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Publications

2018

Sawant-Basak A, Rodrigues AD, Lech M, Doyonnas R, Kasaian M, Prasad B, Tsamandouras N. Physiologically Relevant, Humanized Intestinal Systems to Study Metabolism and Transport of Small Molecule Therapeutics. Drug Metab Dispos2018 Nov;46(11):1581-1587doi: 10.1124/dmd.118.082784. Epub 2018 Aug 20. Review. PubMed PMID: 30126862.

Xu M, Saxena N, Vrana M, Zhang H, Kumar V, Billington S, Khojasteh C, Heyward S, Unadkat JD, Prasad B. Targeted LC-MS/MS Proteomics-Based Strategy To Characterize in Vitro Models Used in Drug Metabolism and Transport Studies. Anal Chem2018 Oct 16;90(20):11873-11882doi: 10.1021/acs.analchem.8b01913. Epub 2018 Sep 28. PubMed PMID: 30204418; PubMed Central PMCID: PMC6414395.

Zhang H, Basit A, Busch D, Yabut K, Bhatt DK, Drozdzik M, Ostrowski M, Li A, Collins C, Oswald S, Prasad B. Quantitative characterization of UDP-glucuronosyltransferase 2B17 in human liver and intestine and its role in testosterone first-pass metabolism. Biochem Pharmacol2018 Oct;156:32-42doi: 10.1016/j.bcp.2018.08.003. Epub 2018 Aug 4. PubMed PMID: 30086285; PubMed Central PMCID: PMC6188809.

Kumar V, Yin J, Billington S, Prasad B, Brown CDA, Wang J, Unadkat JD. The Importance of Incorporating OCT2 Plasma Membrane Expression and Membrane Potential in IVIVE of Metformin Renal Secretory Clearance. Drug Metab Dispos2018 Oct;46(10):1441-1445doi: 10.1124/dmd.118.082313. Epub 2018 Aug 9. PubMed PMID: 30093416; PubMed Central PMCID: PMC6130461.

Basit A, Amory JK, Prasad B. Effect of Dose and 5α-Reductase Inhibition on the Circulating Testosterone Metabolite Profile of Men Administered Oral Testosterone. Clin Transl Sci2018 Sep;11(5):513-522doi: 10.1111/cts.12569. Epub 2018 Jun 19. PubMed PMID: 29877607; PubMed Central PMCID: PMC6132360.

Li CY, Dempsey JL, Wang D, Lee S, Weigel KM, Fei Q, Bhatt DK, Prasad B, Raftery D, Gu H, Cui JY. PBDEs Altered Gut Microbiome and Bile Acid Homeostasis in Male C57BL/6 Mice. Drug Metab Dispos2018 Aug;46(8):1226-1240doi: 10.1124/dmd.118.081547. Epub 2018 May 16. PubMed PMID: 29769268; PubMed Central PMCID: PMC6053593.

Prasad B, Bhatt DK, Johnson K, Chapa R, Chu X, Salphati L, Xiao G, Lee C, Hop CECA, Mathias A, Lai Y, Liao M, Humphreys WG, Kumer SC, Unadkat JD. Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study. Drug Metab Dispos2018 Jul;46(7):943-952doi: 10.1124/dmd.118.080523. Epub 2018 Apr 25. PubMed PMID: 29695616; PubMed Central PMCID: PMC5987995.

Zou L, Stecula A, Gupta A, Prasad B, Chien HC, Yee SW, Wang L, Unadkat JD, Stahl SH, Fenner KS, Giacomini KM. Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity. Mol Pharmacol2018 Jul;94(1):689-699doi: 10.1124/mol.117.111153. Epub 2018 May 2. PubMed PMID: 29720497; PubMed Central PMCID: PMC5987998.

Bhatt DK, Basit A, Zhang H, Gaedigk A, Lee SB, Claw KG, Mehrotra A, Chaudhry AS, Pearce RE, Gaedigk R, Broeckel U, Thornton TA, Nickerson DA, Schuetz EG, Amory JK, Leeder JS, Prasad B. Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex. Drug Metab Dispos2018 Jun;46(6):888-896doi: 10.1124/dmd.118.080952. Epub 2018 Mar 30. PubMed PMID: 29602798; PubMed Central PMCID: PMC5938891.

Gaedigk A, Dinh JC, Jeong H, Prasad B, Leeder JS. Ten Years’ Experience with the CYP2D6 Activity Score: A Perspective on Future Investigations to Improve Clinical Predictions for Precision Therapeutics. J Pers Med2018 Apr 17;8(2)doi: 10.3390/jpm8020015. Review. PubMed PMID: 29673183; PubMed Central PMCID: PMC6023391.

Bhatt DK, Prasad B. Critical Issues and Optimized Practices in Quantification of Protein Abundance Level to Determine Interindividual Variability in DMET Proteins by LC-MS/MS Proteomics. Clin Pharmacol Ther2018 Apr;103(4):619-630doi: 10.1002/cpt.819. Epub 2017 Sep 25. Review. PubMed PMID: 28833066; PubMed Central PMCID: PMC5816727.

Wong T, Wang Z, Chapron BD, Suzuki M, Claw KG, Gao C, Foti RS, Prasad B, Chapron A, Calamia J, Chaudhry A, Schuetz EG, Horst RL, Mao Q, de Boer IH, Thornton TA, Thummel KE. Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in Humans. Drug Metab Dispos2018 Apr;46(4):367-379doi: 10.1124/dmd.117.078428. Epub 2018 Jan 17. PubMed PMID: 29343609; PubMed Central PMCID: PMC5829543.

Billington S, Ray AS, Salphati L, Xiao G, Chu X, Humphreys WG, Liao M, Lee CA, Mathias A, Hop CECA, Rowbottom C, Evers R, Lai Y, Kelly EJ, Prasad B, Unadkat JD. Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics. Drug Metab Dispos2018 Feb;46(2):189-196doi: 10.1124/dmd.117.077289. Epub 2017 Nov 14. PubMed PMID: 29138286; PubMed Central PMCID: PMC5776333.

Liao MZ, Gao C, Phillips BR, Neradugomma NK, Han LW, Bhatt DK, Prasad B, Shen DD, Mao Q. Pregnancy Increases Norbuprenorphine Clearance in Mice by Induction of Hepatic Glucuronidation. Drug Metab Dispos2018 Feb;46(2):100-108doi: 10.1124/dmd.117.076745. Epub 2017 Nov 20. PubMed PMID: 29158248; PubMed Central PMCID: PMC5765905.

Basit A, Zhang H, Bhatt DK, Amory JK, Prasad B. Effect of oral testosterone on the plasma steroid metabolomics in humans. Drug metabolism and pharmacokinetics. 2018; 33:S22eS97.

Vrana M, Xu M, Zhang H, Prasad B. A thorough characterization of subcellular localization and evaluation of the impact of processing variables on recovery and enrichment of drug metabolizing enzymes during subcellular fractionation. Drug Metabolism and Pharmacokinetics. 2018; 33:S20.

Anoshchenko O, Prasad B, Unadkat JD. Gestational age-dependent abundance of drug transporters and metabolizing enzymes in human placentae quantified by LC–MS/MS proteomics. Drug Metabolism and Pharmacokinetics. 2018; 33:S97.

Liao MZ, Gao C, Bhatt DK, Prasad B, Mao Q. Quantitative Proteomics Reveals Changes in Transporter Protein Abundance in Liver, Kidney and Brain of Mice by Pregnancy. Drug Metab Lett2018;12(2):145-152doi: 10.2174/1872312812666180625122810. PubMed PMID: 29938623; PubMed Central PMCID: PMC6350206.

Tanner JA, Zhu AZ, Claw KG, Prasad B, Korchina V, Hu J, Doddapaneni H, Muzny DM, Schuetz EG, Lerman C, Thummel KE, Scherer SE, Tyndale RF. Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism. Pharmacogenet Genomics2018 Jan;28(1):7-16doi: 10.1097/FPC.0000000000000317. PubMed PMID: 29232328; PubMed Central PMCID: PMC5729933.

Xu M, Vrana M, Zhang H, Prasad B. An LC-MS/MS proteomics based methodology to simultaneously evaluate the recovery, enrichment and purity of microsomal and cytosolic fractions isolated from tissues for in vitro drug metabolism studies. Drug Metabolism and Pharmacokinetics. 2018; 33:S17.