choice, Science Signaling (Nancy R. G., Improving the health of newborns of obese mothers. Sci. Signal. 2016, 451: ec246)
  56. Wei, S. J., M. Du, Z. H. Jiang, G. J. Hausman, L. F. Zhang, and M. V. Dodson. (2016). Long noncoding RNAs in regulating adipogenesis: new RNAs shed lights on obesity. Cellular and Molecular Life Sciences, 73: 2079-2087.
  57. Zhu, H. M., M. Du, L. K. Fox, and M. J. Zhu. (2016). Bactericidal effects of Cinnamomum cassia oil against bovine mastitis bacterial pathogens. Food Control, 66: 291-299.
  58. Bibi, S., Y. Kang, G. Yang, M. Du, and M. J. Zhu. (2016). Grape seed extract improves small intestinal morphology through suppressing inflammation and regulating alkaline phosphatase in IL10-deficient mice. Journal of Functional Foods, 20: 245-252.
  59. Wang, B., Q. Yang, C. L. Harris, M. L. Nelson, J. R. Busboom, M. J. Zhu, and M. Du. (2016). Nutrigenomic regulation of adipose tissue development – role of retinoic acid. Meat Science, 120: 100-106.
  60. Liang, X., Q. Yang, X. Fu, C. J. Rogers, B. Wang, H. Pan, M. J. Zhu, P. W. Nathanielsz, and M. Du. (2016). Maternal obesity epigenetically alters visceral fat progenitor cell properties in male offspring mice. Journal of Physiology, 594: 4453-4466.  This is an Editor’s choice article
  61. Campos, C. F., M. S. Duarte, S. E. F. Guimaraes, L. L. Verardo, S. Wei, M. Du, Z. Jiang, W. G. Bergen, G. J. Hausman, M. Fernyhough-Culver, E. Albrecht, and M. V. Dodson. (2016). Review: Animal model and the current understanding of molecular dynamics of adipogenesis. Animal, 10: 927-932.
  62. Li, N., Q. Y. Yang, R. Walker, T.B. Thompson, M. Du, and B. R. Rodgers. (2016). Myostatin attenuation in vivo reduces adiposity, but activates adipogenesis. Endocrinology, 157: 282-291.
  63. Miao, Z. G., L. P. Zhang, X. Fu, Q. Y. Yang, M. J. Zhu, M. V. Dodson, and M. Du. (2016). Invited review: Mesenchymal progenitor cells in intramuscular connective tissue development. Animal, 10: 75-81.
  64. Fu, X., M. J. Zhu, S. Zhang, F. Marc, V. Benoit, and M. Du. (2016). Obesity impairs skeletal muscle regeneration via inhibition of AMP-activated protein kinase. Diabetes. 65: 188-200.
  65. Zhang, H., M. Du, Q. Yang, and M. J. Zhu. (2016). Butyrate suppresses murine mast cell proliferation and cytokine production through inhibiting histone deacetylase. Journal of Nutritional Biochemistry, 27: 299-306.