_{Paine Research Group}

Lab News

Awards and Achievements

Mary Paine received the 2023 College of Pharmacy and Pharmaceutical Sciences Faculty Excellence Award
Mary Paine received the 2023 Rawls-Palmer Progress in Medicine Award from the ASCPT
Rakshit Tanna received the 2023 ASCPT Presidential Trainee Award
James Nguyen received a 2023 ASCPT Student Travel Award
Rakshit Tanna received the best platform presentation award in the graduate student category at the PANWAT 2022 Regional Toxicology Conference on October 3, 2022
Mary Paine received the WSU Spokane Chancellor’s Award for Excellence in Research
Rakshit Tanna received the 2021-2022 WSU Pharmaceutical Sciences Graduate Student of the Year award
Rakshit Tanna won second place in the poster competition at the 20th Annual ICSB on March 28, 2022
James Nguyen won third place in the poster competition at the 20th Annual ICSB on March 28, 2022
James Nguyen received the Ruth L. Kirschstein Predoctoral Individual National Research Service Award in 2021
James Nguyen received the NIH Loan Repayment Program Award in 2021

Poster Presentations

4.24.2023 | Clinical pharmacokinetics of a cannabidiol/cannabidiolic acid-rich hemp product was presented at the 21st Annual ICSB in Oxford, MS. Cherel MG, Nguyen JT, Davy RJ, Cope VL, Hadi DL, Layton ME, White JR, Paine MF.
3.24.2023 | Clinical assessment of the drug interaction potential of the psychotropic natural product kratom (Mitragyna speciosa) was presented at the American Society for Clinical Pharmacology and Therapeutics (ASCPT) 2023 Annual Meeting in Atlanta, Georgia. 1. Tanna RS, Nguyen JT, Hadi DL, Layton ME, White JR, Cech NB, Oberlies NH, Rettie AE, Thummel KE, Paine MF.
10.14.2022 | Extending the OMOP standard vocabulary to include botanical natural products was presented at the 2022 OHDSI Symposium in Rockville, MD. Taneja SB, Paine MF, Kane-Gill SL, Boyce RD.
9.14.2022 |Physiologically based pharmacokinetic models for kratom, a botanical with opioid-like effects, and kratom-drug interactions mediated by CYP3A and CYP2D6 was presented at the 13th ISSX meeting in Seattle, WA. 2. Tanna RS, Nguyen JT, Cech NB, Oberlies NH, Rettie AE, Thummel KE, and Paine MF.
03.28.2022 | Elucidating mechanisms underlying the goldenseal-midazolam interaction using a modeling and simulation approach was presented at the 20th Annual ICSB in Oxford, MS. Nguyen JT.
03.28.2022 | Clinical assessment of the drug interaction potential of the psychotropic natural product kratom was presented at the 20th Annual ICSB in Oxford, MS. Tanna, RS.
03.24.2022 | Relation extraction from biomedical literature on pharmacokinetic natural product-drug interactions was presented at the AMIA 2022 Informatics Summit in Chicago, IL. Taneja SB, Ndungu PW, Paine MF, Kane-Gill SL, Boyce RD.
09.13.2021 | Clinical pharmacokinetic assessment of kratom (mitragyna speciosa), a botanical with opioid-like effects was presented virtually at the 24th North American ISSX meeting. Tanna, RS.
08.13.2021 | Clinical pharmacokinetic assessment of kratom (mitragyna speciosa), a botanical with opioid-like effects was presented at the Annual College of Pharmacy and Pharmaceutial Sciences Research Day. Tanna, RS.
07.25.2021 | Designing potential extensions from G-SRS to ChEBI to identify natural product-drug interactions was presented virtually at ISMB/ECCB 2021. Taneja SB, Callahan TJ, Brochhausen M, Paine MF, Kane-Gill SL, Boyce RD.
07.28.2019 | Assessing the predictive performance of in silico generated binding parameters for various natural product constituents was presented at the 12th International ISSX meeting in Portland, OR. Nguyen, JT.
07.28.2019 | The natural product kratom is a potential precipitant of pharmacokinetic interactions with common drugs of abuse was presented at the 12th International ISSX meeting in Portland, OR. Tanna RS.
07.08.2019 | Assessing transporter-mediated goldenseal-drug interactions in healthy volunteers using a transporter cocktail was presented at the Gordon Research Conference on Drug Metabolism 2019 in Holderness, NH. Tanna RS.
07.04.2019 | Determining mechanisms underlying the goldenseal-midazolam interactions in humans using an in vitro to in vivo approach was presented at the Gordon Research Conference on Drug Metabolism 2019 in Holderness, NH. Tanna RS, Tian DD, McDonald MG, Calamia J, Rettie AE, Thummel KE, Paine MF.
04.06.2019 | Determining mechanisms underlying the goldenseal-midazolam interactions in humans using an in vitro to in vivo approach was presented at the ASPET Annual Meeting at Experimental Biology 2019 in Orlando, FL. Tanna RS, Tian DD, McDonald MG, Calamia J, Rettie AE, Thummel KE, Paine MF
Pictured from left to right: Dr. Mary Paine, Dr. Dandan Tian, Rakshit Tanna.

03.22.2018 | Green tea decreases raloxifene systemic exposure to below the pre-defined no effect range in healthy volunteers was presented at the ASCPT Annual Meeting in Orlando, FL.
McCune JS, Tian DD, Hardy PA, Cech NB, Shen DD, Layton ME, White JR, Paine MF.
11.06.2017 | Toward a Reliable and Interoperable Public Repository for Natural Product-Drug Interaction Study Data was presented at the 2017 Annual Symposium of the American Medical Informatics Association in Washington, DC. Boyce RD, Ragueneau-Majlessi I, Yu J, Sontheimer J, Kinsella K, Brochhausen M, Judkins J, Pinkleton B, Cooney R, Paine MF, McCune JS.
07.11.2017 | Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea Using a Biochemometric Approach was presented at the Gordon Research Conference on Drug Metabolism in Holderness, NH. Tian DD, Kellogg JJ, Oberlies NH, Cech NB, McCune JS, Paine MF.
06.21.2017 | Biochemometrics to Identify Drug Metabolizing Enzyme Inhibitors from Green Tea (Camellia sinensis) was presented at the 8th American Council for Medicinally Active Plants Conference in Clemson, SC. Okut N, Kellogg JJ, Tian DD, Paine MF, Oberlies NH, Cech NB.

Invited Oral Presentations

01.31.2023 | Paine MF: “Deciphering mechanisms underlying natural product-drug interactions to improve pharmacotherapy.” 7th Asia Pacific ISSX Meeting, Bangalore, India
10.03.2022 | Tanna RS: “Clinical assessment of the drug interaction potential of the psychotropic natural product kratom.” Pacific Northwest Association of Toxicologists 2022 Regional Toxicology Conference.
09.15.2022 | Tanna RS: “Physiologically based pharmacokinetic models for kratom, a botanical with opioid-like effects, and kratom-drug interactions mediated by CYP3A and CYP2D6.” WSU College of Pharmacy and Pharmaceutical Sciences Industry Advisory Board meeting.
06.10.2021 | Nguyen JT: “Natural products: a safe bet?” WSU College of Pharmacy and Pharmaceutical Sciences Industry Advisory Board meeting.
06.10.2021 | Tanna RS: “Prediction and clinical assessment of the pharmacokinetic drug interaction potential of the psychotropic natural product kratom.” WSU College of Pharmacy and Pharmaceutical Sciences Industry Advisory Board meeting.
06.08.2021 | Paine MF: “Uncovering Transporter-Mediated Natural Product-Drug Interactions Using Translational Tools.” International Society for the Study of Xenobiotics Webinar. Virtual.
06.01.2021 | Paine MF: “Translational Approaches to Untangle Herb-Drug Interactions.” 11^th International Marbach DDI workshop. Virtual.
05.29.2021 | Paine MF: “Natural Product-Drug Interaction Research: Digging through the Intricacies to Uncover Mechanisms and Improve Pharmacotherapy.” FDA-ASCPT William Abrams Award lecture. Virtual.
03.09.2021 | Paine MF: “Weeding Mechanisms of Pharmacokinetic Marijuana-Drug Interactions.” American Society for Clinical Pharmacology and Therapeutics (ASCPT) annual meeting. Virtual.
11.24.2019 | Paine MF: “Assessing clinical transporter-mediated herb-drug interactions using a cocktail approach.” 4^th International Ling-nan DMPK Forum in Guangzhao, China.
08.14.2019 | Paine MF: “Natural product-drug interaction research: cultivating best practices.” Linus Pauling Institute 10^th International Conference in Corvallis, OR.
07.28.2019 | Paine MF: “Translational approaches to assess pharmacokinetic herb-drug interactions.” 12^th international ISSX meeting in Portland, OR.
07.04.2019 | “Assessing Transporter-Mediated Goldenseal-Drug Interactions in Healthy Volunteers Using a Transporter Cocktail” was presented at the Gordon Research Conference on Drug Metabolism in Holderness, NH. Tanna RS, Nguyen J, Basal S, Molnár B,
Horváth M, Kellogg JJ, Cech NB, Oberlies NH, Shierman LM, Unadkat JD, Thummel KE, Paine MF.

Rakshit Tanna, located second from the left of the photo, is presented here with an official Certificate of Oral Presentation for his presentation “Assessing Transporter-Mediated Goldenseal-Drug Interactions in Healthy Volunteers Using a Transporter Cocktail” at the Gordon Research Conference on Drug Metabolism 2019.
06.23.2019 | Paine MF: “Untangling mechanisms underlying natural product-drug interactions. ” International Conference on Cytochrome P450 in Brisbane, Australia.
04.06.2019 | Paine MF: “Translational approaches to address potential clinically significant enteric xenobiotic-drug interactions: a case study involving the herbal product green tea.” EB/ASPET Annual Meeting in Orlando, FL.
03.10.2019 | Paine MF: “Causative ingredients and mechanisms underlying interactions between prescription and non-prescription medications and natural products.” Society of Toxicology 58^th Annual Meeting in Baltimore, MD.
10.03.2018 | Paine MF: “Evaluating potential cannabis-drug interactions.” Cannabis Research Retreat in Seattle, WA.
06.14.2018 | Paine MF: “Assessing Pharmacokinetic Natural Product-Drug Interactions: Challenges and Opportunities.” Delaware Valley Drug Metabolism Discussion Group – Rozman Memorial Symposium: Contributions of Women Scientists to Drug Metabolism, Drug Transporter, and Pharmacokinetics Research in Philadelphia, PA.
06.05.2018 | Paine MF: “Assessing a Pharmacokinetic Green Tea-drug Interaction from Bench to Bedsides” FDA, Center for Drug Evaluation and Research, Office of Clinical Pharmacology in Silver Spring, MD.
05.25.2018 | Paine MF: “Natural Product-drug Interactions: Progress Towards Recommend-ed Approaches” FDA, Center for Drug Evaluation and Research, Office of Clinical Pharmacology in Silver Spring, MD.
11.07.2017 | Kellogg JJ, Tian DD, Oberlies NH, Paine MF, Cech NB: “Biochemometric Analysis Identifies Drug Metabolizing Enzyme Inhibitors from Green Tea (Camellia sinensis).” 2017 Southeast Regional Meeting of the American Chemical Society in Charlotte, NC.
11.03.2017 | Paine MF: “A Systematic Approach to Select and Evaluate Natural Products as Precipitants of Pharmacokinetic Natural Product-Drug Interactions” 2nd Annual Joint CNPHARS-ASPET Meeting on Pharmacology in Hangzhou, China.
08.21.2017 | Paine MF: “Intestinal UGTs as Targets for Pharmacokinetic Natural Product-Drug Interactions” 254th American Chemical Society National Meeting in Washington, DC.
07.11.2017 | Paine MF: “Identification of Natural Products as Precipitants of Clinical Drug Interactions: Challenges and Opportunities” Gordon Research Conference on Drug Metabolism in Holderness, NH.
10.26.2016 | Paine MF: “Natural Product-Drug Interaction Research: the Roadmap to Best Practices” Council for Responsible Nutrition Day of Science in Dana Point, CA.

Symposiums

07.2019 | Mary Paine served as chair at the Gordon Research Conference on Drug Metabolism, in Holderness, NH “Translational approaches to untangle xenobiotic-drug interaction mechanisms and improve pharmacotherapy”
Gordon Research Conference (GRC) Drug Metabolism Conference 2019 attendees.

Located from left to right: John Rodgers, Dr. Bhagwat Prasad, Dr. Mary Paine, Dr. Erickson Paragas, Dr. Sarah Humphries, Armina Abbasi, Rakshit Tanna.
04.06.19 | Mary Paine and Amy Roe co-chaired at the Experimental Biology/American Society for Pharmacology & Experimental Therapeutics symposium in Orlando, FL: “Natural Product-Drug Interactions: Complex Mechanisms and Public Health Impact”.

Miscellaneous

12.2021 | Karen Vo was selected to participate in the FDA Pharmacy Student Experiential Program as part of her fourth year APPE rotations. She will be working with the pediatrics group in the Office of Clinical Pharmacology.
12.23.2020 | Rakshit Tanna was featured as the highlighted trainee author for The Journal of Pharmacology and Experimental Therapeutics January 2021 issue.
10.2020 | Dr. Mary Paine was featured as a guest editor in the October 2020 iss ue of Drug Metabolism and Disposition. This issue included a special section, “Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions”. Cover art by Sabrina Judson and co-designed with Dr. Mary Paine.

05.2020 | Karen Vo was featured in the first issue of the local magazine Eastsiders for her artwork.
05.2020 | James Nguyen received the Mylan Pharmaceuticals Excellence in Pharmacy Award for being in the top 25% of his class academically.
04.2020 | Karen Vo was featured in the college CougaRx April 2020 Newsletter for her art.
07.2019 | Science meeting with collaborators at Natty Greene’s in Greensboro, NC, July 22-23, 2019
Pictured from left to right: Front row: Dr. Laura Flores-Bocanegra, Dr. Huzefa Raja, Dr. Nadja Cech, Dr. Nicholas Oberlies, Dr. Mary Paine, Deena Hadi, Rakshit Tanna. Back row: Tyler Graf, Dr. Daniel Todd, Dr. Steve Polyak, Dr. Scott Hemby, Dr. Richard Boyce.
04.2019 | Chancellor of WSU Spokane, Dr. Daryll DeWald, sat down in an interview with Mary Paine to discuss her research.
09.2018 | Dr. Mary Paine and Amy Roe were co-editors for Clinical Pharmacy & Therapeutics themed issue on “Botanicals”

09.13.2017 – 09.15.2017 | Conference paper: Judkins J, Tay-Sontheimer J, Boyce RD, and Brochhausen M: “Extending the DIDEO Ontology to Include Entities from the Natural Product Drug Interaction Domain of Discourse” 6th International Workshop on Vaccine and Drug Ontology Studies, International Conference on Biomedical Ontology, Newcastle University, UK.
10.25.2017 | Webinar: Paine MF: “Natural Product-Drug Interactions: Case Studies from the NaPDI Center” SOLVO Biotechnology.