Background

 

The research in Prasad lab focusses on the prediction of inter-individual differences in drug disposition and response. Prasad lab utilizes quantitative mass spectrometry (targeted and untargeted proteomics and metabolomics) to quantify drug metabolizing enzymes, transporters and endogenous metabolites in human tissues and biofluids. These data along with genomics information and in vitro data are integrated into physiologically-based pharmacokinetic (PBPK) models to predict variability in drug and endobiotic disposition. The integrated genomics-proteomics-metabolomics approach is further applied to discover specific biomarkers of drug metabolizing enzymes and transporters for predicting disposition and response of xeno- and endo-biotics in special populations such as pediatrics where clinical data are not generally available. For more information, please see ‘Drug dosing for children‘.

 

Research problem: Lack of translation from bench-to-bedside

 

Research focus: Quantitative proteomics informed PBPK modeling