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Publications

2017

Xu M, Bhatt DK, Yeung CK, Claw KG, Chaudhry AS, Gaedigk A, Pearce RE, Broeckel U, Gaedigk R, Nickerson DA, Schuetz E, Rettie AE, Leeder JS, Thummel KE, Prasad B. Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver. J Pharmacol Exp Ther2017 Nov;363(2):265-274doi: 10.1124/jpet.117.243113. Epub 2017 Aug 17. PubMed PMID: 28819071; PubMed Central PMCID: PMC5697103.

Li CY, Lee S, Cade S, Kuo LJ, Schultz IR, Bhatt DK, Prasad B, Bammler TK, Cui JY. Novel Interactions between Gut Microbiome and Host Drug-Processing Genes Modify the Hepatic Metabolism of the Environmental Chemicals Polybrominated Diphenyl Ethers. Drug Metab Dispos2017 Nov;45(11):1197-1214doi: 10.1124/dmd.117.077024. Epub 2017 Sep 1. PubMed PMID: 28864748; PubMed Central PMCID: PMC5649562.

Bhatt DK, Gaedigk A, Pearce RE, Leeder JS, Prasad B. Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver. Drug Metab Dispos2017 Sep;45(9):1044-1048doi: 10.1124/dmd.117.076463. Epub 2017 Jun 12. PubMed PMID: 28607029; PubMed Central PMCID: PMC5563927.

Liao MZ, Gao C, Shireman LM, Phillips B, Risler LJ, Neradugomma NK, Choudhari P, Prasad B, Shen DD, Mao Q. P-gp/ABCB1 exerts differential impacts on brain and fetal exposure to norbuprenorphine. Pharmacol Res2017 May;119:61-71doi: 10.1016/j.phrs.2017.01.018. Epub 2017 Jan 19. PubMed PMID: 28111265; PubMed Central PMCID: PMC5392442.

Vrana M, Whittington D, Nautiyal V, Prasad B. Database of Optimized Proteomic Quantitative Methods for Human Drug Disposition-Related Proteins for Applications in Physiologically Based Pharmacokinetic Modeling. CPT Pharmacometrics Syst Pharmacol2017 Apr;6(4):267-276doi: 10.1002/psp4.12170. Epub 2017 Apr 4. PubMed PMID: 28074615; PubMed Central PMCID: PMC5397556.

Nyquist MD, Prasad B, Mostaghel EA. Harnessing Solute Carrier Transporters for Precision Oncology. Molecules2017 Mar 28;22(4)doi: 10.3390/molecules22040539. Review. PubMed PMID: 28350329; PubMed Central PMCID: PMC5570559.

Prasad B, Vrana M, Mehrotra A, Johnson K, Bhatt DK. The Promises of Quantitative Proteomics in Precision Medicine. J Pharm Sci2017 Mar;106(3):738-744doi: 10.1016/j.xphs.2016.11.017. Epub 2016 Dec 8. PubMed PMID: 27939376; PubMed Central PMCID: PMC5313344.

Boberg M, Vrana M, Mehrotra A, Pearce RE, Gaedigk A, Bhatt DK, Leeder JS, Prasad B. Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants. Drug Metab Dispos2017 Feb;45(2):216-223doi: 10.1124/dmd.116.072652. Epub 2016 Nov 28. PubMed PMID: 27895113; PubMed Central PMCID: PMC5267516.

Bhagwat Prasad,, Johnson K, Xiao G, Lai Y, Lee C, Ray AS, Liao M, Chu X, Salphati L, Mathias A, Humphreys W, Hop CE, Kumer S, Unadkat J. Protein Abundance of Phase I and II Drug Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhosis Livers. The FASEB Journal. 2017; 31:668.17-668.17.

Tanner JA, Prasad B, Claw KG, Stapleton P, Chaudhry A, Schuetz EG, Thummel KE, Tyndale RF. Predictors of Variation in CYP2A6 mRNA, Protein, and Enzyme Activity in a Human Liver Bank: Influence of Genetic and Nongenetic Factors. J Pharmacol Exp Ther2017 Jan;360(1):129-139doi: 10.1124/jpet.116.237594. Epub 2016 Nov 4. PubMed PMID: 27815364; PubMed Central PMCID: PMC5193072.

Prasad B. Quantitative analysis of hepatic transporters and DMEs during growth and development. Drug Metabolism and Pharmacokinetics. 2017; 32:S12doi: 10.1016/j.dmpk.2016.10.060.

Prasad B, Vrana M, Bhatt DK, Jha P, Nautiyal V, Zheng J. ADME QPrOmics MRM database: A repository of validated LC-MS/MS methods for ADME protein quantification. Drug Metabolism and Pharmacokinetics. ISSX, Busan,; 2017; Busan, North Korea. c.