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Position:

Research Associate

Education:

  • Ph.D. in Pharmaceutical Chemistry, Bombay College of Pharmacy, University of Mumbai, India
  • Masters in Pharmacy, Bombay College of Pharmacy, University of Mumbai, India
  • Bachelor in Pharmaceutical Sciences – Mumbai Educational Trust’s Institute of Pharmacy, University of Mumbai, India

Research Interests:

  • In vitro ADME assays to address specific challenges related to in vitro in vivo extrapolation
  • Drug-drug interactions, precision medicine, and clinical pharmacokinetics

About:

Dr. Sandhya is a research associate in the Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University Spokane, WA. She has 8+ years of industrial experience in the drug metabolism and pharmacokinetics (DMPK) department of pharmaceutical companies such as Piramal Healthcare and Biocon Bristol Myers Squibb Research Center.

Her current research involves carrying out in vitro metabolism assays using a targeted proteomics approach, for the generation of relevant intersystem extrapolation and relative expression factors (ISEF and REF). These factors can then be applied for more accurate estimations of fraction metabolized (fm) for substrates of non-CYP enzymes and scaling of in vitro data for PBPK modeling.

Publications:

  1. Subash S, Singh DK, Ahire DS, Khojasteh SC, Murray BP, Zientek MA, Jones RS, Kulkarni P, Smith BJ, Heyward S, Cronin CN, Prasad B. “Dissecting parameters contributing to the underprediction of aldehyde oxidase-mediated metabolic clearance of drugs” Drug Metab Dispos.2023 Jul 10 DOI:10.1124/dmd.123.001379.
  2. Subash S, Gogtay NJ, Iyer KR, Gandhe P, Budania R, Thatte UM. Evaluation of vanillin as a probe drug for aldehyde oxidase and phenotyping for its activity in a Western Indian cohort Indian J Pharmacol 2021; 53:213-20. 
  3.  Subash S, Seervi M, Iyer K and Anagha Damre, Assessment of rat hepatic cytochrome P450 induction and inhibition potential of chlorogenic  acid. Indian Journal of Pharmaceutical Education and Research, Jan-Mar issue, vol 45, issue 1, 2011.  

Posters:

  1. Subash S, Ahire DS, Singh DK, Khojasteh SC, Murray BP, Zientek MA, Jones RS, Kulkarni P, Smith BJ, Heyward S, Cronin CN, & Prasad B. Proteomics-informed improved IVIVE of aldehyde oxidase mediated drug metabolism: The use of relative expression (REF) and inter system extrapolation factor (ISEF). Presented at Gordon Research Conference (GRC), Drug Metabolism Meeting 2022, Holderness, New Hampshire, 10th to 14th July 2022. 
  2. Subash S, Ahire DS, Khojasteh SC, Murray BP, Zientek MA, Jones RS, Kulkarni P, Smith BJ, Leeder SJ, Heyward S, & Prasad B. Ontogeny of human aldehyde oxidase. Presented at International Society for the Study of Xenobiotics (ISSX) Meeting 2022, Seattle, United States, 11th to 14th September 2022. 
  3. Subash S, Ahire DS, Singh DK, Khojasteh SC, Murray BP, Zientek MA, Jones RS, Kulkarni P, Zubair F, Smith BJ, Heyward S, & Prasad B. Is human liver microsomes a good in vitro model for dual substrates of CYP and CES enzymes? Presented at Gordon Research Seminar (GRS) and Conference (GRC) , Drug Metabolism Meeting 2023, Holderness, New Hampshire, 9th to 14th July 2023. 

Contact:

Telephone: (509) 368-6535

Email: sandhya.subash@wsu.edu

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Office Location: Pharmaceutical & Biomedical Sciences Building, Room # PBS-320