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Position:

Postdoctoral Research Associate

Education:

  • Ph.D. in Pharmaceutical Analysis – National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar, India
  • Master of Science in Pharmaceutical Analysis – National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar, India
  • Bachelor in Pharmaceutical Sciences – Maharshi Dayanand University, Rohtak, India

Research Interests:

  • Quantitative mass spectrometry (targeted and untargeted metabolomics)

About:

Dr. Dilip is a postdoctoral research associate in the Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences at Washington State University, Spokane. He has 5 years of pharmaceutical industry experience at the Biocon Bristol Myers Squibb Research & Development Center (BBRC), Bengaluru and Sandoz (a Novartis division), Hyderabad, India, supporting small molecule drug discovery and generic pharmaceuticals development. He specializes in mass spectrometry based structural characterization of small molecules (e.g., NCEs, impurities, degradation products, metabolites). Dr. Dilip is the recipient of 2018 Nico Nibbering Travel Award sponsored by International Mass Spectrometry Foundation (IMSF). He obtained his MS in 2012 and Ph.D. in 2020 in Pharmaceutical Sciences from NIPER, Mohali, India

Publications:

  1. Subash S., Singh D.K., Ahire D.S., Khojasteh S.C., Murray B.P., Zientek M, Jones R.S., Kulkarni P., Smith B.J., Heyward S., Cronin C.N., Prasad B., 2023. Dissecting parameters contributing to the underprediction of aldehyde oxidase-mediated metabolic clearance of drugs. Drug Metabolism and Disposition. DOI: https://doi.org/10.1124/dmd.123.001379
  2. Kruger L., Lapehn S., Paquette A., Singh D.K., MacDonald J., Bammler T.K., Enquobahrie D.A., Zhao Q., Mozhui K., Sathyanarayana S., and Prasad B., 2023. Characterization of xenobiotic and steroid disposition potential of human placental tissue and cell lines (BeWo, JEG-3, JAR, and HTR-8/SVneo) by quantitative proteomics. Drug Metabolism and Disposition, 51 (6), pp.1493-1500.
  3. Sharma S., Singh D.K., Mettu V.S., Yue G., Ahire D., Basit A., Heyward S., and Prasad B., 2023 Quantitative characterization of clinically relevant drug-metabolizing enzymes and transporters in rat liver and intestinal segments for applications in PBPK modeling. Molecular Pharmaceutics, 20(3), pp. 1737–1749
  4. Sharma, S., Ahire, D., Basit, A., Lajoie, M., Wang, C., Lee, M.S., Blithe, D.L., Amory, J.K., Singh, D.K., Heyward, S. and Prasad, B., 2022. Dimethandrolone, a potential male contraceptive pill, is primarily metabolized by the highly polymorphic UDP-glucuronosyltransferase 2B17 enzyme in human intestine and liver. Drug Metabolism and Disposition, 50(12), pp.1493-1500.

Posters:

  1. Singh D.K., Ahire D., and Prasad B., A PheWAS and genotype-informed metabolomics approach revealed potentially novel endogenous substrates of UGT2B17. 2023 Drug Metabolism GRC Meeting, Holderness, NH, United States (July 9 – 14, 2023).
  2. Singh D.K., Mettu V.S., Thakur A., Ailabouni A.S., Naji-Talakar S., and Prasad B., High-resolution mass spectrometry coupled with XCMS online for high-throughput detection and identification of drug metabolites. ASPET 2023 Annual Meeting, St Louis, MO, USA (May 18 – 21, 2023).
  3. Singh, D.K., Ahire, D., Yue, G., and Prasad, B., Global versus targeted proteomics for quantification of DMET proteins in human liver, kidney, and intestine. ISSX/MDO 2022 Meeting, Seattle, WA (September 9 – 14, 2022).

Contact Details:

Telephone: (509) 368-6535

Email: dilip.singh@wsu.edu

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Office Location: Pharmaceutical & Biomedical Sciences Building, Room # PBS-322, Spokane, WA