Position:
PhD Student
Education
- Master of Science in Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar, India
- Bachelor of Pharmacy, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), University of Delhi, India
- Diploma of Pharmacy, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), University of Delhi, India
Research Interests
- Enzyme- and transporter-mediated drug disposition
- In vitro–in vivo extrapolation (IVIVE)
- PBPK modeling for prediction of pharmacokinetics in special populations
About
Aarzoo is a Ph.D. student in the College of Pharmacy and Pharmaceutical Sciences at the Washington State University (WSU), Spokane. She is a pharmacist by profession. During Masters, her project focused on prediction of oral drug absorption using different physiologically based pharmacokinetic (PBPK) modeling software. Thereafter, she worked as a Research Officer at Agency for Science, Technology and Research (A*STAR), Singapore for ~1.5 years. At A*STAR, she was involved in projects on mechanistic prediction of disposition of drugs and environmental toxicants using different in vitro and in silico tools.
Publications:
- Thakur A., Tan, Z., Kameyama, T., El-Khateeb, E., Nagpal, S., Malone, S., Jamwal, R. & Nwabufo, C.K. (2021) Bioanalytical strategies in drug discovery and development. Drug metabolism reviews, 53(3): 434-458 (IF 4.5).
- Thakur A.#, Pervez M.#, Prasad B, Leeder S., Ontogeny of drug metabolizing enzymes. In: Nagar S., Argikar U., Tweedie D., (Eds.), Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications, (2nd ), 2021, 551-593.
#Equal contribution - Chapa R., Li C.Y., Basit A., Thakur A., Ladumor M.K., Sharma S., Singh S., Selen A. & Prasad B. (2020) Contribution of uptake and efflux transporters to oral pharmacokinetics of furosemide. ACS Omega, 5(51): 32939-32950 (IF 3.5).
- Thakur A.#, Tan S.P.F# & Chan J.C.Y. (2020) Physiologically-based pharmacokinetic modeling for predicting the clinical efficacy of the coadministration of lopinavir and ritonavir against SARS-CoV-2. Clinical Pharmacology & Therapeutics, 108(6):1176-1184 (IF 6.565). #Equal contribution
- Ladumor M.K., Thakur A., Sharma S., Rachapally A., Mishra S., Bobe P., Rao K., Pammi P., Kangne H., Levi D., Balhara A., Ghandikota S., Joshi A., Nautiyal V., Prasad B. & Singh S. (2019) An open access repository of protein abundance data of drug metabolizing enzymes and transporters for applications in physiologically based pharmacokinetics (PBPK) modelling and simulation. Scientific Reports-Nature, 9(1):9709 (IF 4.53).
- Ladumor M.K., Bhatt D.K., Gaedigk A., Sharma S., Thakur A., Pearce R.E., Leeder J.S., Bolger M.B., Singh S., & Prasad B. (2019) Ontogeny of hepatic sulfotransferases (SULTs) and prediction of age-dependent fractional contribution of sulfation in acetaminophen metabolism. Drug Metabolism and Disposition, 47(8): 818-831 (IF 3.35).
Posters:
- Thakur A., Singh D.K., Paine M.F., & Prasad B. Identification of putative novel biomarkers of organic anion transporter 1 and 3 for the prediction of transporter-mediated drug-drug interactions. Presented at ASPET Annual Meeting 2023, St. Louis, Missouri, 18th to 21st May 2023.
- Thakur A., Mettu V, Nguyen J.Y., Paine M.F., & Prasad B. Rat as a model for predicting human renal organic anion transporter-mediated drug-drug interactions. Presented at International Society for the Study of Xenobiotics (ISSX) Meeting 2022, Seattle, United States, 11th to 14th September 2022.
- Thakur A. & Prasad B. Assessing the effect of organic anion transporter inhibition on circulating pyridoxic acid, an endogenous transporter biomarker, using physiologically-based pharmacokinetic modeling. Presented at ASPET Annual Meeting, EB 2022, Philadelphia, United States, 2nd to 5th April 2022.
Contact:
Telephone: (509) 368-6535
Email: aarzoo.thakur@wsu.edu
Office Location: Pharmaceutical & Biomedical Sciences Building, Room# PBS-320, Spokane, WA