WSU’s Tissue Imaging and Proteomics Laboratory (TIPL)
is a metabolomics- and proteomics-based facility that applies mass spectrometry-based technologies to significant biological problems.
TIPL is a University service center that analyzes samples from a wide range of projects from across the different WSU campuses and from non-WSU clients.
In TIPL, we focus on the development, advancement, and application of leading-edge instrumentation techniques for the large-scale profiling and identification of the functional products of gene expression, namely proteins and metabolites.
Profiling large numbers of proteins and metabolites provides a high resolution view of the biochemical phenotype. Comparative profiling provides detailed quantitative and qualitative data that are highly valuable in gene validation, gene discovery, mechanistic insight investigations, leading to a better understanding of the cellular response of an organism to external stimuli. Co-analysis of expression profiles with genetic information also provides a unique way to understand gene function and the interrelationships between genes.
As indicated by the lab’s name, a primary focus of TIPL is the development and application of mass spectrometry-based tissue imaging techniques, also called mass spectrometry imaging or imaging mass spectrometry (IMS), in the biological and life sciences, with a goal to further our understanding of metabolic processes within all types of organisms, from animals to plants to microbes, at the tissue and potentially cellular level. We hope to eventually be able to apply such techniques to monitor biochemical processes at the subcellular level once the technology achieves high enough spatial resolution.
Our proteomic services include protein identification and protein quantification from a wide variety of sample types from simple to complex mixtures, as well as identification of post-translational modifications of proteins. Our instrumentation also allows for IMS of proteins within biological tissues.
Contact us to discuss how proteomics, metabolomics and tissue imaging can be applied in your research.