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Position:

PhD Candidate

Education

  • Master of Science in Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar, India
  • Bachelor of Pharmacy, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), University of Delhi, India
  • Diploma of Pharmacy, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), University of Delhi, India

Research Interests

  • Enzyme- and transporter-mediated drug disposition
  • In vitro–in vivo extrapolation (IVIVE)
  • PBPK modeling for prediction of pharmacokinetics in special populations

About

Aarzoo is a Ph.D. student in the College of Pharmacy and Pharmaceutical Sciences at the Washington State University (WSU), Spokane. She is a pharmacist by profession. During Masters, her project focused on prediction of oral drug absorption using different physiologically based pharmacokinetic (PBPK) modeling software. Thereafter, she worked as a Research Officer at Agency for Science, Technology and Research (A*STAR), Singapore for ~1.5 years. At A*STAR, she was involved in projects on mechanistic prediction of disposition of drugs and environmental toxicants using different in vitro and in silico tools.

Publications:

  1. Thakur A., Yue G., Ahire D., Mettu V.S., Maghribi A.A., Ford K., Peixoto L., Leeder J.S., & Prasad B. (2024) Sex and the Kidney Drug-Metabolizing Enzymes and Transporters: Are Preclinical Drug Disposition Data Translatable to Humans? Clinical Pharmacology & Therapeutics.
  2. Thakur A., Mettu V.S., Singh D.K., & Prasad B. (2023) Effect of probenecid on blood levels and renal elimination of furosemide and endogenous compounds in rats: Discovery of putative organic anion transporter biomarkers. Biochemical Pharmacology, 218: 115867.
  3. Ailabouni A., Mettu V.S., Thakur A., Singh D.K., & Prasad B. (2023) Effect of cimetidine on metformin pharmacokinetics and endogenous metabolite levels in rats. Drug Metabolism and Disposition, 52(2), 86-94.
  4. Thakur A., Tan, Z., Kameyama, T., El-Khateeb, E., Nagpal, S., Malone, S., Jamwal, R. & Nwabufo, C.K. (2021) Bioanalytical strategies in drug discovery and development. Drug metabolism reviews, 53(3): 434-458 (IF 4.5).
  5. Thakur A.#, Pervez M.#, Prasad B, Leeder S., Ontogeny of drug metabolizing enzymes. In: Nagar S., Argikar U., Tweedie D., (Eds.), Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications, (2nd ), 2021, 551-593.
    #Equal contribution
  6. Chapa R., Li C.Y., Basit A., Thakur A., Ladumor M.K., Sharma S., Singh S., Selen A. & Prasad B. (2020) Contribution of uptake and efflux transporters to oral pharmacokinetics of furosemide. ACS Omega, 5(51): 32939-32950 (IF 3.5).
  7. Thakur A.#, Tan S.P.F# & Chan J.C.Y. (2020) Physiologically-based pharmacokinetic modeling for predicting the clinical efficacy of the coadministration of lopinavir and ritonavir against SARS-CoV-2. Clinical Pharmacology & Therapeutics, 108(6):1176-1184 (IF 6.565). #Equal contribution
  8. Ladumor M.K., Thakur A., Sharma S., Rachapally A., Mishra S., Bobe P., Rao K., Pammi P., Kangne H., Levi D., Balhara A., Ghandikota S., Joshi A., Nautiyal V., Prasad B. & Singh S. (2019) An open access repository of protein abundance data of drug metabolizing enzymes and transporters for applications in physiologically based pharmacokinetics (PBPK) modelling and simulation. Scientific Reports-Nature, 9(1):9709 (IF 4.53).
  9. Ladumor M.K., Bhatt D.K., Gaedigk A., Sharma S., Thakur A., Pearce R.E., Leeder J.S., Bolger M.B., Singh S., & Prasad B. (2019) Ontogeny of hepatic sulfotransferases (SULTs) and prediction of age-dependent fractional contribution of sulfation in acetaminophen metabolism. Drug Metabolism and Disposition, 47(8): 818-831 (IF 3.35).

Posters:

  1. Thakur A, Singh D.K., Kis E., Gáborik Z., Paine M.F., & Prasad B. De Novo Identification and Validation of Human Endogenous Biomarkers of Renal Organic Anion Transporters for Predicting Interindividual Variability. Presented at ASPET Meeting 2024, Arlington, United States, 16th to 19th May 2024.
  2. Thakur A, Singh D.K., Paine M.F., & Prasad B. Novel metabolomics approach to identify biomarkers of organic anion renal transporters. Presented at ISSX Meeting 2023, Boston, United States, 10th to 13th September 2023.
  3. Thakur A, Yue G., Ahire D., Sharma S., Mettu V.S., Leeder J.S., & Prasad B. Sex and the kidneys with reference to the FDA Modernization Act 2.0: Are preclinical data of renally-cleared drugs translatable to humans? Presented at Drug Metabolism Gordon Research Conference 2023, Holderness, United States, 9th to 14th July 2023.
  4. Thakur A, Singh D.K., Paine M.F., & Prasad B. Identification of putative novel biomarkers of organic anion transporter 1 and 3 for the prediction of transporter-mediated drug-drug interactions. Presented at ASPET Annual Meeting 2023, St. Louis, United States, 18th to 21st May 2023.
  5. Thakur A., Mettu V, Nguyen J.Y., Paine M.F., & Prasad B. Rat as a model for predicting human renal organic anion transporter-mediated drug-drug interactions. Presented at International Society for the Study of Xenobiotics (ISSX) Meeting 2022, Seattle, United States, 11th to 14th September 2022.
  6. Thakur A. & Prasad B. Assessing the effect of organic anion transporter inhibition on circulating pyridoxic acid, an endogenous transporter biomarker, using physiologically-based pharmacokinetic modeling. Presented at ASPET Annual Meeting, EB 2022, Philadelphia, United States, 2nd to 5th April 2022.
  7. Thakur A., Ellison C. & Chan J.C.Y.* Physiologically-based pharmacokinetic modelling of 2,4-dichlorophenoxyacetic acid. Presented at 61st Annual Meeting, Society of Toxicology, San Diego, United States, 27th to 31st March 2022.
  8. Thakur A., Ladumor M.K., Sharma S., Prasad B. & Singh S. Predictive analysis of the intestinal bioavailability using in-house built mechanistic oral absorption model. Presented at 4th Annual Meeting, Indian Society for the Study of Xenobiotics (SSX-India), Bangalore, India, 19th to 21st September 2019.
  9. Thakur A., Ladumor M.K., Prasad B. & Singh S. Insight into the enzyme- and transporter-mediated disposition and DDI of probe substrate in healthy and diseased populations employing physiologically based pharmacokinetic analysis. Presented at 3rd Annual Meeting, SSX-India, Bangalore, India, 11th to 13th October 2018.

Contact:

Telephone: (509) 368-6535

Email: aarzoo.thakur@wsu.edu

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Office Location: Pharmaceutical & Biomedical Sciences Building,  Room# PBS-320, Spokane, WA